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Five-year incidence and progression of vascular retinopathy in persons without diabetes: the Blue Mountains Eye Study.
Eye (Lond) 2006; 20(11):1239-45E

Abstract

PURPOSE

To assess the 5-year incidence of vascular retinopathy and its associations in an older nondiabetic population.

METHODS

The Blue Mountains Eye Study examined 3654 residents aged 49+ years (82.4% response rate) during 1992-1994, and re-examined 2335 (75.1% of survivors) during 1997-1999. Retinopathy lesions (microaneurysms, haemorrhages, hard or soft exudates) were assessed from 6-field retinal photographs in persons without diabetes. Incident retinopathy was assessed in those at risk. Hypertensive status was defined following the WHO/International Society of Hypertension guidelines.

RESULTS

Of the 2335 re-examined, 195 had retinopathy lesions at baseline and 1725 were at risk of retinopathy after excluding subjects with diabetes (n=261), retinal vein occlusion (n=52) or missing/un-gradable photographs (n=102). The cumulative 5-year incidence was 9.7% (95% confidence intervals (CI) 8.3-11.1%). Age was the only factor significantly associated with incident retinopathy (Pfor trend=0.012). Neither fasting blood glucose (age-sex-adjusted P=0.147) nor hypertension (adjusted Pfor trend=0.43) was associated with incident retinopathy. Of the 195 with retinopathy lesions at baseline, 3.5% developed diabetes, 13.3% progressed, and 72.3% regressed/disappeared over 5 years. Progression was positively associated with elevated blood pressure (BP) (adjusted odds ratio (OR) 1.3, 95% CI 1.1-1.6 per 10 mmHg systolic BP) and inversely associated with fasting glucose level (OR 0.36, CI 0.14-0.92 per mmol/l increase). Aspirin use was weakly associated with regression (OR 2.4, CI 1.0-6.0).

CONCLUSIONS

Over 5 years, retinopathy developed in 10% of older people without diabetes, while 72% of baseline lesions regressed. Age was significantly associated with the development of these lesions.

Authors+Show Affiliations

Department of Ophthalmology, Centre for Vision Research, University of Sydney, Sydney, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16167076

Citation

Cugati, S, et al. "Five-year Incidence and Progression of Vascular Retinopathy in Persons Without Diabetes: the Blue Mountains Eye Study." Eye (London, England), vol. 20, no. 11, 2006, pp. 1239-45.
Cugati S, Cikamatana L, Wang JJ, et al. Five-year incidence and progression of vascular retinopathy in persons without diabetes: the Blue Mountains Eye Study. Eye (Lond). 2006;20(11):1239-45.
Cugati, S., Cikamatana, L., Wang, J. J., Kifley, A., Liew, G., & Mitchell, P. (2006). Five-year incidence and progression of vascular retinopathy in persons without diabetes: the Blue Mountains Eye Study. Eye (London, England), 20(11), pp. 1239-45.
Cugati S, et al. Five-year Incidence and Progression of Vascular Retinopathy in Persons Without Diabetes: the Blue Mountains Eye Study. Eye (Lond). 2006;20(11):1239-45. PubMed PMID: 16167076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Five-year incidence and progression of vascular retinopathy in persons without diabetes: the Blue Mountains Eye Study. AU - Cugati,S, AU - Cikamatana,L, AU - Wang,J J, AU - Kifley,A, AU - Liew,G, AU - Mitchell,P, Y1 - 2005/09/16/ PY - 2005/9/17/pubmed PY - 2007/1/19/medline PY - 2005/9/17/entrez SP - 1239 EP - 45 JF - Eye (London, England) JO - Eye (Lond) VL - 20 IS - 11 N2 - PURPOSE: To assess the 5-year incidence of vascular retinopathy and its associations in an older nondiabetic population. METHODS: The Blue Mountains Eye Study examined 3654 residents aged 49+ years (82.4% response rate) during 1992-1994, and re-examined 2335 (75.1% of survivors) during 1997-1999. Retinopathy lesions (microaneurysms, haemorrhages, hard or soft exudates) were assessed from 6-field retinal photographs in persons without diabetes. Incident retinopathy was assessed in those at risk. Hypertensive status was defined following the WHO/International Society of Hypertension guidelines. RESULTS: Of the 2335 re-examined, 195 had retinopathy lesions at baseline and 1725 were at risk of retinopathy after excluding subjects with diabetes (n=261), retinal vein occlusion (n=52) or missing/un-gradable photographs (n=102). The cumulative 5-year incidence was 9.7% (95% confidence intervals (CI) 8.3-11.1%). Age was the only factor significantly associated with incident retinopathy (Pfor trend=0.012). Neither fasting blood glucose (age-sex-adjusted P=0.147) nor hypertension (adjusted Pfor trend=0.43) was associated with incident retinopathy. Of the 195 with retinopathy lesions at baseline, 3.5% developed diabetes, 13.3% progressed, and 72.3% regressed/disappeared over 5 years. Progression was positively associated with elevated blood pressure (BP) (adjusted odds ratio (OR) 1.3, 95% CI 1.1-1.6 per 10 mmHg systolic BP) and inversely associated with fasting glucose level (OR 0.36, CI 0.14-0.92 per mmol/l increase). Aspirin use was weakly associated with regression (OR 2.4, CI 1.0-6.0). CONCLUSIONS: Over 5 years, retinopathy developed in 10% of older people without diabetes, while 72% of baseline lesions regressed. Age was significantly associated with the development of these lesions. SN - 0950-222X UR - https://www.unboundmedicine.com/medline/citation/16167076/Five_year_incidence_and_progression_of_vascular_retinopathy_in_persons_without_diabetes:_the_Blue_Mountains_Eye_Study_ L2 - http://dx.doi.org/10.1038/sj.eye.6702085 DB - PRIME DP - Unbound Medicine ER -