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Alcohol consumption and risk of atrial fibrillation in men and women: the Copenhagen City Heart Study.
Circulation. 2005 Sep 20; 112(12):1736-42.Circ

Abstract

BACKGROUND

The relationship of the full range of alcohol consumption with risk of incident atrial fibrillation has been inconsistent in previous, mainly case-control studies.

METHODS AND RESULTS

In a prospective cohort study, we studied the association between self-reported alcohol use and incident atrial fibrillation among 16,415 women and men enrolled in the Copenhagen City Heart Study. We ascertained use of beer, wine, and spirits individually at up to 3 study visits with a structured questionnaire. We identified cases of atrial fibrillation by routine study ECGs and a validated nationwide registry of all hospitalizations. A total of 1071 cases occurred during follow-up. Among both women and men, alcohol consumption throughout the moderate range was not associated with risk of atrial fibrillation. However, consumption of 35 or more drinks per week among men was associated with a hazard ratio of 1.45 (95% CI 1.02 to 2.04); few women consumed this amount of alcohol. Approximately 5% of cases of atrial fibrillation among men were attributable to heavy alcohol use. Further adjustment for blood pressure and incident coronary heart disease and congestive heart failure did not attenuate the association (hazard ratio 1.63; 95% CI 1.15 to 2.31).

CONCLUSIONS

Heavy alcohol consumption is associated with a higher risk of atrial fibrillation, at least among men. This relationship does not appear to be related to the adverse effects of heavy drinking on coronary heart disease or blood pressure.

Authors+Show Affiliations

Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. kmukamal@bidmc.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16157768

Citation

Mukamal, Kenneth J., et al. "Alcohol Consumption and Risk of Atrial Fibrillation in Men and Women: the Copenhagen City Heart Study." Circulation, vol. 112, no. 12, 2005, pp. 1736-42.
Mukamal KJ, Tolstrup JS, Friberg J, et al. Alcohol consumption and risk of atrial fibrillation in men and women: the Copenhagen City Heart Study. Circulation. 2005;112(12):1736-42.
Mukamal, K. J., Tolstrup, J. S., Friberg, J., Jensen, G., & Grønbaek, M. (2005). Alcohol consumption and risk of atrial fibrillation in men and women: the Copenhagen City Heart Study. Circulation, 112(12), 1736-42.
Mukamal KJ, et al. Alcohol Consumption and Risk of Atrial Fibrillation in Men and Women: the Copenhagen City Heart Study. Circulation. 2005 Sep 20;112(12):1736-42. PubMed PMID: 16157768.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and risk of atrial fibrillation in men and women: the Copenhagen City Heart Study. AU - Mukamal,Kenneth J, AU - Tolstrup,Janne S, AU - Friberg,Jens, AU - Jensen,Gorm, AU - Grønbaek,Morten, Y1 - 2005/09/12/ PY - 2005/9/15/pubmed PY - 2006/3/10/medline PY - 2005/9/15/entrez SP - 1736 EP - 42 JF - Circulation JO - Circulation VL - 112 IS - 12 N2 - BACKGROUND: The relationship of the full range of alcohol consumption with risk of incident atrial fibrillation has been inconsistent in previous, mainly case-control studies. METHODS AND RESULTS: In a prospective cohort study, we studied the association between self-reported alcohol use and incident atrial fibrillation among 16,415 women and men enrolled in the Copenhagen City Heart Study. We ascertained use of beer, wine, and spirits individually at up to 3 study visits with a structured questionnaire. We identified cases of atrial fibrillation by routine study ECGs and a validated nationwide registry of all hospitalizations. A total of 1071 cases occurred during follow-up. Among both women and men, alcohol consumption throughout the moderate range was not associated with risk of atrial fibrillation. However, consumption of 35 or more drinks per week among men was associated with a hazard ratio of 1.45 (95% CI 1.02 to 2.04); few women consumed this amount of alcohol. Approximately 5% of cases of atrial fibrillation among men were attributable to heavy alcohol use. Further adjustment for blood pressure and incident coronary heart disease and congestive heart failure did not attenuate the association (hazard ratio 1.63; 95% CI 1.15 to 2.31). CONCLUSIONS: Heavy alcohol consumption is associated with a higher risk of atrial fibrillation, at least among men. This relationship does not appear to be related to the adverse effects of heavy drinking on coronary heart disease or blood pressure. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/16157768/Alcohol_consumption_and_risk_of_atrial_fibrillation_in_men_and_women:_the_Copenhagen_City_Heart_Study_ L2 - https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.105.547844?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -