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Fine mapping of the multiple sclerosis susceptibility locus on 5p14-p12.
J Neuroimmunol. 2005 Dec 30; 170(1-2):122-33.JN

Abstract

Linkage analyses have identified four major MS susceptibility loci in Finns. Here we have fine mapped the region on chromosome 5p in 28 Finnish MS families. Marker D5S416 provided the highest pairwise LOD score, and multipoint and haplotype analyses restrict the critical region to about 5.3 Mb on 5p15 between markers D5S1987 and D5S416. Ascertaining for HLA type and geographical origin indicated that families with and without the HLA DR15 risk haplotype, as well as families within and outside an internal high-risk region, contributed to the linkage to 5p, implying the general significance for this locus in Finnish MS families.

Authors+Show Affiliations

Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16169605

Citation

Riise Stensland, Hilde Monica F., et al. "Fine Mapping of the Multiple Sclerosis Susceptibility Locus On 5p14-p12." Journal of Neuroimmunology, vol. 170, no. 1-2, 2005, pp. 122-33.
Riise Stensland HM, Saarela J, Bronnikov DO, et al. Fine mapping of the multiple sclerosis susceptibility locus on 5p14-p12. J Neuroimmunol. 2005;170(1-2):122-33.
Riise Stensland, H. M., Saarela, J., Bronnikov, D. O., Parkkonen, M., Jokiaho, A. J., Palotie, A., Tienari, P. J., Sumelahti, M. L., Elovaara, I., Koivisto, K., Pirttilä, T., Reunanen, M., Sobel, E., & Peltonen, L. (2005). Fine mapping of the multiple sclerosis susceptibility locus on 5p14-p12. Journal of Neuroimmunology, 170(1-2), 122-33.
Riise Stensland HM, et al. Fine Mapping of the Multiple Sclerosis Susceptibility Locus On 5p14-p12. J Neuroimmunol. 2005 Dec 30;170(1-2):122-33. PubMed PMID: 16169605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fine mapping of the multiple sclerosis susceptibility locus on 5p14-p12. AU - Riise Stensland,Hilde Monica F, AU - Saarela,Janna, AU - Bronnikov,Denis O, AU - Parkkonen,Maija, AU - Jokiaho,Anne J, AU - Palotie,Aarno, AU - Tienari,Pentti J, AU - Sumelahti,Marja-Liisa, AU - Elovaara,Irina, AU - Koivisto,Keijo, AU - Pirttilä,Tuula, AU - Reunanen,Mauri, AU - Sobel,Eric, AU - Peltonen,Leena, Y1 - 2005/09/19/ PY - 2005/05/25/received PY - 2005/08/05/accepted PY - 2005/9/20/pubmed PY - 2006/2/16/medline PY - 2005/9/20/entrez SP - 122 EP - 33 JF - Journal of neuroimmunology JO - J. Neuroimmunol. VL - 170 IS - 1-2 N2 - Linkage analyses have identified four major MS susceptibility loci in Finns. Here we have fine mapped the region on chromosome 5p in 28 Finnish MS families. Marker D5S416 provided the highest pairwise LOD score, and multipoint and haplotype analyses restrict the critical region to about 5.3 Mb on 5p15 between markers D5S1987 and D5S416. Ascertaining for HLA type and geographical origin indicated that families with and without the HLA DR15 risk haplotype, as well as families within and outside an internal high-risk region, contributed to the linkage to 5p, implying the general significance for this locus in Finnish MS families. SN - 0165-5728 UR - https://www.unboundmedicine.com/medline/citation/16169605/Fine_mapping_of_the_multiple_sclerosis_susceptibility_locus_on_5p14_p12_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5728(05)00334-6 DB - PRIME DP - Unbound Medicine ER -