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Increased interferon-gamma- and interleukin-4-synthesizing subsets of circulating T lymphocytes in pregnant asthmatics.
Clin Exp Allergy 2005; 35(9):1197-203CE

Abstract

BACKGROUND

Pregnancy frequently interferes with the course of bronchial asthma, and asthmatic pregnant women experience less successful pregnancies. T lymphocytes synthesizing IL-4 or IFN-gamma are important in allergic mechanisms of the airways as well as in materno-fetal immunity.

OBJECTIVE

We hypothesized that pregnancy (a T helper-2 polarized state) of asthmatics will enhance the number of circulating T2 lymphocytes, but decrease the subset-producing IFN-gamma (T1 lymphocytes) and thereby cause a culminating T2 dominance with possible clinical consequences.

METHODS

IL-4- or IFN-gamma-producing T lymphocytes were determined by flow cytometry in healthy (n=8) and asthmatic (n=13) non-pregnant women and healthy (n=18) and asthmatic (n=48) pregnant women of similar chronological and gestational (2nd-3rd trimester) age and asthma severity (Global Initiative for Asthma II-III).

RESULTS

In the blood of non-pregnant women--healthy or asthmatic--the numbers of IL-4- and IFN-gamma+ T cells were very low (<10/microL blood). In contrast, in asthmatic pregnant women, the cell counts were 182+/-27 and 39+/-6 for IFN-gamma+ and IL-4+ T cells/microL blood, respectively (both P<0.05 vs. respective control values of non-pregnant asthmatics). Within the asthmatic pregnant group, significant negative correlations were revealed between the numbers of IFN-gamma+ or IL-4+ T cells and maternal peak expiratory flow as well as birth weight of newborns (both P<0.05).

CONCLUSION

These data show a previously unknown immunological interference between asthma and pregnancy. The culminating proliferation of IFN-gamma+ and IL-4+ T lymphocytes may potentially impair maternal airway symptoms as well as fetal development.

Authors+Show Affiliations

Department of Pulmonology, Semmelweis University, Diós árok 1/C, 1125 Budapest, Hungary.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16164448

Citation

Tamási, L, et al. "Increased Interferon-gamma- and Interleukin-4-synthesizing Subsets of Circulating T Lymphocytes in Pregnant Asthmatics." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 35, no. 9, 2005, pp. 1197-203.
Tamási L, Bohács A, Pállinger E, et al. Increased interferon-gamma- and interleukin-4-synthesizing subsets of circulating T lymphocytes in pregnant asthmatics. Clin Exp Allergy. 2005;35(9):1197-203.
Tamási, L., Bohács, A., Pállinger, E., Falus, A., Rigó, J., Müller, V., ... Losonczy, G. (2005). Increased interferon-gamma- and interleukin-4-synthesizing subsets of circulating T lymphocytes in pregnant asthmatics. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 35(9), pp. 1197-203.
Tamási L, et al. Increased Interferon-gamma- and Interleukin-4-synthesizing Subsets of Circulating T Lymphocytes in Pregnant Asthmatics. Clin Exp Allergy. 2005;35(9):1197-203. PubMed PMID: 16164448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased interferon-gamma- and interleukin-4-synthesizing subsets of circulating T lymphocytes in pregnant asthmatics. AU - Tamási,L, AU - Bohács,A, AU - Pállinger,E, AU - Falus,A, AU - Rigó,J,Jr AU - Müller,V, AU - Komlósi,Z, AU - Magyar,P, AU - Losonczy,G, PY - 2005/9/17/pubmed PY - 2006/1/18/medline PY - 2005/9/17/entrez SP - 1197 EP - 203 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 35 IS - 9 N2 - BACKGROUND: Pregnancy frequently interferes with the course of bronchial asthma, and asthmatic pregnant women experience less successful pregnancies. T lymphocytes synthesizing IL-4 or IFN-gamma are important in allergic mechanisms of the airways as well as in materno-fetal immunity. OBJECTIVE: We hypothesized that pregnancy (a T helper-2 polarized state) of asthmatics will enhance the number of circulating T2 lymphocytes, but decrease the subset-producing IFN-gamma (T1 lymphocytes) and thereby cause a culminating T2 dominance with possible clinical consequences. METHODS: IL-4- or IFN-gamma-producing T lymphocytes were determined by flow cytometry in healthy (n=8) and asthmatic (n=13) non-pregnant women and healthy (n=18) and asthmatic (n=48) pregnant women of similar chronological and gestational (2nd-3rd trimester) age and asthma severity (Global Initiative for Asthma II-III). RESULTS: In the blood of non-pregnant women--healthy or asthmatic--the numbers of IL-4- and IFN-gamma+ T cells were very low (<10/microL blood). In contrast, in asthmatic pregnant women, the cell counts were 182+/-27 and 39+/-6 for IFN-gamma+ and IL-4+ T cells/microL blood, respectively (both P<0.05 vs. respective control values of non-pregnant asthmatics). Within the asthmatic pregnant group, significant negative correlations were revealed between the numbers of IFN-gamma+ or IL-4+ T cells and maternal peak expiratory flow as well as birth weight of newborns (both P<0.05). CONCLUSION: These data show a previously unknown immunological interference between asthma and pregnancy. The culminating proliferation of IFN-gamma+ and IL-4+ T lymphocytes may potentially impair maternal airway symptoms as well as fetal development. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/16164448/Increased_interferon_gamma__and_interleukin_4_synthesizing_subsets_of_circulating_T_lymphocytes_in_pregnant_asthmatics_ L2 - https://doi.org/10.1111/j.1365-2222.2005.02322.x DB - PRIME DP - Unbound Medicine ER -