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Comparison of isotope dilution with bioimpedance spectroscopy and anthropometry for assessment of body composition in asymptomatic HIV-infected and HIV-uninfected breastfeeding mothers.
Am J Clin Nutr. 2005 Sep; 82(3):538-46.AJ

Abstract

BACKGROUND

The effect of breastfeeding on the nutrition of HIV-infected (HIV+) mothers is unknown. Simple, valid methods are needed for body-composition assessment of HIV+ women.

OBJECTIVE

We compared the ability of bioimpedance spectroscopy (BIS) and anthropometry with that of isotope dilution (2H2O) to measure fat-free mass (FFM) and fat mass (FM) in HIV+ and HIV-uninfected (HIV-) breastfeeding South African mothers.

DESIGN

Total body water (TBW) content of 68 lactating mothers (20 HIV+, 48 HIV-) was measured 10 wk after delivery by using BIS and 2H2O to measure FFM and FM. Anthropometric measurements included body mass index (BMI; in kg/m2), midupper arm circumference (MUAC), and 4 skinfold thicknesses.

RESULTS

TBW, FFM, and FM measurements determined by BIS were correlated with 2H2O measurements in HIV+ (r = 0.664, 0.621, and 0.872, respectively; P < 0.01) and HIV- (r = 0.876, 0.868, and 0.932, respectively; P < 0.001) mothers. TBW measured by BIS was greater than that measured by the 2H2O method in both HIV+ (1.8 L) and HIV- (1.5 L) women; FM or FFM did not differ significantly by method. BMI, MUAC, and all skinfold-thickness measurements correlated strongly (r > 0.62, P < 0.001) with FM measured by 2H2O in both groups. BMI and MUAC correlated (r > 0.64, P < 0.001) with FFM in HIV- mothers but not in HIV+ mothers.

CONCLUSIONS

In HIV+ and HIV- breastfeeding mothers, BIS provides an estimate of body composition comparable to that obtained with the 2H2O method. BMI and MUAC are useful in predicting FM in both groups but are not valid measures of FFM in HIV+ mothers.

Authors+Show Affiliations

Africa Centre for Health and Population Studies, Somekele, South Africa. pcpapathakis@ucdavis.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Validation Study

Language

eng

PubMed ID

16155265

Citation

Papathakis, Peggy C., et al. "Comparison of Isotope Dilution With Bioimpedance Spectroscopy and Anthropometry for Assessment of Body Composition in Asymptomatic HIV-infected and HIV-uninfected Breastfeeding Mothers." The American Journal of Clinical Nutrition, vol. 82, no. 3, 2005, pp. 538-46.
Papathakis PC, Rollins NC, Brown KH, et al. Comparison of isotope dilution with bioimpedance spectroscopy and anthropometry for assessment of body composition in asymptomatic HIV-infected and HIV-uninfected breastfeeding mothers. Am J Clin Nutr. 2005;82(3):538-46.
Papathakis, P. C., Rollins, N. C., Brown, K. H., Bennish, M. L., & Van Loan, M. D. (2005). Comparison of isotope dilution with bioimpedance spectroscopy and anthropometry for assessment of body composition in asymptomatic HIV-infected and HIV-uninfected breastfeeding mothers. The American Journal of Clinical Nutrition, 82(3), 538-46.
Papathakis PC, et al. Comparison of Isotope Dilution With Bioimpedance Spectroscopy and Anthropometry for Assessment of Body Composition in Asymptomatic HIV-infected and HIV-uninfected Breastfeeding Mothers. Am J Clin Nutr. 2005;82(3):538-46. PubMed PMID: 16155265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of isotope dilution with bioimpedance spectroscopy and anthropometry for assessment of body composition in asymptomatic HIV-infected and HIV-uninfected breastfeeding mothers. AU - Papathakis,Peggy C, AU - Rollins,Nigel C, AU - Brown,Kenneth H, AU - Bennish,Michael L, AU - Van Loan,Marta D, PY - 2005/9/13/pubmed PY - 2005/11/3/medline PY - 2005/9/13/entrez SP - 538 EP - 46 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 82 IS - 3 N2 - BACKGROUND: The effect of breastfeeding on the nutrition of HIV-infected (HIV+) mothers is unknown. Simple, valid methods are needed for body-composition assessment of HIV+ women. OBJECTIVE: We compared the ability of bioimpedance spectroscopy (BIS) and anthropometry with that of isotope dilution (2H2O) to measure fat-free mass (FFM) and fat mass (FM) in HIV+ and HIV-uninfected (HIV-) breastfeeding South African mothers. DESIGN: Total body water (TBW) content of 68 lactating mothers (20 HIV+, 48 HIV-) was measured 10 wk after delivery by using BIS and 2H2O to measure FFM and FM. Anthropometric measurements included body mass index (BMI; in kg/m2), midupper arm circumference (MUAC), and 4 skinfold thicknesses. RESULTS: TBW, FFM, and FM measurements determined by BIS were correlated with 2H2O measurements in HIV+ (r = 0.664, 0.621, and 0.872, respectively; P < 0.01) and HIV- (r = 0.876, 0.868, and 0.932, respectively; P < 0.001) mothers. TBW measured by BIS was greater than that measured by the 2H2O method in both HIV+ (1.8 L) and HIV- (1.5 L) women; FM or FFM did not differ significantly by method. BMI, MUAC, and all skinfold-thickness measurements correlated strongly (r > 0.62, P < 0.001) with FM measured by 2H2O in both groups. BMI and MUAC correlated (r > 0.64, P < 0.001) with FFM in HIV- mothers but not in HIV+ mothers. CONCLUSIONS: In HIV+ and HIV- breastfeeding mothers, BIS provides an estimate of body composition comparable to that obtained with the 2H2O method. BMI and MUAC are useful in predicting FM in both groups but are not valid measures of FFM in HIV+ mothers. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/16155265/Comparison_of_isotope_dilution_with_bioimpedance_spectroscopy_and_anthropometry_for_assessment_of_body_composition_in_asymptomatic_HIV_infected_and_HIV_uninfected_breastfeeding_mothers_ DB - PRIME DP - Unbound Medicine ER -