Tags

Type your tag names separated by a space and hit enter

Putranjivain A from Euphorbia jolkini inhibits proliferation of human breast adenocarcinoma MCF-7 cells via blocking cell cycle progression and inducing apoptosis.
Toxicol Appl Pharmacol. 2006 May 15; 213(1):37-45.TA

Abstract

Putranjivain A, isolated from the whole plant of Euphorbia jolkini Bioss (Euphorbiaceae), was investigated for its antiproliferative activity in human breast adenocarcinoma MCF-7 cells. The results showed that putranjivain A inhibited the proliferation of MCF-7 by blocking cell cycle progression in the G0/G1 phase and inducing apoptosis. Enzyme-linked immunosorbent assay showed that putranjivain A increased the expression of p21/WAF1 concomitantly as MCF-7 cell underwent G0/G1 arrest. An enhancement in Fas/APO-1 and its two forms of ligands, membrane-bound Fas ligand (mFasL) and soluble Fas ligand (sFasL), might be responsible for the apoptotic effect induced by putranjivain A. Our study reports here for the first time that the induction of p21/WAF1 and the activity of Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of putranjivain A in MCF-7 cells.

Authors+Show Affiliations

Kuo PL
Department of Biotechnology, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan.
Cho CY
No affiliation info available
Hsu YL
No affiliation info available
Lin TC
No affiliation info available
Lin CC
No affiliation info available

MeSH

AdenocarcinomaAntineoplastic Agents, PhytogenicApoptosisBreast NeoplasmsCell CycleCell Line, TumorCell ProliferationCyclin-Dependent Kinase Inhibitor p21EuphorbiaFas Ligand ProteinFemaleGallic AcidGlucosidesHumansMembrane GlycoproteinsTumor Necrosis FactorsTumor Suppressor Protein p53fas Receptor

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16171837

Citation

Kuo, Po-Lin, et al. "Putranjivain a From Euphorbia Jolkini Inhibits Proliferation of Human Breast Adenocarcinoma MCF-7 Cells Via Blocking Cell Cycle Progression and Inducing Apoptosis." Toxicology and Applied Pharmacology, vol. 213, no. 1, 2006, pp. 37-45.
Kuo PL, Cho CY, Hsu YL, et al. Putranjivain A from Euphorbia jolkini inhibits proliferation of human breast adenocarcinoma MCF-7 cells via blocking cell cycle progression and inducing apoptosis. Toxicol Appl Pharmacol. 2006;213(1):37-45.
Kuo, P. L., Cho, C. Y., Hsu, Y. L., Lin, T. C., & Lin, C. C. (2006). Putranjivain A from Euphorbia jolkini inhibits proliferation of human breast adenocarcinoma MCF-7 cells via blocking cell cycle progression and inducing apoptosis. Toxicology and Applied Pharmacology, 213(1), 37-45.
Kuo PL, et al. Putranjivain a From Euphorbia Jolkini Inhibits Proliferation of Human Breast Adenocarcinoma MCF-7 Cells Via Blocking Cell Cycle Progression and Inducing Apoptosis. Toxicol Appl Pharmacol. 2006 May 15;213(1):37-45. PubMed PMID: 16171837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Putranjivain A from Euphorbia jolkini inhibits proliferation of human breast adenocarcinoma MCF-7 cells via blocking cell cycle progression and inducing apoptosis. AU - Kuo,Po-Lin, AU - Cho,Chien-Yu, AU - Hsu,Ya-Ling, AU - Lin,Ta-Chen, AU - Lin,Chun-Ching, Y1 - 2005/09/19/ PY - 2005/05/27/received PY - 2005/08/23/revised PY - 2005/08/23/accepted PY - 2005/9/21/pubmed PY - 2006/6/21/medline PY - 2005/9/21/entrez SP - 37 EP - 45 JF - Toxicology and applied pharmacology JO - Toxicol Appl Pharmacol VL - 213 IS - 1 N2 - Putranjivain A, isolated from the whole plant of Euphorbia jolkini Bioss (Euphorbiaceae), was investigated for its antiproliferative activity in human breast adenocarcinoma MCF-7 cells. The results showed that putranjivain A inhibited the proliferation of MCF-7 by blocking cell cycle progression in the G0/G1 phase and inducing apoptosis. Enzyme-linked immunosorbent assay showed that putranjivain A increased the expression of p21/WAF1 concomitantly as MCF-7 cell underwent G0/G1 arrest. An enhancement in Fas/APO-1 and its two forms of ligands, membrane-bound Fas ligand (mFasL) and soluble Fas ligand (sFasL), might be responsible for the apoptotic effect induced by putranjivain A. Our study reports here for the first time that the induction of p21/WAF1 and the activity of Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of putranjivain A in MCF-7 cells. SN - 0041-008X UR - https://www.unboundmedicine.com/medline/citation/16171837/Putranjivain_A_from_Euphorbia_jolkini_inhibits_proliferation_of_human_breast_adenocarcinoma_MCF_7_cells_via_blocking_cell_cycle_progression_and_inducing_apoptosis_ DB - PRIME DP - Unbound Medicine ER -