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A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos).
Altern Med Rev 2005; 10(3):193-203AM

Abstract

Certain of the water-soluble flavonoid molecules can be converted into lipid-compatible molecular complexes, aptly called phytosomes. Phytosomes are better able to transition from a hydrophilic environment into the lipid-friendly environment of the outer cell membrane, and from there into the cell, finally reaching the blood. The fruit of the milk thistle plant (Silybum marianum, Family Asteraceae) contains flavonoids that are proven liver protectants. The standardized extract known as silymarin contains three flavonoids of the flavonol subclass. Silybin predominates, followed by silydianin and silychristin. Although silybin is the most potent of the flavonoids in milk thistle, similar to other flavonoids it is not well-absorbed. Silybin-phosphatidylcholine complexed as a phytosome provides significant liver protection and enhanced bioavailability over conventional silymarin.

Authors+Show Affiliations

University of California, Berkeley, USA. dockidd@dockidd.comNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16164374

Citation

Kidd, Parris, and Kathleen Head. "A Review of the Bioavailability and Clinical Efficacy of Milk Thistle Phytosome: a Silybin-phosphatidylcholine Complex (Siliphos)." Alternative Medicine Review : a Journal of Clinical Therapeutic, vol. 10, no. 3, 2005, pp. 193-203.
Kidd P, Head K. A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos). Altern Med Rev. 2005;10(3):193-203.
Kidd, P., & Head, K. (2005). A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos). Alternative Medicine Review : a Journal of Clinical Therapeutic, 10(3), pp. 193-203.
Kidd P, Head K. A Review of the Bioavailability and Clinical Efficacy of Milk Thistle Phytosome: a Silybin-phosphatidylcholine Complex (Siliphos). Altern Med Rev. 2005;10(3):193-203. PubMed PMID: 16164374.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos). AU - Kidd,Parris, AU - Head,Kathleen, PY - 2005/9/17/pubmed PY - 2005/12/13/medline PY - 2005/9/17/entrez SP - 193 EP - 203 JF - Alternative medicine review : a journal of clinical therapeutic JO - Altern Med Rev VL - 10 IS - 3 N2 - Certain of the water-soluble flavonoid molecules can be converted into lipid-compatible molecular complexes, aptly called phytosomes. Phytosomes are better able to transition from a hydrophilic environment into the lipid-friendly environment of the outer cell membrane, and from there into the cell, finally reaching the blood. The fruit of the milk thistle plant (Silybum marianum, Family Asteraceae) contains flavonoids that are proven liver protectants. The standardized extract known as silymarin contains three flavonoids of the flavonol subclass. Silybin predominates, followed by silydianin and silychristin. Although silybin is the most potent of the flavonoids in milk thistle, similar to other flavonoids it is not well-absorbed. Silybin-phosphatidylcholine complexed as a phytosome provides significant liver protection and enhanced bioavailability over conventional silymarin. SN - 1089-5159 UR - https://www.unboundmedicine.com/medline/citation/16164374/A_review_of_the_bioavailability_and_clinical_efficacy_of_milk_thistle_phytosome:_a_silybin_phosphatidylcholine_complex__Siliphos__ L2 - http://archive.foundationalmedicinereview.com/publications/10/3/193.pdf DB - PRIME DP - Unbound Medicine ER -