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Protective effects of zinc on lipid peroxidation, antioxidant enzymes and hepatic histoarchitecture in chlorpyrifos-induced toxicity.
Chem Biol Interact 2005; 156(2-3):131-40CB

Abstract

The present study investigated the hepatoprotective role of zinc in attenuating the toxicity induced by chlorpyrifos in rat liver. Male Sprague-Dawley (SD) rats received either oral chlorpyrifos (13.5mg/kg body weight), zinc alone (227mg/l in drinking water) or combined chlorpyrifos plus zinc treatment for a total duration of 8 weeks. The effects of these treatments were studied on various parameters in rat liver, including lipid peroxidation, antioxidant enzymes, levels of metallothionein (MT) and hepatic histoarchitecture. Chlorpyrifos treatment resulted in a significant increase in hepatic lipid peroxidation and activities of superoxide dismutase (SOD), glutathione peroxidase (G-Px) and glutathione reductase (GR). On the contrary, chlorpyrifos intoxication caused a significant inhibition in the levels of reduced glutathione (GSH), catalase (CAT) and glutathione-S-transferase (GST) activities. However, zinc treatment to chlorpyrifos-intoxicated animals normalized the otherwise raised levels of lipid peroxidation to within normal limits. Moreover, zinc treatment to these animals resulted in an elevation in the levels of GSH, catalase and GST, as well as a significant decrease in the levels of SOD. Levels of MT were also found to be depressed in chlorpyrifos-treated animals, but tended to increase following co-administration of zinc. Additionally, chlorpyrifos-treated animals demonstrated increased vacuolization, necrosis and ballooning of the hepatocytes and dilatation of sinusoids as well as increase in the number of binucleated cells. However, zinc administration to chlorpyrifos-treated animals resulted in overall improvement in the hepatic histoarchitecture, emphasizing the protective potential of zinc. Hence, the present study suggests the protective potential of zinc in alleviating the hepatic toxicity induced by chlorpyrifos.

Authors+Show Affiliations

Department of Biophysics, Panjab University, Sector 14, Chandigarh 160014, India. ajayg@baylorhealth.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16169541

Citation

Goel, Ajay, et al. "Protective Effects of Zinc On Lipid Peroxidation, Antioxidant Enzymes and Hepatic Histoarchitecture in Chlorpyrifos-induced Toxicity." Chemico-biological Interactions, vol. 156, no. 2-3, 2005, pp. 131-40.
Goel A, Dani V, Dhawan DK. Protective effects of zinc on lipid peroxidation, antioxidant enzymes and hepatic histoarchitecture in chlorpyrifos-induced toxicity. Chem Biol Interact. 2005;156(2-3):131-40.
Goel, A., Dani, V., & Dhawan, D. K. (2005). Protective effects of zinc on lipid peroxidation, antioxidant enzymes and hepatic histoarchitecture in chlorpyrifos-induced toxicity. Chemico-biological Interactions, 156(2-3), pp. 131-40.
Goel A, Dani V, Dhawan DK. Protective Effects of Zinc On Lipid Peroxidation, Antioxidant Enzymes and Hepatic Histoarchitecture in Chlorpyrifos-induced Toxicity. Chem Biol Interact. 2005 Oct 20;156(2-3):131-40. PubMed PMID: 16169541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of zinc on lipid peroxidation, antioxidant enzymes and hepatic histoarchitecture in chlorpyrifos-induced toxicity. AU - Goel,Ajay, AU - Dani,Vijayta, AU - Dhawan,D K, PY - 2005/06/14/received PY - 2005/08/08/revised PY - 2005/08/16/accepted PY - 2005/9/20/pubmed PY - 2005/11/16/medline PY - 2005/9/20/entrez SP - 131 EP - 40 JF - Chemico-biological interactions JO - Chem. Biol. Interact. VL - 156 IS - 2-3 N2 - The present study investigated the hepatoprotective role of zinc in attenuating the toxicity induced by chlorpyrifos in rat liver. Male Sprague-Dawley (SD) rats received either oral chlorpyrifos (13.5mg/kg body weight), zinc alone (227mg/l in drinking water) or combined chlorpyrifos plus zinc treatment for a total duration of 8 weeks. The effects of these treatments were studied on various parameters in rat liver, including lipid peroxidation, antioxidant enzymes, levels of metallothionein (MT) and hepatic histoarchitecture. Chlorpyrifos treatment resulted in a significant increase in hepatic lipid peroxidation and activities of superoxide dismutase (SOD), glutathione peroxidase (G-Px) and glutathione reductase (GR). On the contrary, chlorpyrifos intoxication caused a significant inhibition in the levels of reduced glutathione (GSH), catalase (CAT) and glutathione-S-transferase (GST) activities. However, zinc treatment to chlorpyrifos-intoxicated animals normalized the otherwise raised levels of lipid peroxidation to within normal limits. Moreover, zinc treatment to these animals resulted in an elevation in the levels of GSH, catalase and GST, as well as a significant decrease in the levels of SOD. Levels of MT were also found to be depressed in chlorpyrifos-treated animals, but tended to increase following co-administration of zinc. Additionally, chlorpyrifos-treated animals demonstrated increased vacuolization, necrosis and ballooning of the hepatocytes and dilatation of sinusoids as well as increase in the number of binucleated cells. However, zinc administration to chlorpyrifos-treated animals resulted in overall improvement in the hepatic histoarchitecture, emphasizing the protective potential of zinc. Hence, the present study suggests the protective potential of zinc in alleviating the hepatic toxicity induced by chlorpyrifos. SN - 0009-2797 UR - https://www.unboundmedicine.com/medline/citation/16169541/Protective_effects_of_zinc_on_lipid_peroxidation_antioxidant_enzymes_and_hepatic_histoarchitecture_in_chlorpyrifos_induced_toxicity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-2797(05)00204-8 DB - PRIME DP - Unbound Medicine ER -