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Fatigue in long-term Hodgkin's Disease survivors: a follow-up study.
J Clin Oncol. 2005 Sep 20; 23(27):6587-95.JC

Abstract

PURPOSE

To describe total fatigue (TF) and chronic fatigue (CF) in 476 long-term Hodgkin's disease survivors (HDSs). The development in CF over time was explored in 280 of the patients who had also been assessed 8 years earlier.

PATIENTS AND METHODS

In 2003, the Fatigue Questionnaire was mailed to 610 successfully treated HDSs at the Norwegian Radium Hospital from 1971 to 1997. Mean TF scores and occurrence of CF were compared with general population (GP) values.

RESULTS

Four hundred seventy-six complete forms (81%) were received (median age, 46 years; 56% males, median follow-up time, 195 months). There was a positive association between age and TF (P < .05), whereas presence of B symptoms at diagnosis and treatment before 1980 were associated with CF. Mean TF scores were elevated in HDSs compared with the GP (mean TF score, 14.6; 95% CI, 14.1 to 15.7 v 12.1; 95% CI, 11.9 to 12.3, respectively; P < .001), as was the proportion of persons with CF (30% v 11%, respectively; odds ratio = 3.6; P < .001). The 70 patients with CF 8 years earlier still reported higher TF at follow-up than the 210 patients without CF at the previous assessment (mean TF score, 17.0; 95% CI, 15.6 to 18.3 v 13.1; 95% CI, 12.9 to 14.1, respectively; P < .001). Significantly more patients with persisting CF had B symptoms at diagnosis compared with patients who had recovered (P = .05). No significant association with treatment modality and intensity was found.

CONCLUSION

Fatigue remains a major complaint in HDSs several years after treatment, but the association between treatment and fatigue still remains unclear. Many HDSs may recover from CF, particularly patients without B symptoms at diagnosis.

Authors+Show Affiliations

Department of Oncology, Ullevål University Hospital HF, KSLB, 0407 Oslo, Norway. m.j.hjermstad@basalmed.uio.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16170166

Citation

Hjermstad, Marianne J., et al. "Fatigue in Long-term Hodgkin's Disease Survivors: a Follow-up Study." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, vol. 23, no. 27, 2005, pp. 6587-95.
Hjermstad MJ, Fosså SD, Oldervoll L, et al. Fatigue in long-term Hodgkin's Disease survivors: a follow-up study. J Clin Oncol. 2005;23(27):6587-95.
Hjermstad, M. J., Fosså, S. D., Oldervoll, L., Holte, H., Jacobsen, A. B., & Loge, J. H. (2005). Fatigue in long-term Hodgkin's Disease survivors: a follow-up study. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 23(27), 6587-95.
Hjermstad MJ, et al. Fatigue in Long-term Hodgkin's Disease Survivors: a Follow-up Study. J Clin Oncol. 2005 Sep 20;23(27):6587-95. PubMed PMID: 16170166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatigue in long-term Hodgkin's Disease survivors: a follow-up study. AU - Hjermstad,Marianne J, AU - Fosså,Sophie D, AU - Oldervoll,Line, AU - Holte,Harald, AU - Jacobsen,Anne B, AU - Loge,Jon H, PY - 2005/9/20/pubmed PY - 2005/10/28/medline PY - 2005/9/20/entrez SP - 6587 EP - 95 JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology JO - J Clin Oncol VL - 23 IS - 27 N2 - PURPOSE: To describe total fatigue (TF) and chronic fatigue (CF) in 476 long-term Hodgkin's disease survivors (HDSs). The development in CF over time was explored in 280 of the patients who had also been assessed 8 years earlier. PATIENTS AND METHODS: In 2003, the Fatigue Questionnaire was mailed to 610 successfully treated HDSs at the Norwegian Radium Hospital from 1971 to 1997. Mean TF scores and occurrence of CF were compared with general population (GP) values. RESULTS: Four hundred seventy-six complete forms (81%) were received (median age, 46 years; 56% males, median follow-up time, 195 months). There was a positive association between age and TF (P < .05), whereas presence of B symptoms at diagnosis and treatment before 1980 were associated with CF. Mean TF scores were elevated in HDSs compared with the GP (mean TF score, 14.6; 95% CI, 14.1 to 15.7 v 12.1; 95% CI, 11.9 to 12.3, respectively; P < .001), as was the proportion of persons with CF (30% v 11%, respectively; odds ratio = 3.6; P < .001). The 70 patients with CF 8 years earlier still reported higher TF at follow-up than the 210 patients without CF at the previous assessment (mean TF score, 17.0; 95% CI, 15.6 to 18.3 v 13.1; 95% CI, 12.9 to 14.1, respectively; P < .001). Significantly more patients with persisting CF had B symptoms at diagnosis compared with patients who had recovered (P = .05). No significant association with treatment modality and intensity was found. CONCLUSION: Fatigue remains a major complaint in HDSs several years after treatment, but the association between treatment and fatigue still remains unclear. Many HDSs may recover from CF, particularly patients without B symptoms at diagnosis. SN - 0732-183X UR - https://www.unboundmedicine.com/medline/citation/16170166/Fatigue_in_long_term_Hodgkin's_Disease_survivors:_a_follow_up_study_ L2 - https://ascopubs.org/doi/10.1200/JCO.2005.09.936?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -