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Effect of PPAR-alpha and -gamma agonist on the expression of visfatin, adiponectin, and TNF-alpha in visceral fat of OLETF rats.
Biochem Biophys Res Commun. 2005 Oct 28; 336(3):747-53.BB

Abstract

A variety of adipocytokines and peptides secreted from adipocytes have been considered to play a crucial role in obesity, insulin resistance, and type 2 diabetes. Recently, visfatin, a new adipocytokine, known as a pre-B cell colony-enhancing factor, has been isolated from visceral fat deposits. It has been shown to activate insulin receptors in a manner different from insulin. To understand the role of adipocytokines in improving insulin sensitivity via activation of the nuclear receptor peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and -gamma (PPAR-gamma), we examined the expression of visfatin, adiponectin, and TNF-alpha in visceral fat depots of Otsuka Long-Evans Tokushima fatty (OLETF) rats from early to advanced diabetic stage (from 28 to 40 weeks of age). Serum glucose and insulin concentrations significantly (P<0.05) decreased in rosiglitazone or fenofibrate-treated OLETF rats compared to untreated OLETF rats. Rosiglitazone significantly increased serum adiponectin concentration from 20 to 40 weeks of age (P<0.05), whereas fenofibrate reduced TNF-alpha concentration. The expression of visfatin and adiponectin mRNA in visceral fat deposits was elevated by rosiglitazone or fenofibrate treatments when compared to untreated OLETF rats (P<0.05), whereas, TNF-alpha mRNA was down-regulated by these drugs (P<0.05). These results suggest that rosiglitazone and fenofibrate may prevent type 2 diabetes by regulating adipocytokines including visfatin, adiponectin, and TNF-alpha.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul 152-050, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16157299

Citation

Choi, K C., et al. "Effect of PPAR-alpha and -gamma Agonist On the Expression of Visfatin, Adiponectin, and TNF-alpha in Visceral Fat of OLETF Rats." Biochemical and Biophysical Research Communications, vol. 336, no. 3, 2005, pp. 747-53.
Choi KC, Ryu OH, Lee KW, et al. Effect of PPAR-alpha and -gamma agonist on the expression of visfatin, adiponectin, and TNF-alpha in visceral fat of OLETF rats. Biochem Biophys Res Commun. 2005;336(3):747-53.
Choi, K. C., Ryu, O. H., Lee, K. W., Kim, H. Y., Seo, J. A., Kim, S. G., Kim, N. H., Choi, D. S., Baik, S. H., & Choi, K. M. (2005). Effect of PPAR-alpha and -gamma agonist on the expression of visfatin, adiponectin, and TNF-alpha in visceral fat of OLETF rats. Biochemical and Biophysical Research Communications, 336(3), 747-53.
Choi KC, et al. Effect of PPAR-alpha and -gamma Agonist On the Expression of Visfatin, Adiponectin, and TNF-alpha in Visceral Fat of OLETF Rats. Biochem Biophys Res Commun. 2005 Oct 28;336(3):747-53. PubMed PMID: 16157299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of PPAR-alpha and -gamma agonist on the expression of visfatin, adiponectin, and TNF-alpha in visceral fat of OLETF rats. AU - Choi,K C, AU - Ryu,O H, AU - Lee,K W, AU - Kim,H Y, AU - Seo,J A, AU - Kim,S G, AU - Kim,N H, AU - Choi,D S, AU - Baik,S H, AU - Choi,K M, PY - 2005/08/12/received PY - 2005/08/26/accepted PY - 2005/9/15/pubmed PY - 2005/11/3/medline PY - 2005/9/15/entrez SP - 747 EP - 53 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 336 IS - 3 N2 - A variety of adipocytokines and peptides secreted from adipocytes have been considered to play a crucial role in obesity, insulin resistance, and type 2 diabetes. Recently, visfatin, a new adipocytokine, known as a pre-B cell colony-enhancing factor, has been isolated from visceral fat deposits. It has been shown to activate insulin receptors in a manner different from insulin. To understand the role of adipocytokines in improving insulin sensitivity via activation of the nuclear receptor peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and -gamma (PPAR-gamma), we examined the expression of visfatin, adiponectin, and TNF-alpha in visceral fat depots of Otsuka Long-Evans Tokushima fatty (OLETF) rats from early to advanced diabetic stage (from 28 to 40 weeks of age). Serum glucose and insulin concentrations significantly (P<0.05) decreased in rosiglitazone or fenofibrate-treated OLETF rats compared to untreated OLETF rats. Rosiglitazone significantly increased serum adiponectin concentration from 20 to 40 weeks of age (P<0.05), whereas fenofibrate reduced TNF-alpha concentration. The expression of visfatin and adiponectin mRNA in visceral fat deposits was elevated by rosiglitazone or fenofibrate treatments when compared to untreated OLETF rats (P<0.05), whereas, TNF-alpha mRNA was down-regulated by these drugs (P<0.05). These results suggest that rosiglitazone and fenofibrate may prevent type 2 diabetes by regulating adipocytokines including visfatin, adiponectin, and TNF-alpha. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/16157299/Effect_of_PPAR_alpha_and__gamma_agonist_on_the_expression_of_visfatin_adiponectin_and_TNF_alpha_in_visceral_fat_of_OLETF_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(05)01932-7 DB - PRIME DP - Unbound Medicine ER -