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Antimicrobial activity of antibiotics in combination with natural flavonoids against clinical extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae.
Phytother Res. 2005 Jul; 19(7):612-7.PR

Abstract

Extended-spectrum beta-lactamases (ESBLs) are plasmid-mediated class A enzymes commonly found in the family Enterobacteriaceae, mainly in Klebsiella pneumoniae. Flavonoids have also been reported to possess antimicrobial activity. In this study, the in vitro activities of 18 antibiotics and 12 flavonoids against 20 ESBL-producing K. pneumoniae isolates were evaluated. All of these isolates were susceptible to imipenem and cefmetazole, but were resistant to ampicillin, ampicillin/sulbactam, aztreonam, cefazolin, cefoperazone, cefotaxime, ceftazidime, ceftriaxone, cefuroxime, piperacillin and ticarcillin. Susceptibilities to amikacin, amoxicillin/clavulanate, cefoxitin, ciprofloxacin and gentamicin were variable. Myricetin, a flavonol, inhibited ESBL-producing K. pneumoniae isolates at a high minimum inhibitory concentration (MIC) (MIC(90) value 256 mg/mL), but exhibited significant synergic activity against ESBL-producing K. pneumoniae in separate combination with amoxicillin/clavulanate, ampicillin/sulbactam and cefoxitin. Because of the low-toxic nature of flavonoids, the combination of antibiotics and flavonoids is a potential new strategy for developing therapies for infections caused by ESBL-producing bacteria in the future.

Authors+Show Affiliations

Department of Internal Medicine, Ho-Ping Branch, Taipei City Hospital, Taipei 100, Taiwan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16161024

Citation

Lin, Rong-Dih, et al. "Antimicrobial Activity of Antibiotics in Combination With Natural Flavonoids Against Clinical Extended-spectrum Beta-lactamase (ESBL)-producing Klebsiella Pneumoniae." Phytotherapy Research : PTR, vol. 19, no. 7, 2005, pp. 612-7.
Lin RD, Chin YP, Lee MH. Antimicrobial activity of antibiotics in combination with natural flavonoids against clinical extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae. Phytother Res. 2005;19(7):612-7.
Lin, R. D., Chin, Y. P., & Lee, M. H. (2005). Antimicrobial activity of antibiotics in combination with natural flavonoids against clinical extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae. Phytotherapy Research : PTR, 19(7), 612-7.
Lin RD, Chin YP, Lee MH. Antimicrobial Activity of Antibiotics in Combination With Natural Flavonoids Against Clinical Extended-spectrum Beta-lactamase (ESBL)-producing Klebsiella Pneumoniae. Phytother Res. 2005;19(7):612-7. PubMed PMID: 16161024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial activity of antibiotics in combination with natural flavonoids against clinical extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae. AU - Lin,Rong-Dih, AU - Chin,Yi-Ping, AU - Lee,Mei-Hsien, PY - 2005/9/15/pubmed PY - 2005/12/13/medline PY - 2005/9/15/entrez SP - 612 EP - 7 JF - Phytotherapy research : PTR JO - Phytother Res VL - 19 IS - 7 N2 - Extended-spectrum beta-lactamases (ESBLs) are plasmid-mediated class A enzymes commonly found in the family Enterobacteriaceae, mainly in Klebsiella pneumoniae. Flavonoids have also been reported to possess antimicrobial activity. In this study, the in vitro activities of 18 antibiotics and 12 flavonoids against 20 ESBL-producing K. pneumoniae isolates were evaluated. All of these isolates were susceptible to imipenem and cefmetazole, but were resistant to ampicillin, ampicillin/sulbactam, aztreonam, cefazolin, cefoperazone, cefotaxime, ceftazidime, ceftriaxone, cefuroxime, piperacillin and ticarcillin. Susceptibilities to amikacin, amoxicillin/clavulanate, cefoxitin, ciprofloxacin and gentamicin were variable. Myricetin, a flavonol, inhibited ESBL-producing K. pneumoniae isolates at a high minimum inhibitory concentration (MIC) (MIC(90) value 256 mg/mL), but exhibited significant synergic activity against ESBL-producing K. pneumoniae in separate combination with amoxicillin/clavulanate, ampicillin/sulbactam and cefoxitin. Because of the low-toxic nature of flavonoids, the combination of antibiotics and flavonoids is a potential new strategy for developing therapies for infections caused by ESBL-producing bacteria in the future. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/16161024/Antimicrobial_activity_of_antibiotics_in_combination_with_natural_flavonoids_against_clinical_extended_spectrum_beta_lactamase__ESBL__producing_Klebsiella_pneumoniae_ L2 - https://doi.org/10.1002/ptr.1695 DB - PRIME DP - Unbound Medicine ER -