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Small differences in the effects of stearic acid, oleic acid, and linoleic acid on the serum lipoprotein profile of humans.
Am J Clin Nutr. 2005 Sep; 82(3):510-6.AJ

Abstract

BACKGROUND

Studies have suggested that oleic and stearic acids, as well as oleic and linoleic acids, have comparable effects on the serum lipoprotein profile. If so, then substituting these three 18-carbon fatty acids for each other would result in similar effects on the serum lipoprotein profile.

OBJECTIVE

The aim of this study was to compare simultaneously the effects of stearic, oleic, and linoleic acids on the serum lipoprotein profile of healthy subjects.

DESIGN

Forty-five subjects (27 women and 18 men) consumed in random order 3 experimental diets, each for 5 wk. The diets provided 38% of energy from fat, of which 60% was supplied by the experimental fats. The dietary compositions of the diets were the same, except for 7% of energy, which was provided by stearic, oleic, or linoleic acid. At the end of each intervention period, serum lipid and lipoprotein concentrations were measured. In addition, LDL, HDL, and VLDL particle sizes and particle concentrations of lipoprotein subclasses were analyzed by nuclear magnetic resonance spectroscopy.

RESULTS

No significant diet-induced changes in serum lipids and lipoproteins were found. Mean (+/-SD) serum LDL-cholesterol concentrations were 3.79 +/- 0.91, 3.71 +/- 0.79, and 3.65 +/- 0.91 mmol/L with the high-stearic acid, high-oleic acid, and high-linoleic acid diets, respectively (P = 0.137 for diet effects). Mean (+/-SD) HDL-cholesterol concentrations were 1.45 +/- 0.43, 1.46 +/- 0.45, and 1.46 +/- 0.44 mmol/L (P = 0.866). LDL, HDL, and VLDL particle sizes and lipoprotein subclass distributions also did not differ significantly between the 3 diets.

CONCLUSIONS

With realistic intakes of stearic, oleic, and linoleic acids, differences between their effects on the serum lipoprotein profile are small.

Authors+Show Affiliations

Department of Human Biology, Maastricht University, Maastricht, The Netherlands. m.thijssen@hb.unimaas.nlNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16155261

Citation

Thijssen, Myriam A., and Ronald P. Mensink. "Small Differences in the Effects of Stearic Acid, Oleic Acid, and Linoleic Acid On the Serum Lipoprotein Profile of Humans." The American Journal of Clinical Nutrition, vol. 82, no. 3, 2005, pp. 510-6.
Thijssen MA, Mensink RP. Small differences in the effects of stearic acid, oleic acid, and linoleic acid on the serum lipoprotein profile of humans. Am J Clin Nutr. 2005;82(3):510-6.
Thijssen, M. A., & Mensink, R. P. (2005). Small differences in the effects of stearic acid, oleic acid, and linoleic acid on the serum lipoprotein profile of humans. The American Journal of Clinical Nutrition, 82(3), 510-6.
Thijssen MA, Mensink RP. Small Differences in the Effects of Stearic Acid, Oleic Acid, and Linoleic Acid On the Serum Lipoprotein Profile of Humans. Am J Clin Nutr. 2005;82(3):510-6. PubMed PMID: 16155261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Small differences in the effects of stearic acid, oleic acid, and linoleic acid on the serum lipoprotein profile of humans. AU - Thijssen,Myriam A, AU - Mensink,Ronald P, PY - 2005/9/13/pubmed PY - 2005/11/3/medline PY - 2005/9/13/entrez SP - 510 EP - 6 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 82 IS - 3 N2 - BACKGROUND: Studies have suggested that oleic and stearic acids, as well as oleic and linoleic acids, have comparable effects on the serum lipoprotein profile. If so, then substituting these three 18-carbon fatty acids for each other would result in similar effects on the serum lipoprotein profile. OBJECTIVE: The aim of this study was to compare simultaneously the effects of stearic, oleic, and linoleic acids on the serum lipoprotein profile of healthy subjects. DESIGN: Forty-five subjects (27 women and 18 men) consumed in random order 3 experimental diets, each for 5 wk. The diets provided 38% of energy from fat, of which 60% was supplied by the experimental fats. The dietary compositions of the diets were the same, except for 7% of energy, which was provided by stearic, oleic, or linoleic acid. At the end of each intervention period, serum lipid and lipoprotein concentrations were measured. In addition, LDL, HDL, and VLDL particle sizes and particle concentrations of lipoprotein subclasses were analyzed by nuclear magnetic resonance spectroscopy. RESULTS: No significant diet-induced changes in serum lipids and lipoproteins were found. Mean (+/-SD) serum LDL-cholesterol concentrations were 3.79 +/- 0.91, 3.71 +/- 0.79, and 3.65 +/- 0.91 mmol/L with the high-stearic acid, high-oleic acid, and high-linoleic acid diets, respectively (P = 0.137 for diet effects). Mean (+/-SD) HDL-cholesterol concentrations were 1.45 +/- 0.43, 1.46 +/- 0.45, and 1.46 +/- 0.44 mmol/L (P = 0.866). LDL, HDL, and VLDL particle sizes and lipoprotein subclass distributions also did not differ significantly between the 3 diets. CONCLUSIONS: With realistic intakes of stearic, oleic, and linoleic acids, differences between their effects on the serum lipoprotein profile are small. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/16155261/Small_differences_in_the_effects_of_stearic_acid_oleic_acid_and_linoleic_acid_on_the_serum_lipoprotein_profile_of_humans_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn.82.3.510 DB - PRIME DP - Unbound Medicine ER -