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Effect of iron supplementation on serum zinc status of lactating women in Addis Ababa, Ethiopia.
East Afr Med J. 2005 Jul; 82(7):349-52.EA

Abstract

OBJECTIVE

To evaluate the impact of daily and weekly iron supplementation on serum zinc status among anaemic lactating mothers.

DESIGN

A randomised iron intervention controlled trial.

SETTING

Seven urban slum communities of Addis Ababa.

SUBJECTS

Phase one of the study involved 207 anaemic lactating women assigned into two intervention groups; the daily (N=71) and weekly (N=71) Iron supplemented and the control group (N=68). Supplementation with 60 mg tablet containing 300 microg ferrous sulphate and 400 microg folic acid was done for three months while the control group was n otsupplemented. Phase two involved 53 participants systematically drawn from phase one.

MAIN OUTCOME MEASURES

Haemoglobin from all subjects and serum zinc and ferittin levels following three months supplementation. Zinc status based on serum zinc value of less than 10.7% micromole/L.

RESULTS

The mean baseline characteristics and serum zinc of the women at baseline were similar, overall marginal zinc deficiency prevalence was 11.3% and no zinc deficiency was detected. Following supplementation, zinc deficiency was detected in the supplemented groups but not in the control group. The mean serum zinc significantly changed in both supplemented groups while no change was observed in the control group. The reduction in the mean serum zinc was significantly higher in the daily than in the weekly supplemented group.

CONCLUSION

Iron supplementation impacts negatively on serum zinc status (exacerbates zinc deficiency) and hence, its contribution to zinc deficiency deserves further investigation especially in the context of the on-going promotion of double fortification strategies that involve iron.

Authors+Show Affiliations

Ethiopian Health and Nutrition Research Institute, P.O. Box 5654, Addis Ababa, Ethiopia.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16167707

Citation

Haidar, J, et al. "Effect of Iron Supplementation On Serum Zinc Status of Lactating Women in Addis Ababa, Ethiopia." East African Medical Journal, vol. 82, no. 7, 2005, pp. 349-52.
Haidar J, Umeta M, Kogi-Makau W. Effect of iron supplementation on serum zinc status of lactating women in Addis Ababa, Ethiopia. East Afr Med J. 2005;82(7):349-52.
Haidar, J., Umeta, M., & Kogi-Makau, W. (2005). Effect of iron supplementation on serum zinc status of lactating women in Addis Ababa, Ethiopia. East African Medical Journal, 82(7), 349-52.
Haidar J, Umeta M, Kogi-Makau W. Effect of Iron Supplementation On Serum Zinc Status of Lactating Women in Addis Ababa, Ethiopia. East Afr Med J. 2005;82(7):349-52. PubMed PMID: 16167707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of iron supplementation on serum zinc status of lactating women in Addis Ababa, Ethiopia. AU - Haidar,J, AU - Umeta,M, AU - Kogi-Makau,W, PY - 2005/9/20/pubmed PY - 2005/12/13/medline PY - 2005/9/20/entrez SP - 349 EP - 52 JF - East African medical journal JO - East Afr Med J VL - 82 IS - 7 N2 - OBJECTIVE: To evaluate the impact of daily and weekly iron supplementation on serum zinc status among anaemic lactating mothers. DESIGN: A randomised iron intervention controlled trial. SETTING: Seven urban slum communities of Addis Ababa. SUBJECTS: Phase one of the study involved 207 anaemic lactating women assigned into two intervention groups; the daily (N=71) and weekly (N=71) Iron supplemented and the control group (N=68). Supplementation with 60 mg tablet containing 300 microg ferrous sulphate and 400 microg folic acid was done for three months while the control group was n otsupplemented. Phase two involved 53 participants systematically drawn from phase one. MAIN OUTCOME MEASURES: Haemoglobin from all subjects and serum zinc and ferittin levels following three months supplementation. Zinc status based on serum zinc value of less than 10.7% micromole/L. RESULTS: The mean baseline characteristics and serum zinc of the women at baseline were similar, overall marginal zinc deficiency prevalence was 11.3% and no zinc deficiency was detected. Following supplementation, zinc deficiency was detected in the supplemented groups but not in the control group. The mean serum zinc significantly changed in both supplemented groups while no change was observed in the control group. The reduction in the mean serum zinc was significantly higher in the daily than in the weekly supplemented group. CONCLUSION: Iron supplementation impacts negatively on serum zinc status (exacerbates zinc deficiency) and hence, its contribution to zinc deficiency deserves further investigation especially in the context of the on-going promotion of double fortification strategies that involve iron. SN - 0012-835X UR - https://www.unboundmedicine.com/medline/citation/16167707/Effect_of_iron_supplementation_on_serum_zinc_status_of_lactating_women_in_Addis_Ababa_Ethiopia_ L2 - https://medlineplus.gov/dietarysupplements.html DB - PRIME DP - Unbound Medicine ER -