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Essential oil analysis and anticancer activity of leaf essential oil of Croton flavens L. from Guadeloupe.
J Ethnopharmacol. 2006 Jan 03; 103(1):99-102.JE

Abstract

The leaf essential oil of Croton flavens L., a native plant from the Caribbean area used in traditional medicine, was extracted by hydrodistillation. The composition of the volatile fraction of this essential oil was determined by GC and GC-MS analyses. We have identified 47 compounds, of which viridiflorene (12.22%), germacrone (5.27%), (E)-gamma-bisabolene (5.25%) and beta-caryophyllene (4.95%) are the main components. The anticancer activity of this extract was tested on human lung carcinoma cell line A-549 and human colon adenocarcinoma cell line DLD-1. Croton flavens leaf essential oil was found to be very active against both tumor cell lines, with a GI(50) of 27 +/- 4 microg/ml for A-549 and 28 +/- 3 microg/ml for DLD-1. Three compounds identified in the leaf essential oil, alpha-cadinol (3.97%), beta-elemene (1.53%) and alpha-humulene (1.06%) are cytotoxic against tumor cell lines.

Authors+Show Affiliations

Sylvestre M
Laboratoire d'analyse et de séparation des essences végétales, Département des Sciences fondamentales, Université du Québec à Chicoutimi, Qué., Canada.
Pichette A
No affiliation info available
Longtin A
No affiliation info available
Nagau F
No affiliation info available
Legault J
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicCell Line, TumorCrotonHumansOils, VolatilePlant Leaves

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16168586

Citation

Sylvestre, Muriel, et al. "Essential Oil Analysis and Anticancer Activity of Leaf Essential Oil of Croton Flavens L. From Guadeloupe." Journal of Ethnopharmacology, vol. 103, no. 1, 2006, pp. 99-102.
Sylvestre M, Pichette A, Longtin A, et al. Essential oil analysis and anticancer activity of leaf essential oil of Croton flavens L. from Guadeloupe. J Ethnopharmacol. 2006;103(1):99-102.
Sylvestre, M., Pichette, A., Longtin, A., Nagau, F., & Legault, J. (2006). Essential oil analysis and anticancer activity of leaf essential oil of Croton flavens L. from Guadeloupe. Journal of Ethnopharmacology, 103(1), 99-102.
Sylvestre M, et al. Essential Oil Analysis and Anticancer Activity of Leaf Essential Oil of Croton Flavens L. From Guadeloupe. J Ethnopharmacol. 2006 Jan 3;103(1):99-102. PubMed PMID: 16168586.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Essential oil analysis and anticancer activity of leaf essential oil of Croton flavens L. from Guadeloupe. AU - Sylvestre,Muriel, AU - Pichette,André, AU - Longtin,Angélique, AU - Nagau,Francine, AU - Legault,Jean, Y1 - 2005/09/15/ PY - 2004/10/22/received PY - 2005/06/08/revised PY - 2005/07/26/accepted PY - 2005/9/20/pubmed PY - 2006/3/17/medline PY - 2005/9/20/entrez SP - 99 EP - 102 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 103 IS - 1 N2 - The leaf essential oil of Croton flavens L., a native plant from the Caribbean area used in traditional medicine, was extracted by hydrodistillation. The composition of the volatile fraction of this essential oil was determined by GC and GC-MS analyses. We have identified 47 compounds, of which viridiflorene (12.22%), germacrone (5.27%), (E)-gamma-bisabolene (5.25%) and beta-caryophyllene (4.95%) are the main components. The anticancer activity of this extract was tested on human lung carcinoma cell line A-549 and human colon adenocarcinoma cell line DLD-1. Croton flavens leaf essential oil was found to be very active against both tumor cell lines, with a GI(50) of 27 +/- 4 microg/ml for A-549 and 28 +/- 3 microg/ml for DLD-1. Three compounds identified in the leaf essential oil, alpha-cadinol (3.97%), beta-elemene (1.53%) and alpha-humulene (1.06%) are cytotoxic against tumor cell lines. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/16168586/Essential_oil_analysis_and_anticancer_activity_of_leaf_essential_oil_of_Croton_flavens_L__from_Guadeloupe_ DB - PRIME DP - Unbound Medicine ER -