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Germline polymorphism of p53 codon 72 in gynecological cancer.
Gynecol Oncol. 2006 Jan; 100(1):173-8.GO

Abstract

OBJECTIVE

To investigate the biological significance of single nucleotide polymorphism at codon 72 of the p53 gene in the development of gynecological cancer.

METHODS

p53 codon 72 polymorphism was examined in a total of 354 blood samples from 95 normal, 83 cervical, 108 endometrial and 68 ovarian cancer cases using polymerase chain reaction and restriction fragment length polymorphism techniques.

RESULTS

When p53 codon 72 genotype was classified into two subgroups of Arg/Arg and Arg/Pro + Pro/Pro, the Arg/Arg genotype was associated with an increased risk for the development of endometrial cancer (OR = 1.86, 95% CI = 1.06 to 3.26) compared with the Arg/Pro + Pro/Pro genotype (P = 0.0301). The Arg allele also increased the risk of endometrial cancer (OR = 1.42, 95% CI = 0.93 to 1.52) compared with the Pro allele, but no statistical difference was found (P = 0.1031). There was no significant difference in the genotype or allele prevalence between control subjects and cervical or ovarian cancer patients.

CONCLUSION

Homozygous Arg at codon 72 of the p53 gene may be a risk factor for developing endometrial cancer in a Japanese population.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigakumachi, Takatsuki Osaka 569-8686, Japan. gyn017@poh.osaka-med.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16168468

Citation

Ueda, Masatsugu, et al. "Germline Polymorphism of P53 Codon 72 in Gynecological Cancer." Gynecologic Oncology, vol. 100, no. 1, 2006, pp. 173-8.
Ueda M, Terai Y, Kanda K, et al. Germline polymorphism of p53 codon 72 in gynecological cancer. Gynecol Oncol. 2006;100(1):173-8.
Ueda, M., Terai, Y., Kanda, K., Kanemura, M., Takehara, M., Yamaguchi, H., Nishiyama, K., Yasuda, M., & Ueki, M. (2006). Germline polymorphism of p53 codon 72 in gynecological cancer. Gynecologic Oncology, 100(1), 173-8.
Ueda M, et al. Germline Polymorphism of P53 Codon 72 in Gynecological Cancer. Gynecol Oncol. 2006;100(1):173-8. PubMed PMID: 16168468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Germline polymorphism of p53 codon 72 in gynecological cancer. AU - Ueda,Masatsugu, AU - Terai,Yoshito, AU - Kanda,Koji, AU - Kanemura,Masanori, AU - Takehara,Mikio, AU - Yamaguchi,Hiroyuki, AU - Nishiyama,Koji, AU - Yasuda,Masayuki, AU - Ueki,Minoru, Y1 - 2005/09/15/ PY - 2005/04/25/received PY - 2005/08/05/revised PY - 2005/08/17/accepted PY - 2005/9/20/pubmed PY - 2006/2/10/medline PY - 2005/9/20/entrez SP - 173 EP - 8 JF - Gynecologic oncology JO - Gynecol Oncol VL - 100 IS - 1 N2 - OBJECTIVE: To investigate the biological significance of single nucleotide polymorphism at codon 72 of the p53 gene in the development of gynecological cancer. METHODS: p53 codon 72 polymorphism was examined in a total of 354 blood samples from 95 normal, 83 cervical, 108 endometrial and 68 ovarian cancer cases using polymerase chain reaction and restriction fragment length polymorphism techniques. RESULTS: When p53 codon 72 genotype was classified into two subgroups of Arg/Arg and Arg/Pro + Pro/Pro, the Arg/Arg genotype was associated with an increased risk for the development of endometrial cancer (OR = 1.86, 95% CI = 1.06 to 3.26) compared with the Arg/Pro + Pro/Pro genotype (P = 0.0301). The Arg allele also increased the risk of endometrial cancer (OR = 1.42, 95% CI = 0.93 to 1.52) compared with the Pro allele, but no statistical difference was found (P = 0.1031). There was no significant difference in the genotype or allele prevalence between control subjects and cervical or ovarian cancer patients. CONCLUSION: Homozygous Arg at codon 72 of the p53 gene may be a risk factor for developing endometrial cancer in a Japanese population. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/16168468/Germline_polymorphism_of_p53_codon_72_in_gynecological_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(05)00713-4 DB - PRIME DP - Unbound Medicine ER -