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Cord blood adiponectin in large-for-gestational age newborns.
Am J Obstet Gynecol 2005; 193(3 Pt 2):1238-42AJ

Abstract

OBJECTIVE

The purpose of this study was to disclose the relationship between adiponectin and birth weight in a large group of newborns with normal and aberrant growth ("overweight").

STUDY DESIGN

Eighty-one healthy, term newborns were divided into 2 groups: 20 in the large-for-gestational age (LGA; 4297 +/- 207 g), and 61 newborns in the appropriate-for-gestational age (AGA; 3384 +/- 368 g). Cord blood was analyzed for adiponectin, leptin, and insulin levels.

RESULTS

Mean adiponectin level was significantly lower in LGA newborns (29.4 +/- 13.8 vs 35.0 +/- 9.9 microg/mL, P < .04). Both leptin and insulin levels were higher in LGA than AGA newborns, and leptin levels positively correlated with birth weight in both groups. Insulin levels positively correlated with birth weight in AGA newborns.

CONCLUSION

The results of this study imply that adiponectin may have a role in fetal growth and support the notion of negative feedback exerted by adipose tissue on adiponectin levels, as previously shown in adults.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, and Institute of Endocrinology, Sheba Medical Center, Tel-Hashomer, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16157144

Citation

Mazaki-Tovi, Shali, et al. "Cord Blood Adiponectin in Large-for-gestational Age Newborns." American Journal of Obstetrics and Gynecology, vol. 193, no. 3 Pt 2, 2005, pp. 1238-42.
Mazaki-Tovi S, Kanety H, Pariente C, et al. Cord blood adiponectin in large-for-gestational age newborns. Am J Obstet Gynecol. 2005;193(3 Pt 2):1238-42.
Mazaki-Tovi, S., Kanety, H., Pariente, C., Hemi, R., Schiff, E., & Sivan, E. (2005). Cord blood adiponectin in large-for-gestational age newborns. American Journal of Obstetrics and Gynecology, 193(3 Pt 2), pp. 1238-42.
Mazaki-Tovi S, et al. Cord Blood Adiponectin in Large-for-gestational Age Newborns. Am J Obstet Gynecol. 2005;193(3 Pt 2):1238-42. PubMed PMID: 16157144.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cord blood adiponectin in large-for-gestational age newborns. AU - Mazaki-Tovi,Shali, AU - Kanety,Hannah, AU - Pariente,Clara, AU - Hemi,Rina, AU - Schiff,Eyal, AU - Sivan,Eyal, PY - 2005/02/28/received PY - 2005/05/02/revised PY - 2005/05/11/accepted PY - 2005/9/15/pubmed PY - 2005/10/27/medline PY - 2005/9/15/entrez SP - 1238 EP - 42 JF - American journal of obstetrics and gynecology JO - Am. J. Obstet. Gynecol. VL - 193 IS - 3 Pt 2 N2 - OBJECTIVE: The purpose of this study was to disclose the relationship between adiponectin and birth weight in a large group of newborns with normal and aberrant growth ("overweight"). STUDY DESIGN: Eighty-one healthy, term newborns were divided into 2 groups: 20 in the large-for-gestational age (LGA; 4297 +/- 207 g), and 61 newborns in the appropriate-for-gestational age (AGA; 3384 +/- 368 g). Cord blood was analyzed for adiponectin, leptin, and insulin levels. RESULTS: Mean adiponectin level was significantly lower in LGA newborns (29.4 +/- 13.8 vs 35.0 +/- 9.9 microg/mL, P < .04). Both leptin and insulin levels were higher in LGA than AGA newborns, and leptin levels positively correlated with birth weight in both groups. Insulin levels positively correlated with birth weight in AGA newborns. CONCLUSION: The results of this study imply that adiponectin may have a role in fetal growth and support the notion of negative feedback exerted by adipose tissue on adiponectin levels, as previously shown in adults. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/16157144/Cord_blood_adiponectin_in_large_for_gestational_age_newborns_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9378(05)00727-1 DB - PRIME DP - Unbound Medicine ER -