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Treatment of full-thickness chondral defects with autologous chondrocyte implantation.

Abstract

Autologous chondrocyte implantation (ACI) is a reproducible treatment option for large full-thickness symptomatic chondral injuries with appropriate knowledge of technique and patient selection. It provides a cellular repair that offers a high percentage of good to excellent clinical results over a long follow-up period. It is applicable over a wide range of chondral injuries from simple to more complex lesions. It is essential that the intra-articular environment be as close to normal as possible for successful cartilage repair. Coexisting knee pathology must be aggressively treated. ACI does have a prolonged postoperative rehabilitation course necessitated by the biologic nature of the repair, and patients must be able to comply with the rehabilitation and temporary restrictions required for a successful outcome.

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  • Authors+Show Affiliations

    ,

    Atlanta Sports Medicine and Orthopaedic Center, 3200 Downwood Circle, Suite 500, Atlanta, GA 30327, USA. sdg14@mindspring.com

    Source

    MeSH

    Cartilage Diseases
    Cartilage, Articular
    Cell Transplantation
    Chondrocytes
    Humans
    Joint Diseases
    Orthopedic Procedures
    Patient Selection
    Transplantation, Autologous

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    16164949

    Citation

    Gillogly, Scott D., and Thomas H. Myers. "Treatment of Full-thickness Chondral Defects With Autologous Chondrocyte Implantation." The Orthopedic Clinics of North America, vol. 36, no. 4, 2005, pp. 433-46.
    Gillogly SD, Myers TH. Treatment of full-thickness chondral defects with autologous chondrocyte implantation. Orthop Clin North Am. 2005;36(4):433-46.
    Gillogly, S. D., & Myers, T. H. (2005). Treatment of full-thickness chondral defects with autologous chondrocyte implantation. The Orthopedic Clinics of North America, 36(4), pp. 433-46.
    Gillogly SD, Myers TH. Treatment of Full-thickness Chondral Defects With Autologous Chondrocyte Implantation. Orthop Clin North Am. 2005;36(4):433-46. PubMed PMID: 16164949.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Treatment of full-thickness chondral defects with autologous chondrocyte implantation. AU - Gillogly,Scott D, AU - Myers,Thomas H, PY - 2005/9/17/pubmed PY - 2005/12/13/medline PY - 2005/9/17/entrez SP - 433 EP - 46 JF - The Orthopedic clinics of North America JO - Orthop. Clin. North Am. VL - 36 IS - 4 N2 - Autologous chondrocyte implantation (ACI) is a reproducible treatment option for large full-thickness symptomatic chondral injuries with appropriate knowledge of technique and patient selection. It provides a cellular repair that offers a high percentage of good to excellent clinical results over a long follow-up period. It is applicable over a wide range of chondral injuries from simple to more complex lesions. It is essential that the intra-articular environment be as close to normal as possible for successful cartilage repair. Coexisting knee pathology must be aggressively treated. ACI does have a prolonged postoperative rehabilitation course necessitated by the biologic nature of the repair, and patients must be able to comply with the rehabilitation and temporary restrictions required for a successful outcome. SN - 0030-5898 UR - https://www.unboundmedicine.com/medline/citation/16164949/Treatment_of_full_thickness_chondral_defects_with_autologous_chondrocyte_implantation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0030-5898(05)00071-4 DB - PRIME DP - Unbound Medicine ER -