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Do adiponectin, TNFalpha, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy.
Diabetes Metab Res Rev. 2006 Mar-Apr; 22(2):131-8.DM

Abstract

BACKGROUND

The role of adiponectin, tumour necrosis factor alpha (TNFalpha), leptin and C-reactive protein in the insulin resistance of pregnancy is not clear. We measured their levels in women with gestational diabetes (GDM) and in controls, during and after pregnancy, and related them to insulin secretion and action.

METHODS

Nineteen women with GDM and 19 BMI-matched healthy pregnant women underwent intravenous glucose tolerance tests in the third trimester of pregnancy and 4 months postpartum to determine insulin sensitivity (SI) and insulin secretion. Adiponectin, TNFalpha, leptin and high sensitivity CRP (hsCRP) were measured in fasted blood.

RESULTS

Of the circulating factors, only leptin (r = -0.41, p = 0.01) correlated with SI in pregnancy. Leptin and hsCRP levels were elevated in pregnancy compared to postpartum (leptin (mean +/- SEM): 27.8 +/- 2.4 vs 19.3 +/- 2.1 ng/mL, p < 0.001; hsCRP: 5.2 +/- 0.7 vs 3.2 +/- 0.6 mg/L, p < 0.001). Adiponectin levels did not change from pregnancy to postpartum, despite a marked increase in SI. All four factors correlated with SI postpartum (adiponectin: r = 0.38, p = 0.01; TNFalpha: r = -0.48, p = 0.002; Leptin: r = -0.61, p = 0.001; hsCRP: r = -0.48, p = 0.002). TNFalpha correlated inversely with insulin secretion in pregnancy (r = -0.35, p = 0.03) and was significantly higher in the GDM group (2.62 +/- 0.3 vs 1.88 +/- 0.3 pg/mL, p = 0.01) in pregnancy.

CONCLUSION

In our study, the influence of adiponectin, TNFalpha and hsCRP upon SI is overwhelmed by other factors in pregnancy. While leptin and SI correlated in pregnancy, it is unclear whether this represents cause or effect. Finally, TNFalpha may exert an inhibitory effect on insulin secretion in GDM, contributing to the associated hyperglycaemia.

Authors+Show Affiliations

Department of Endocrinology, St Vincents Hospital, Victoria, Australia. jane.ford@svhm.org.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16170833

Citation

McLachlan, Kylie A., et al. "Do Adiponectin, TNFalpha, Leptin and CRP Relate to Insulin Resistance in Pregnancy? Studies in Women With and Without Gestational Diabetes, During and After Pregnancy." Diabetes/metabolism Research and Reviews, vol. 22, no. 2, 2006, pp. 131-8.
McLachlan KA, O'Neal D, Jenkins A, et al. Do adiponectin, TNFalpha, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy. Diabetes Metab Res Rev. 2006;22(2):131-8.
McLachlan, K. A., O'Neal, D., Jenkins, A., & Alford, F. P. (2006). Do adiponectin, TNFalpha, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy. Diabetes/metabolism Research and Reviews, 22(2), 131-8.
McLachlan KA, et al. Do Adiponectin, TNFalpha, Leptin and CRP Relate to Insulin Resistance in Pregnancy? Studies in Women With and Without Gestational Diabetes, During and After Pregnancy. Diabetes Metab Res Rev. 2006 Mar-Apr;22(2):131-8. PubMed PMID: 16170833.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Do adiponectin, TNFalpha, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy. AU - McLachlan,Kylie A, AU - O'Neal,David, AU - Jenkins,Alicia, AU - Alford,Frank P, PY - 2005/9/20/pubmed PY - 2006/5/4/medline PY - 2005/9/20/entrez SP - 131 EP - 8 JF - Diabetes/metabolism research and reviews JO - Diabetes Metab. Res. Rev. VL - 22 IS - 2 N2 - BACKGROUND: The role of adiponectin, tumour necrosis factor alpha (TNFalpha), leptin and C-reactive protein in the insulin resistance of pregnancy is not clear. We measured their levels in women with gestational diabetes (GDM) and in controls, during and after pregnancy, and related them to insulin secretion and action. METHODS: Nineteen women with GDM and 19 BMI-matched healthy pregnant women underwent intravenous glucose tolerance tests in the third trimester of pregnancy and 4 months postpartum to determine insulin sensitivity (SI) and insulin secretion. Adiponectin, TNFalpha, leptin and high sensitivity CRP (hsCRP) were measured in fasted blood. RESULTS: Of the circulating factors, only leptin (r = -0.41, p = 0.01) correlated with SI in pregnancy. Leptin and hsCRP levels were elevated in pregnancy compared to postpartum (leptin (mean +/- SEM): 27.8 +/- 2.4 vs 19.3 +/- 2.1 ng/mL, p < 0.001; hsCRP: 5.2 +/- 0.7 vs 3.2 +/- 0.6 mg/L, p < 0.001). Adiponectin levels did not change from pregnancy to postpartum, despite a marked increase in SI. All four factors correlated with SI postpartum (adiponectin: r = 0.38, p = 0.01; TNFalpha: r = -0.48, p = 0.002; Leptin: r = -0.61, p = 0.001; hsCRP: r = -0.48, p = 0.002). TNFalpha correlated inversely with insulin secretion in pregnancy (r = -0.35, p = 0.03) and was significantly higher in the GDM group (2.62 +/- 0.3 vs 1.88 +/- 0.3 pg/mL, p = 0.01) in pregnancy. CONCLUSION: In our study, the influence of adiponectin, TNFalpha and hsCRP upon SI is overwhelmed by other factors in pregnancy. While leptin and SI correlated in pregnancy, it is unclear whether this represents cause or effect. Finally, TNFalpha may exert an inhibitory effect on insulin secretion in GDM, contributing to the associated hyperglycaemia. SN - 1520-7552 UR - https://www.unboundmedicine.com/medline/citation/16170833/Do_adiponectin_TNFalpha_leptin_and_CRP_relate_to_insulin_resistance_in_pregnancy_Studies_in_women_with_and_without_gestational_diabetes_during_and_after_pregnancy_ L2 - https://doi.org/10.1002/dmrr.591 DB - PRIME DP - Unbound Medicine ER -