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Significance of serum trace element status in patients with rheumatic heart disease: a prospective study.
Biol Trace Elem Res. 2005 Oct; 107(1):1-10.BT

Abstract

It is known that certain trace elements can affect various heart diseases. In this study, we aimed to evaluate the changes in concentrations of certain serum trace elements in patients with chronic rheumatic heart disease (RHD). Serum analysis of selenium (Se), zinc (Zn), and copper (Cu) trace elements was assayed by atomic absorption spectrophotometry. RHD patients had significantly lower serum concentrations of Se and Zn than control subjects (p < 0.05 and p < 0.001, respectively). However, the serum Cu concentration was significantly higher in RHD patients than in controls (1.93 +/- 0.59 microg/L vs 1.06 +/- 0.29 microg/L; p < 0.001). Similarly, the Cu/Zn ratio in RHD patients was higher than in control subjects (4.70 +/- 0.92 vs 1.68 +/- 0.45; p < 0.001). Additionally, no significant correlation was found among these trace element concentrations and the functional capacity classes (p > 0.05). RHD patients had decreased serum Se and Zn element concentrations and increased serum Cu element concentration. We suggest that Se and Zn deficiency might be contributory factors in the development of rheumatic heart disease, and a high Cu concentration and a high Cu/Zn ratio might reflect an ongoing inflammatory process in this disease.

Authors+Show Affiliations

Department of Cardiology, Inonu University, Faculty of Medicine, Turgut Ozal Medical Center, Malatya, Turkey. mferidunkosar@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16170217

Citation

Kosar, Feridun, et al. "Significance of Serum Trace Element Status in Patients With Rheumatic Heart Disease: a Prospective Study." Biological Trace Element Research, vol. 107, no. 1, 2005, pp. 1-10.
Kosar F, Sahin I, Acikgöz N, et al. Significance of serum trace element status in patients with rheumatic heart disease: a prospective study. Biol Trace Elem Res. 2005;107(1):1-10.
Kosar, F., Sahin, I., Acikgöz, N., Aksoy, Y., Kucukbay, Z., & Cehreli, S. (2005). Significance of serum trace element status in patients with rheumatic heart disease: a prospective study. Biological Trace Element Research, 107(1), 1-10.
Kosar F, et al. Significance of Serum Trace Element Status in Patients With Rheumatic Heart Disease: a Prospective Study. Biol Trace Elem Res. 2005;107(1):1-10. PubMed PMID: 16170217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Significance of serum trace element status in patients with rheumatic heart disease: a prospective study. AU - Kosar,Feridun, AU - Sahin,Ibrahim, AU - Acikgöz,Nusret, AU - Aksoy,Yuksek, AU - Kucukbay,Zehra, AU - Cehreli,Sengul, PY - 2004/10/18/received PY - 2004/11/17/revised PY - 2004/12/11/accepted PY - 2005/9/20/pubmed PY - 2005/12/15/medline PY - 2005/9/20/entrez SP - 1 EP - 10 JF - Biological trace element research JO - Biol Trace Elem Res VL - 107 IS - 1 N2 - It is known that certain trace elements can affect various heart diseases. In this study, we aimed to evaluate the changes in concentrations of certain serum trace elements in patients with chronic rheumatic heart disease (RHD). Serum analysis of selenium (Se), zinc (Zn), and copper (Cu) trace elements was assayed by atomic absorption spectrophotometry. RHD patients had significantly lower serum concentrations of Se and Zn than control subjects (p < 0.05 and p < 0.001, respectively). However, the serum Cu concentration was significantly higher in RHD patients than in controls (1.93 +/- 0.59 microg/L vs 1.06 +/- 0.29 microg/L; p < 0.001). Similarly, the Cu/Zn ratio in RHD patients was higher than in control subjects (4.70 +/- 0.92 vs 1.68 +/- 0.45; p < 0.001). Additionally, no significant correlation was found among these trace element concentrations and the functional capacity classes (p > 0.05). RHD patients had decreased serum Se and Zn element concentrations and increased serum Cu element concentration. We suggest that Se and Zn deficiency might be contributory factors in the development of rheumatic heart disease, and a high Cu concentration and a high Cu/Zn ratio might reflect an ongoing inflammatory process in this disease. SN - 0163-4984 UR - https://www.unboundmedicine.com/medline/citation/16170217/Significance_of_serum_trace_element_status_in_patients_with_rheumatic_heart_disease:_a_prospective_study_ L2 - https://dx.doi.org/10.1385/BTER:107:1:001 DB - PRIME DP - Unbound Medicine ER -