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Relative and absolute risks of cigarette smoking on major histologic types of lung cancer in Korean men.
Cancer Epidemiol Biomarkers Prev 2005; 14(9):2125-30CE

Abstract

OBJECTIVES

Most prospective cohort studies of lung cancer focus on the relative risk rather than the absolute risk of smoking.

METHODS

This prospective study included 437,976 Korean men (cohort for the National Health Insurance Cooperation Study), > or = 40 years old, who were free of cancer and smoking-related chronic disease at the time of enrollment. Based on new incidence cases, relative risk and excess risk, and their 95% confidence intervals (95% CI), were estimated with the standard Poisson regression model after adjustment for age or other demographic factors and other confounders.

RESULTS

During the 6-year follow-up period of 3,142,451 person-years, 1,357 new lung cancer cases were identified. Based on the multivariate-adjusted relative risk for current smokers, the strongest association with smoking was shown for small-cell lung cancer (relative risk, 21.7; 95% CI, 8.0-58.5) followed by squamous cell carcinoma (relative risk, 11.7; 95% CI, 7.1-19.4) and then adenocarcinoma (relative risk, 2.1; 95% CI, 1.6-2.7). In current smokers with > or = 40 pack-years of exposure, excess risk was highest for squamous cell carcinoma (excess risk, 33.8; 95% CI, 10.2-109.8) followed by adenocarcinoma (excess risk, 26.7; 95% CI, 10.3-64.4), and then small-cell carcinoma (excess risk, 16.3; 95% CI, 1.8-144.3).

CONCLUSIONS

In Korean men, cigarette smoking was as important a risk factor for adenocarcinoma as it was for squamous cell and small-cell lung cancer.

Authors+Show Affiliations

Research Institute and Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, South Korea. lawyun@ncc.re.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16172220

Citation

Yun, Young Ho, et al. "Relative and Absolute Risks of Cigarette Smoking On Major Histologic Types of Lung Cancer in Korean Men." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 14, no. 9, 2005, pp. 2125-30.
Yun YH, Lim MK, Jung KW, et al. Relative and absolute risks of cigarette smoking on major histologic types of lung cancer in Korean men. Cancer Epidemiol Biomarkers Prev. 2005;14(9):2125-30.
Yun, Y. H., Lim, M. K., Jung, K. W., Bae, J. M., Park, S. M., Shin, S. A., ... Park, J. G. (2005). Relative and absolute risks of cigarette smoking on major histologic types of lung cancer in Korean men. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 14(9), pp. 2125-30.
Yun YH, et al. Relative and Absolute Risks of Cigarette Smoking On Major Histologic Types of Lung Cancer in Korean Men. Cancer Epidemiol Biomarkers Prev. 2005;14(9):2125-30. PubMed PMID: 16172220.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relative and absolute risks of cigarette smoking on major histologic types of lung cancer in Korean men. AU - Yun,Young Ho, AU - Lim,Min Kyung, AU - Jung,Kyu Won, AU - Bae,Jong-Myon, AU - Park,Sang Min, AU - Shin,Soon Ae, AU - Lee,Jin Soo, AU - Park,Jae-Gahb, PY - 2005/9/21/pubmed PY - 2005/12/13/medline PY - 2005/9/21/entrez SP - 2125 EP - 30 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 14 IS - 9 N2 - OBJECTIVES: Most prospective cohort studies of lung cancer focus on the relative risk rather than the absolute risk of smoking. METHODS: This prospective study included 437,976 Korean men (cohort for the National Health Insurance Cooperation Study), > or = 40 years old, who were free of cancer and smoking-related chronic disease at the time of enrollment. Based on new incidence cases, relative risk and excess risk, and their 95% confidence intervals (95% CI), were estimated with the standard Poisson regression model after adjustment for age or other demographic factors and other confounders. RESULTS: During the 6-year follow-up period of 3,142,451 person-years, 1,357 new lung cancer cases were identified. Based on the multivariate-adjusted relative risk for current smokers, the strongest association with smoking was shown for small-cell lung cancer (relative risk, 21.7; 95% CI, 8.0-58.5) followed by squamous cell carcinoma (relative risk, 11.7; 95% CI, 7.1-19.4) and then adenocarcinoma (relative risk, 2.1; 95% CI, 1.6-2.7). In current smokers with > or = 40 pack-years of exposure, excess risk was highest for squamous cell carcinoma (excess risk, 33.8; 95% CI, 10.2-109.8) followed by adenocarcinoma (excess risk, 26.7; 95% CI, 10.3-64.4), and then small-cell carcinoma (excess risk, 16.3; 95% CI, 1.8-144.3). CONCLUSIONS: In Korean men, cigarette smoking was as important a risk factor for adenocarcinoma as it was for squamous cell and small-cell lung cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/16172220/Relative_and_absolute_risks_of_cigarette_smoking_on_major_histologic_types_of_lung_cancer_in_Korean_men_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=16172220 DB - PRIME DP - Unbound Medicine ER -