Tags

Type your tag names separated by a space and hit enter

Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes.
J Neuroendocrinol. 2005 Oct; 17(10):619-38.JN

Abstract

Gonadotrophin-releasing hormone (GnRH), acting via its cognate GnRH receptor (GnRHR), is the primary regulator of mammalian reproductive function, and hence GnRH analogues are extensively used in the treatment of hormone-dependent diseases, as well as for assisted reproductive techniques. In addition to its established endocrine role in gonadotrophin regulation in the pituitary, evidence is rapidly accumulating to support the expression and functional roles for two forms of GnRHR (GnRHR I and GnRHR II) in multiple and diverse extra-pituitary mammalian tissues and cells. These findings, together with findings indicating that mutations of the GnRHR are linked to the disease hypogonadotrophic hypogonadism and that GnRHRs play a direct role in neuronal migration and reproductive cancers, have presented new therapeutic targets and intensified research into the structure, function and mechanisms of regulation of expression of GnRHR genes. The present review focuses on the current knowledge on tissue-specific and hormonal regulation of transcription of mammalian GnRH receptor genes. Emerging insights, such as the discovery of diverse regulatory mechanisms in pituitary and extra-pituitary cell types, nonclassical mechanisms of steroid regulation, the use of composite elements for cell-specific expression, the increasing profile of hormones involved in regulation, the complexity of kinase pathways that target the GnRHR I gene, as well as species-differences, are highlighted. Although further research is necessary to understand the mechanisms of regulation of expression of GnRHR I and GnRHR II genes, the GnRHR is emerging as a potential target gene for facilitating cross-talk between neuroendocrine, immune and stress-response systems in multiple tissues via autocrine, paracrine and endocrine signalling.

Authors+Show Affiliations

Department of Biochemistry, University of Stellenbosch, Matieland, South Africa. jhap@sun.ac.zaNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16159375

Citation

Hapgood, J P., et al. "Regulation of Expression of Mammalian Gonadotrophin-releasing Hormone Receptor Genes." Journal of Neuroendocrinology, vol. 17, no. 10, 2005, pp. 619-38.
Hapgood JP, Sadie H, van Biljon W, et al. Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes. J Neuroendocrinol. 2005;17(10):619-38.
Hapgood, J. P., Sadie, H., van Biljon, W., & Ronacher, K. (2005). Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes. Journal of Neuroendocrinology, 17(10), 619-38.
Hapgood JP, et al. Regulation of Expression of Mammalian Gonadotrophin-releasing Hormone Receptor Genes. J Neuroendocrinol. 2005;17(10):619-38. PubMed PMID: 16159375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes. AU - Hapgood,J P, AU - Sadie,H, AU - van Biljon,W, AU - Ronacher,K, PY - 2005/9/15/pubmed PY - 2006/2/4/medline PY - 2005/9/15/entrez SP - 619 EP - 38 JF - Journal of neuroendocrinology JO - J Neuroendocrinol VL - 17 IS - 10 N2 - Gonadotrophin-releasing hormone (GnRH), acting via its cognate GnRH receptor (GnRHR), is the primary regulator of mammalian reproductive function, and hence GnRH analogues are extensively used in the treatment of hormone-dependent diseases, as well as for assisted reproductive techniques. In addition to its established endocrine role in gonadotrophin regulation in the pituitary, evidence is rapidly accumulating to support the expression and functional roles for two forms of GnRHR (GnRHR I and GnRHR II) in multiple and diverse extra-pituitary mammalian tissues and cells. These findings, together with findings indicating that mutations of the GnRHR are linked to the disease hypogonadotrophic hypogonadism and that GnRHRs play a direct role in neuronal migration and reproductive cancers, have presented new therapeutic targets and intensified research into the structure, function and mechanisms of regulation of expression of GnRHR genes. The present review focuses on the current knowledge on tissue-specific and hormonal regulation of transcription of mammalian GnRH receptor genes. Emerging insights, such as the discovery of diverse regulatory mechanisms in pituitary and extra-pituitary cell types, nonclassical mechanisms of steroid regulation, the use of composite elements for cell-specific expression, the increasing profile of hormones involved in regulation, the complexity of kinase pathways that target the GnRHR I gene, as well as species-differences, are highlighted. Although further research is necessary to understand the mechanisms of regulation of expression of GnRHR I and GnRHR II genes, the GnRHR is emerging as a potential target gene for facilitating cross-talk between neuroendocrine, immune and stress-response systems in multiple tissues via autocrine, paracrine and endocrine signalling. SN - 0953-8194 UR - https://www.unboundmedicine.com/medline/citation/16159375/Regulation_of_expression_of_mammalian_gonadotrophin_releasing_hormone_receptor_genes_ L2 - https://doi.org/10.1111/j.1365-2826.2005.01353.x DB - PRIME DP - Unbound Medicine ER -