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Breast-feeding reduces the risk for childhood eczema.
J Allergy Clin Immunol. 2005 Sep; 116(3):657-61.JA

Abstract

BACKGROUND

The evidence for a preventive effect of breast-feeding on the development of eczema in childhood remains controversial.

OBJECTIVE

To investigate the effect of breast-feeding in various phenotypes of eczema to 4 years.

METHODS

A birth cohort of 4089 children made up the study base. Data on breast-feeding, allergic symptoms, and potential confounders were obtained from questionnaires when the children were 2 months and 1, 2, and 4 years old. At 4 years, blood specific IgE was analyzed. Children with symptoms of eczema and asthma during the period of breast-feeding were excluded in most analyses on risk assessment of eczema and asthma, respectively, to avoid disease-related modification of exposure.

RESULTS

Exclusive breast-feeding for >or=4 months reduced the risk for eczema at the age of 4 years (odds ratio [OR], 0.78; 95% CI, 0.63--0.96) irrespective of combination with asthma, sensitization to common allergens, or parental allergic disease. This decreased risk was most evident for children with onset of eczema during the first 2 years persisting to 4 years (OR, 0.59; 95% CI, 0.45--0.77). Among children with early-onset eczema, irrespective of persistency, followed by late onset of asthma or early-onset asthma irrespective of persistency, followed by late-onset eczema to 4 years, a protective effect of breast-feeding was also seen (OR, 0.48; 95% CI, 0.30--0.76).

CONCLUSION

Breast-feeding 4 months or more reduces the risk for eczema and onset of the allergy march to age 4.

Authors+Show Affiliations

Department of Occupational and Environmental Health, Stockholm County Council, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. inger.kull@sll.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16159639

Citation

Kull, Inger, et al. "Breast-feeding Reduces the Risk for Childhood Eczema." The Journal of Allergy and Clinical Immunology, vol. 116, no. 3, 2005, pp. 657-61.
Kull I, Böhme M, Wahlgren CF, et al. Breast-feeding reduces the risk for childhood eczema. J Allergy Clin Immunol. 2005;116(3):657-61.
Kull, I., Böhme, M., Wahlgren, C. F., Nordvall, L., Pershagen, G., & Wickman, M. (2005). Breast-feeding reduces the risk for childhood eczema. The Journal of Allergy and Clinical Immunology, 116(3), 657-61.
Kull I, et al. Breast-feeding Reduces the Risk for Childhood Eczema. J Allergy Clin Immunol. 2005;116(3):657-61. PubMed PMID: 16159639.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast-feeding reduces the risk for childhood eczema. AU - Kull,Inger, AU - Böhme,Maria, AU - Wahlgren,Carl-Fredrik, AU - Nordvall,Lennart, AU - Pershagen,Göran, AU - Wickman,Magnus, PY - 2005/03/14/received PY - 2005/04/11/revised PY - 2005/04/14/accepted PY - 2005/9/15/pubmed PY - 2005/11/16/medline PY - 2005/9/15/entrez SP - 657 EP - 61 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 116 IS - 3 N2 - BACKGROUND: The evidence for a preventive effect of breast-feeding on the development of eczema in childhood remains controversial. OBJECTIVE: To investigate the effect of breast-feeding in various phenotypes of eczema to 4 years. METHODS: A birth cohort of 4089 children made up the study base. Data on breast-feeding, allergic symptoms, and potential confounders were obtained from questionnaires when the children were 2 months and 1, 2, and 4 years old. At 4 years, blood specific IgE was analyzed. Children with symptoms of eczema and asthma during the period of breast-feeding were excluded in most analyses on risk assessment of eczema and asthma, respectively, to avoid disease-related modification of exposure. RESULTS: Exclusive breast-feeding for >or=4 months reduced the risk for eczema at the age of 4 years (odds ratio [OR], 0.78; 95% CI, 0.63--0.96) irrespective of combination with asthma, sensitization to common allergens, or parental allergic disease. This decreased risk was most evident for children with onset of eczema during the first 2 years persisting to 4 years (OR, 0.59; 95% CI, 0.45--0.77). Among children with early-onset eczema, irrespective of persistency, followed by late onset of asthma or early-onset asthma irrespective of persistency, followed by late-onset eczema to 4 years, a protective effect of breast-feeding was also seen (OR, 0.48; 95% CI, 0.30--0.76). CONCLUSION: Breast-feeding 4 months or more reduces the risk for eczema and onset of the allergy march to age 4. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/16159639/Breast_feeding_reduces_the_risk_for_childhood_eczema_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(05)00771-2 DB - PRIME DP - Unbound Medicine ER -