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Plasma levels of lipophilic antioxidant vitamins in acute ischemic stroke patients: correlation to inflammation markers and neurological deficits.
Nutrition. 2005 Oct; 21(10):987-93.N

Abstract

OBJECTIVES

Acute ischemic stroke is a clinical condition accompanied by inflammation and oxidative stress. In this study, we compared levels of plasma lipophilic antioxidants and inflammation markers between patients with stroke and healthy controls and assessed the associations of antioxidants, inflammation markers, and neurologic deficits among patients with stroke.

METHODS

We measured plasma levels of lipophilic antioxidant vitamins (retinol, lycopene, alpha-carotene, beta-carotene, alpha-tocopherol, and gamma-tocopherol), inflammation markers (high-sensitivity C-reactive protein [hs-CRP], fibrinogen, erythrocyte sedimentation rate, and white blood cell count), and neurologic deficits (indicated by the score of the National Institute of Health Stroke Scale) in 68 patients with acute ischemic stroke within 48 h after stroke onset in comparison with 41 normal controls.

RESULTS

Plasma alpha- and beta-carotene concentrations were lower and levels of inflammation markers were higher among patients with acute ischemic stroke compared with normal controls. Levels of alpha- and beta-carotene in patients with stroke were negatively associated with hs-CRP level (R = -0.29 and -0.41, respectively, P < 0.01) and with neurologic deficits (R = -0.28 and -0.27, respectively, P < 0.05). The negative association between neurologic deficits and combined plasma levels of alpha- and beta-carotene remained after adjustment for age and sex (P = 0.04). However, the magnitude of association decreased after adjustment of hs-CRP (P = 0.08).

CONCLUSION

Plasma concentrations of alpha- and beta-carotene are lower in patients with acute ischemic stroke than in healthy controls and are negatively correlated with hs-CRP level and neurologic deficits. The negative association between neurologic deficits and combined plasma alpha- and beta-carotene levels is confounded by hs-CRP.

Authors+Show Affiliations

Department of Neurology, Chi-Mei Foundation Hospital, Tainan, Taiwan, ROC.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16157235

Citation

Chang, Chia-Yu, et al. "Plasma Levels of Lipophilic Antioxidant Vitamins in Acute Ischemic Stroke Patients: Correlation to Inflammation Markers and Neurological Deficits." Nutrition (Burbank, Los Angeles County, Calif.), vol. 21, no. 10, 2005, pp. 987-93.
Chang CY, Chen JY, Ke D, et al. Plasma levels of lipophilic antioxidant vitamins in acute ischemic stroke patients: correlation to inflammation markers and neurological deficits. Nutrition. 2005;21(10):987-93.
Chang, C. Y., Chen, J. Y., Ke, D., & Hu, M. L. (2005). Plasma levels of lipophilic antioxidant vitamins in acute ischemic stroke patients: correlation to inflammation markers and neurological deficits. Nutrition (Burbank, Los Angeles County, Calif.), 21(10), 987-93.
Chang CY, et al. Plasma Levels of Lipophilic Antioxidant Vitamins in Acute Ischemic Stroke Patients: Correlation to Inflammation Markers and Neurological Deficits. Nutrition. 2005;21(10):987-93. PubMed PMID: 16157235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma levels of lipophilic antioxidant vitamins in acute ischemic stroke patients: correlation to inflammation markers and neurological deficits. AU - Chang,Chia-Yu, AU - Chen,Jen-Yin, AU - Ke,Dershin, AU - Hu,Miao-Lin, PY - 2004/11/28/received PY - 2005/02/02/accepted PY - 2005/9/15/pubmed PY - 2006/1/13/medline PY - 2005/9/15/entrez SP - 987 EP - 93 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 21 IS - 10 N2 - OBJECTIVES: Acute ischemic stroke is a clinical condition accompanied by inflammation and oxidative stress. In this study, we compared levels of plasma lipophilic antioxidants and inflammation markers between patients with stroke and healthy controls and assessed the associations of antioxidants, inflammation markers, and neurologic deficits among patients with stroke. METHODS: We measured plasma levels of lipophilic antioxidant vitamins (retinol, lycopene, alpha-carotene, beta-carotene, alpha-tocopherol, and gamma-tocopherol), inflammation markers (high-sensitivity C-reactive protein [hs-CRP], fibrinogen, erythrocyte sedimentation rate, and white blood cell count), and neurologic deficits (indicated by the score of the National Institute of Health Stroke Scale) in 68 patients with acute ischemic stroke within 48 h after stroke onset in comparison with 41 normal controls. RESULTS: Plasma alpha- and beta-carotene concentrations were lower and levels of inflammation markers were higher among patients with acute ischemic stroke compared with normal controls. Levels of alpha- and beta-carotene in patients with stroke were negatively associated with hs-CRP level (R = -0.29 and -0.41, respectively, P < 0.01) and with neurologic deficits (R = -0.28 and -0.27, respectively, P < 0.05). The negative association between neurologic deficits and combined plasma levels of alpha- and beta-carotene remained after adjustment for age and sex (P = 0.04). However, the magnitude of association decreased after adjustment of hs-CRP (P = 0.08). CONCLUSION: Plasma concentrations of alpha- and beta-carotene are lower in patients with acute ischemic stroke than in healthy controls and are negatively correlated with hs-CRP level and neurologic deficits. The negative association between neurologic deficits and combined plasma alpha- and beta-carotene levels is confounded by hs-CRP. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/16157235/Plasma_levels_of_lipophilic_antioxidant_vitamins_in_acute_ischemic_stroke_patients:_correlation_to_inflammation_markers_and_neurological_deficits_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(05)00196-6 DB - PRIME DP - Unbound Medicine ER -