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Polymorphisms of 5,10-methylenetetrahydrofolate reductase and risk of stomach cancer in a Korean population.
Anticancer Res. 2005 May-Jun; 25(3B):2249-52.AR

Abstract

BACKGROUND

Methylentetrahydrofolate reductase plays a central role in converting folate to methyl donor for DNA methylation. Genetic variations in folate metabolism are believed to contribute to the risk of acute lymphoblastic leukemia, colon, esophageal and stomach cancer, as well as cardiovascular and cerebrovascular diseases. MTHFR C677T and A1298C polymorphisms are known to be risk factors for gastric cancer in the Chinese population. Therefore, we hypothesized that the MTHFR polymorphisms are associated with the risk of stomach cancer in Korean subjects.

PATIENTS AND METHODS

We conducted a Korean population-based case-control study to examine the relationship between genetic polymorphisms in MTHFR and risk of stomach cancer. The study subjects were 133 patients with stomach cancer and 445 population controls, matched according to sex and age. Genomic DNA was extracted from blood samples of the controls and from surgically resected "normal" tissues adjacent to the tumor of stomach cancer patients. MTHFR genotypes at the C677T and A1298C sites were analyzed by PCR-based RFLP methods.

RESULTS

We found no evidence for an association between the MTHFR C677T and A1298C polymorphisms and stomach cancer in any of the subjects. The adjusted odds ratios and 95% confidence intervals for MTHFR C677T were 0.924 (0.581-1.469) for 677CT versus 677CC wild-type and 1.147 (0.850-1.549) for 677TT versus 677CC, and for MTHFR A1298C, they were 1.114 (0.695-1.783) for 1298AC versus 1298AA wild-type and 0.834 (0.284-2.450) for 1298CC versus 1298AA.

CONCLUSION

These results suggest that the MTHFR C677T and A1298C polymorphisms by themselves do not play an important role in the etiology of stomach cancer in the Korean population.

Authors+Show Affiliations

Institute for Clinical Research, 2Graduate School of Life Science and Biotechnology, College of Medicine, Pochon CHA University, Seongnam 463-712, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16158971

Citation

Kim, Jin Kyeoung, et al. "Polymorphisms of 5,10-methylenetetrahydrofolate Reductase and Risk of Stomach Cancer in a Korean Population." Anticancer Research, vol. 25, no. 3B, 2005, pp. 2249-52.
Kim JK, Kim S, Han JH, et al. Polymorphisms of 5,10-methylenetetrahydrofolate reductase and risk of stomach cancer in a Korean population. Anticancer Res. 2005;25(3B):2249-52.
Kim, J. K., Kim, S., Han, J. H., Kim, H. J., Chong, S. Y., Hong, S. P., Hwang, S. G., Ahn, J. Y., Cha, K. Y., Oh, D., & Kim, N. K. (2005). Polymorphisms of 5,10-methylenetetrahydrofolate reductase and risk of stomach cancer in a Korean population. Anticancer Research, 25(3B), 2249-52.
Kim JK, et al. Polymorphisms of 5,10-methylenetetrahydrofolate Reductase and Risk of Stomach Cancer in a Korean Population. Anticancer Res. 2005 May-Jun;25(3B):2249-52. PubMed PMID: 16158971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymorphisms of 5,10-methylenetetrahydrofolate reductase and risk of stomach cancer in a Korean population. AU - Kim,Jin Kyeoung, AU - Kim,Sehyun, AU - Han,Jin Hee, AU - Kim,Hyo Jin, AU - Chong,So Young, AU - Hong,Seong Pyo, AU - Hwang,Seong Gyu, AU - Ahn,Jung Yong, AU - Cha,Kwang Yul, AU - Oh,Doyeun, AU - Kim,Nam Keun, PY - 2005/9/15/pubmed PY - 2005/11/3/medline PY - 2005/9/15/entrez SP - 2249 EP - 52 JF - Anticancer research JO - Anticancer Res. VL - 25 IS - 3B N2 - BACKGROUND: Methylentetrahydrofolate reductase plays a central role in converting folate to methyl donor for DNA methylation. Genetic variations in folate metabolism are believed to contribute to the risk of acute lymphoblastic leukemia, colon, esophageal and stomach cancer, as well as cardiovascular and cerebrovascular diseases. MTHFR C677T and A1298C polymorphisms are known to be risk factors for gastric cancer in the Chinese population. Therefore, we hypothesized that the MTHFR polymorphisms are associated with the risk of stomach cancer in Korean subjects. PATIENTS AND METHODS: We conducted a Korean population-based case-control study to examine the relationship between genetic polymorphisms in MTHFR and risk of stomach cancer. The study subjects were 133 patients with stomach cancer and 445 population controls, matched according to sex and age. Genomic DNA was extracted from blood samples of the controls and from surgically resected "normal" tissues adjacent to the tumor of stomach cancer patients. MTHFR genotypes at the C677T and A1298C sites were analyzed by PCR-based RFLP methods. RESULTS: We found no evidence for an association between the MTHFR C677T and A1298C polymorphisms and stomach cancer in any of the subjects. The adjusted odds ratios and 95% confidence intervals for MTHFR C677T were 0.924 (0.581-1.469) for 677CT versus 677CC wild-type and 1.147 (0.850-1.549) for 677TT versus 677CC, and for MTHFR A1298C, they were 1.114 (0.695-1.783) for 1298AC versus 1298AA wild-type and 0.834 (0.284-2.450) for 1298CC versus 1298AA. CONCLUSION: These results suggest that the MTHFR C677T and A1298C polymorphisms by themselves do not play an important role in the etiology of stomach cancer in the Korean population. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/16158971/Polymorphisms_of_510_methylenetetrahydrofolate_reductase_and_risk_of_stomach_cancer_in_a_Korean_population_ L2 - http://ar.iiarjournals.org/cgi/pmidlookup?view=long&pmid=16158971 DB - PRIME DP - Unbound Medicine ER -