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Effect of beta-blockers on cardiac function and calcium handling protein in postinfarction heart failure rats.
Chest. 2005 Sep; 128(3):1812-21.Chest

Abstract

OBJECTIVES

The normal expression of Ca2+-handling protein is critical for efficient myocardial function. The present study was designed to test the hypothesis that beta-blocker treatment may attenuate left ventricular (LV) remodeling and cardiac contractile dysfunction in the failing heart, which may be associated with alterations of Ca2+-handling protein

METHODS

We investigated the change of LV remodeling and function in a rat model of heart failure due to myocardial infarction (MI) with or without carvedilol (30 mg/kg/d) or metoprolol (60 mg/kg/d) treatment for 6 weeks (n = 9 in the MI plus carvedilol group, and n = 8 in every other group). The expression of messenger RNA and proteins of sarcoplasmic reticulum Ca2+-adenosine triphosphatase (SERCA) and phospholamban in cardiomyocytes of all rats were also measured

RESULTS

There was significant LV remodeling and cardiac contractile dysfunction in MI rats. The messenger RNA and protein expression of SERCA were down-regulated (p < 0.01), but the expression of phospholamban messenger RNA and protein were up-regulated (p < 0.01) in MI rats compared to sham-operated rats. After the treatment with beta-blockers, LV remodeling and function were clearly improved. Carvedilol was better in attenuating the weight of the LV and the relative weight of the right ventricle than metoprolol (p < 0.05). beta-Blockers restored the low expression of SERCA (p < 0.05) but showed no effect on phospholamban expression (p > 0.05). Moreover, carvedilol induced a more significant improvement of SERCA expression than metoprolol (p < 0.05)

CONCLUSIONS

Beta-blockers are effective in preventing LV remodeling and cardiac contractile dysfunction in the failing heart. The molecular mechanism may be related to normalization of SERCA expression.

Authors+Show Affiliations

Department of Respiratory Sciences, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16162791

Citation

Sun, Yi-Lan, et al. "Effect of Beta-blockers On Cardiac Function and Calcium Handling Protein in Postinfarction Heart Failure Rats." Chest, vol. 128, no. 3, 2005, pp. 1812-21.
Sun YL, Hu SJ, Wang LH, et al. Effect of beta-blockers on cardiac function and calcium handling protein in postinfarction heart failure rats. Chest. 2005;128(3):1812-21.
Sun, Y. L., Hu, S. J., Wang, L. H., Hu, Y., & Zhou, J. Y. (2005). Effect of beta-blockers on cardiac function and calcium handling protein in postinfarction heart failure rats. Chest, 128(3), 1812-21.
Sun YL, et al. Effect of Beta-blockers On Cardiac Function and Calcium Handling Protein in Postinfarction Heart Failure Rats. Chest. 2005;128(3):1812-21. PubMed PMID: 16162791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of beta-blockers on cardiac function and calcium handling protein in postinfarction heart failure rats. AU - Sun,Yi-Lan, AU - Hu,Shen-Jiang, AU - Wang,Li-Hong, AU - Hu,Ying, AU - Zhou,Jian-Ying, PY - 2005/9/16/pubmed PY - 2005/11/9/medline PY - 2005/9/16/entrez SP - 1812 EP - 21 JF - Chest JO - Chest VL - 128 IS - 3 N2 - OBJECTIVES: The normal expression of Ca2+-handling protein is critical for efficient myocardial function. The present study was designed to test the hypothesis that beta-blocker treatment may attenuate left ventricular (LV) remodeling and cardiac contractile dysfunction in the failing heart, which may be associated with alterations of Ca2+-handling protein METHODS: We investigated the change of LV remodeling and function in a rat model of heart failure due to myocardial infarction (MI) with or without carvedilol (30 mg/kg/d) or metoprolol (60 mg/kg/d) treatment for 6 weeks (n = 9 in the MI plus carvedilol group, and n = 8 in every other group). The expression of messenger RNA and proteins of sarcoplasmic reticulum Ca2+-adenosine triphosphatase (SERCA) and phospholamban in cardiomyocytes of all rats were also measured RESULTS: There was significant LV remodeling and cardiac contractile dysfunction in MI rats. The messenger RNA and protein expression of SERCA were down-regulated (p < 0.01), but the expression of phospholamban messenger RNA and protein were up-regulated (p < 0.01) in MI rats compared to sham-operated rats. After the treatment with beta-blockers, LV remodeling and function were clearly improved. Carvedilol was better in attenuating the weight of the LV and the relative weight of the right ventricle than metoprolol (p < 0.05). beta-Blockers restored the low expression of SERCA (p < 0.05) but showed no effect on phospholamban expression (p > 0.05). Moreover, carvedilol induced a more significant improvement of SERCA expression than metoprolol (p < 0.05) CONCLUSIONS: Beta-blockers are effective in preventing LV remodeling and cardiac contractile dysfunction in the failing heart. The molecular mechanism may be related to normalization of SERCA expression. SN - 0012-3692 UR - https://www.unboundmedicine.com/medline/citation/16162791/Effect_of_beta_blockers_on_cardiac_function_and_calcium_handling_protein_in_postinfarction_heart_failure_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0012-3692(15)52221-6 DB - PRIME DP - Unbound Medicine ER -