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Sugar-sweetened soft drink consumption and risk of pancreatic cancer in two prospective cohorts.
Cancer Epidemiol Biomarkers Prev. 2005 Sep; 14(9):2098-105.CE

Abstract

BACKGROUND

A history of diabetes mellitus and a diet high in glycemic load are both potential risk factors for pancreatic cancer. Sugar-sweetened soft drinks are a prevalent source of readily absorbable sugars and have been associated with an increased risk of obesity and diabetes. We investigated whether higher consumption of sugar-sweetened soft drinks increases the risk of pancreatic cancer.

METHODS

We examined the relation between consumption of sugar-sweetened soft drinks and the development of pancreatic cancer in the Nurses' Health Study and the Health Professionals Follow-up Study. Among 88,794 women and 49,364 men without cancer at baseline, we documented 379 cases of pancreatic cancer during up to 20 years of follow-up. Soft drink consumption was first assessed at baseline (1980 for the women, 1986 for the men) and updated periodically thereafter.

RESULTS

Compared with participants who largely abstained from sugar-sweetened soft drinks, those who consumed more than three sugar-sweetened soft drinks weekly experienced overall a multivariate relative risk (RR) of pancreatic cancer of 1.13 [95% confidence interval (95% CI), 0.81-1.58; P for trend = 0.47]. Women in the highest category of sugar-sweetened soft drink intake did experience a significant increase in risk (RR, 1.57; 95% CI, 1.02-2.41; P for trend = 0.05), whereas there was no association between sweetened soft drink intake and pancreatic cancer among men. Among women, the risk associated with higher sugar-sweetened soft drink was limited to those with elevated body mass index (>25 kg/m(2); RR, 1.89; 95% CI, 0.96-3.72) or with low physical activity (RR, 2.02; 95% CI, 1.06-3.85). In contrast, consumption of diet soft drinks was not associated with an elevated pancreatic cancer risk in either cohort.

CONCLUSION

Although soft drink consumption did not influence pancreatic cancer risk among men, consumption of sugar-sweetened soft drinks may be associated with a modest but significant increase in risk among women who have an underlying degree of insulin resistance.

Authors+Show Affiliations

Schernhammer ES
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. eva.schernhammer@channing.harvard.edu
Hu FB
No affiliation info available
Giovannucci E
No affiliation info available
Michaud DS
No affiliation info available
Colditz GA
No affiliation info available
Stampfer MJ
No affiliation info available
Fuchs CS
No affiliation info available

MeSH

AdultBeveragesDietary SucroseFemaleHumansLife StyleMaleMiddle AgedPancreatic NeoplasmsPhysical FitnessProspective StudiesRisk FactorsSex Factors

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16172216

Citation

Schernhammer, Eva S., et al. "Sugar-sweetened Soft Drink Consumption and Risk of Pancreatic Cancer in Two Prospective Cohorts." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 14, no. 9, 2005, pp. 2098-105.
Schernhammer ES, Hu FB, Giovannucci E, et al. Sugar-sweetened soft drink consumption and risk of pancreatic cancer in two prospective cohorts. Cancer Epidemiol Biomarkers Prev. 2005;14(9):2098-105.
Schernhammer, E. S., Hu, F. B., Giovannucci, E., Michaud, D. S., Colditz, G. A., Stampfer, M. J., & Fuchs, C. S. (2005). Sugar-sweetened soft drink consumption and risk of pancreatic cancer in two prospective cohorts. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 14(9), 2098-105.
Schernhammer ES, et al. Sugar-sweetened Soft Drink Consumption and Risk of Pancreatic Cancer in Two Prospective Cohorts. Cancer Epidemiol Biomarkers Prev. 2005;14(9):2098-105. PubMed PMID: 16172216.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sugar-sweetened soft drink consumption and risk of pancreatic cancer in two prospective cohorts. AU - Schernhammer,Eva S, AU - Hu,Frank B, AU - Giovannucci,Ed, AU - Michaud,Dominique S, AU - Colditz,Graham A, AU - Stampfer,Meir J, AU - Fuchs,Charles S, PY - 2005/9/21/pubmed PY - 2005/12/13/medline PY - 2005/9/21/entrez SP - 2098 EP - 105 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 14 IS - 9 N2 - BACKGROUND: A history of diabetes mellitus and a diet high in glycemic load are both potential risk factors for pancreatic cancer. Sugar-sweetened soft drinks are a prevalent source of readily absorbable sugars and have been associated with an increased risk of obesity and diabetes. We investigated whether higher consumption of sugar-sweetened soft drinks increases the risk of pancreatic cancer. METHODS: We examined the relation between consumption of sugar-sweetened soft drinks and the development of pancreatic cancer in the Nurses' Health Study and the Health Professionals Follow-up Study. Among 88,794 women and 49,364 men without cancer at baseline, we documented 379 cases of pancreatic cancer during up to 20 years of follow-up. Soft drink consumption was first assessed at baseline (1980 for the women, 1986 for the men) and updated periodically thereafter. RESULTS: Compared with participants who largely abstained from sugar-sweetened soft drinks, those who consumed more than three sugar-sweetened soft drinks weekly experienced overall a multivariate relative risk (RR) of pancreatic cancer of 1.13 [95% confidence interval (95% CI), 0.81-1.58; P for trend = 0.47]. Women in the highest category of sugar-sweetened soft drink intake did experience a significant increase in risk (RR, 1.57; 95% CI, 1.02-2.41; P for trend = 0.05), whereas there was no association between sweetened soft drink intake and pancreatic cancer among men. Among women, the risk associated with higher sugar-sweetened soft drink was limited to those with elevated body mass index (>25 kg/m(2); RR, 1.89; 95% CI, 0.96-3.72) or with low physical activity (RR, 2.02; 95% CI, 1.06-3.85). In contrast, consumption of diet soft drinks was not associated with an elevated pancreatic cancer risk in either cohort. CONCLUSION: Although soft drink consumption did not influence pancreatic cancer risk among men, consumption of sugar-sweetened soft drinks may be associated with a modest but significant increase in risk among women who have an underlying degree of insulin resistance. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/16172216/Sugar_sweetened_soft_drink_consumption_and_risk_of_pancreatic_cancer_in_two_prospective_cohorts_ DB - PRIME DP - Unbound Medicine ER -