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Molecular substrates for retrieval and reconsolidation of cocaine-associated contextual memory.
Neuron. 2005 Sep 15; 47(6):873-84.N

Abstract

Relapse into drug taking among addicts often depends on learned associations between drug-paired cues and the rewarding effects of these drugs, such as cocaine (COC). Memory for drug-paired cues resists extinction and contributes to the high rate of relapse; however, the molecular mechanisms underlying these associations are not understood. We show that COC-conditioned place preference (CPP) activates ERK, CREB, Elk-1, and Fos in the nucleus accumbens core (AcbC) but not shell. Intra-AcbC infusions of U0126, an inhibitor of the ERK kinase MEK, prevent both the activation of ERK, CREB, Elk-1, and Fos and retrieval of COC-CPP. When tested again 24 hr or 14 days after intra-AcbC infusions of U0126 or another MEK inhibitor, PD98059, CPP retrieval and concomitant protein activation were significantly attenuated. Together, these findings indicate the necessity of the AcbC ERK signaling pathway for drug-paired contextual cue memories and suggest that these strong memories can become susceptible to disruption by therapeutic agents.

Authors+Show Affiliations

Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92627, USA.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16157281

Citation

Miller, Courtney A., and John F. Marshall. "Molecular Substrates for Retrieval and Reconsolidation of Cocaine-associated Contextual Memory." Neuron, vol. 47, no. 6, 2005, pp. 873-84.
Miller CA, Marshall JF. Molecular substrates for retrieval and reconsolidation of cocaine-associated contextual memory. Neuron. 2005;47(6):873-84.
Miller, C. A., & Marshall, J. F. (2005). Molecular substrates for retrieval and reconsolidation of cocaine-associated contextual memory. Neuron, 47(6), 873-84.
Miller CA, Marshall JF. Molecular Substrates for Retrieval and Reconsolidation of Cocaine-associated Contextual Memory. Neuron. 2005 Sep 15;47(6):873-84. PubMed PMID: 16157281.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular substrates for retrieval and reconsolidation of cocaine-associated contextual memory. AU - Miller,Courtney A, AU - Marshall,John F, PY - 2005/03/09/received PY - 2005/06/17/revised PY - 2005/08/04/accepted PY - 2005/9/15/pubmed PY - 2005/12/13/medline PY - 2005/9/15/entrez SP - 873 EP - 84 JF - Neuron JO - Neuron VL - 47 IS - 6 N2 - Relapse into drug taking among addicts often depends on learned associations between drug-paired cues and the rewarding effects of these drugs, such as cocaine (COC). Memory for drug-paired cues resists extinction and contributes to the high rate of relapse; however, the molecular mechanisms underlying these associations are not understood. We show that COC-conditioned place preference (CPP) activates ERK, CREB, Elk-1, and Fos in the nucleus accumbens core (AcbC) but not shell. Intra-AcbC infusions of U0126, an inhibitor of the ERK kinase MEK, prevent both the activation of ERK, CREB, Elk-1, and Fos and retrieval of COC-CPP. When tested again 24 hr or 14 days after intra-AcbC infusions of U0126 or another MEK inhibitor, PD98059, CPP retrieval and concomitant protein activation were significantly attenuated. Together, these findings indicate the necessity of the AcbC ERK signaling pathway for drug-paired contextual cue memories and suggest that these strong memories can become susceptible to disruption by therapeutic agents. SN - 0896-6273 UR - https://www.unboundmedicine.com/medline/citation/16157281/Molecular_substrates_for_retrieval_and_reconsolidation_of_cocaine_associated_contextual_memory_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0896-6273(05)00655-0 DB - PRIME DP - Unbound Medicine ER -