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Long-term inhibition of angiotensin prevents reduction of periarterial innervation of calcitonin gene-related peptide (CGRP)-containing nerves in spontaneously hypertensive rats.
Hypertens Res. 2005 May; 28(5):465-74.HR

Abstract

The aim of this study was to investigate age-related changes in the density of calcitonin gene-related peptide (CGRP)-containing nerve fibers in spontaneously hypertensive rats (SHR) and the effects of long-term inhibition of the renin-angiotensin system on these changes. The density of immunocytochemically stained nerve fibers in the mesenteric artery was quantified by computer-assisted image processing. An age-related decrease in the density of CGRP-like immunoreactive (LI)-containing nerve fivers but not neuropeptide Y (NPY)-LI-containing sympathetic nerve fibers was found in the mesenteric artery of SHR but not Wistar Kyoto rats (WKY). The density of NPY-LI-containing sympathetic nerve fibers was significantly greater in SHR than in WKY. SHR were treated for 7 weeks with angiotensin converting enzyme inhibitor (0.005% temocapril), angiotensin II type-1 (AT1) receptor antagonist (0.025% losartan) or vasodilator (0.01% hydralazine) in their drinking water. Each drug treatment significantly lowered the systolic blood pressure measured by tail-cuff method. Long-term treatment of SHR with temocapril and losartan significantly increased the density of CGRP-LI-containing nerve fibers in mesenteric arteries. However, the density after hydralazine treatment was similar to the level in non-treated SHR. The density of NPY-LI-containing nerve fibers was not increased by any of the drug treatments. These results suggest that long-term inhibition of the renin-angiotensin system in SHR prevents remodeling of CGRPergic nerve fibers and prevents the reduction of CGRPergic nerve function.

Authors+Show Affiliations

Department of Clinical Pharmaceutical Science, Faculty of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16156511

Citation

Hobara, Narumi, et al. "Long-term Inhibition of Angiotensin Prevents Reduction of Periarterial Innervation of Calcitonin Gene-related Peptide (CGRP)-containing Nerves in Spontaneously Hypertensive Rats." Hypertension Research : Official Journal of the Japanese Society of Hypertension, vol. 28, no. 5, 2005, pp. 465-74.
Hobara N, Gessei-Tsutsumi N, Goda M, et al. Long-term inhibition of angiotensin prevents reduction of periarterial innervation of calcitonin gene-related peptide (CGRP)-containing nerves in spontaneously hypertensive rats. Hypertens Res. 2005;28(5):465-74.
Hobara, N., Gessei-Tsutsumi, N., Goda, M., Takayama, F., Akiyama, S., Kurosaki, Y., & Kawasaki, H. (2005). Long-term inhibition of angiotensin prevents reduction of periarterial innervation of calcitonin gene-related peptide (CGRP)-containing nerves in spontaneously hypertensive rats. Hypertension Research : Official Journal of the Japanese Society of Hypertension, 28(5), 465-74.
Hobara N, et al. Long-term Inhibition of Angiotensin Prevents Reduction of Periarterial Innervation of Calcitonin Gene-related Peptide (CGRP)-containing Nerves in Spontaneously Hypertensive Rats. Hypertens Res. 2005;28(5):465-74. PubMed PMID: 16156511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term inhibition of angiotensin prevents reduction of periarterial innervation of calcitonin gene-related peptide (CGRP)-containing nerves in spontaneously hypertensive rats. AU - Hobara,Narumi, AU - Gessei-Tsutsumi,Noriko, AU - Goda,Mitsuhiro, AU - Takayama,Fusako, AU - Akiyama,Shinji, AU - Kurosaki,Yuji, AU - Kawasaki,Hiromu, PY - 2005/9/15/pubmed PY - 2005/10/6/medline PY - 2005/9/15/entrez SP - 465 EP - 74 JF - Hypertension research : official journal of the Japanese Society of Hypertension JO - Hypertens Res VL - 28 IS - 5 N2 - The aim of this study was to investigate age-related changes in the density of calcitonin gene-related peptide (CGRP)-containing nerve fibers in spontaneously hypertensive rats (SHR) and the effects of long-term inhibition of the renin-angiotensin system on these changes. The density of immunocytochemically stained nerve fibers in the mesenteric artery was quantified by computer-assisted image processing. An age-related decrease in the density of CGRP-like immunoreactive (LI)-containing nerve fivers but not neuropeptide Y (NPY)-LI-containing sympathetic nerve fibers was found in the mesenteric artery of SHR but not Wistar Kyoto rats (WKY). The density of NPY-LI-containing sympathetic nerve fibers was significantly greater in SHR than in WKY. SHR were treated for 7 weeks with angiotensin converting enzyme inhibitor (0.005% temocapril), angiotensin II type-1 (AT1) receptor antagonist (0.025% losartan) or vasodilator (0.01% hydralazine) in their drinking water. Each drug treatment significantly lowered the systolic blood pressure measured by tail-cuff method. Long-term treatment of SHR with temocapril and losartan significantly increased the density of CGRP-LI-containing nerve fibers in mesenteric arteries. However, the density after hydralazine treatment was similar to the level in non-treated SHR. The density of NPY-LI-containing nerve fibers was not increased by any of the drug treatments. These results suggest that long-term inhibition of the renin-angiotensin system in SHR prevents remodeling of CGRPergic nerve fibers and prevents the reduction of CGRPergic nerve function. SN - 0916-9636 UR - https://www.unboundmedicine.com/medline/citation/16156511/Long_term_inhibition_of_angiotensin_prevents_reduction_of_periarterial_innervation_of_calcitonin_gene_related_peptide__CGRP__containing_nerves_in_spontaneously_hypertensive_rats_ DB - PRIME DP - Unbound Medicine ER -