Citation
Anderson, Kristin E., et al. "Dietary Intake of Heterocyclic Amines and Benzo(a)pyrene: Associations With Pancreatic Cancer." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 14, no. 9, 2005, pp. 2261-5.
Anderson KE, Kadlubar FF, Kulldorff M, et al. Dietary intake of heterocyclic amines and benzo(a)pyrene: associations with pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2005;14(9):2261-5.
Anderson, K. E., Kadlubar, F. F., Kulldorff, M., Harnack, L., Gross, M., Lang, N. P., Barber, C., Rothman, N., & Sinha, R. (2005). Dietary intake of heterocyclic amines and benzo(a)pyrene: associations with pancreatic cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 14(9), 2261-5.
Anderson KE, et al. Dietary Intake of Heterocyclic Amines and Benzo(a)pyrene: Associations With Pancreatic Cancer. Cancer Epidemiol Biomarkers Prev. 2005;14(9):2261-5. PubMed PMID: 16172241.
TY - JOUR
T1 - Dietary intake of heterocyclic amines and benzo(a)pyrene: associations with pancreatic cancer.
AU - Anderson,Kristin E,
AU - Kadlubar,Fred F,
AU - Kulldorff,Martin,
AU - Harnack,Lisa,
AU - Gross,Myron,
AU - Lang,Nicholas P,
AU - Barber,Cheryl,
AU - Rothman,Nat,
AU - Sinha,Rashmi,
PY - 2005/9/21/pubmed
PY - 2005/12/13/medline
PY - 2005/9/21/entrez
SP - 2261
EP - 5
JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
JO - Cancer Epidemiol Biomarkers Prev
VL - 14
IS - 9
N2 - OBJECTIVE: Heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons, formed in temperature- and time-dependent manners during the cooking of meat, are mutagens and carcinogens. We sought to assess the association between dietary intake of HCA and benzo(a)pyrene [B(a)P] and exocrine pancreatic cancer in a population-based case-control study. METHODS: Subjects (193 cases and 674 controls) provided information on their usual meat intake and preparation method, e.g., stewed, fried, or grilled/barbecued, etc. Meat doneness preferences were measured using photographs that showed internal doneness and external brownness. We used a meat-derived HCA, B(a)P, and mutagen database with a questionnaire to estimate intake of PhIP, DiMeIQx, MeIQx, B(a)P, and mutagenic activity (revertants/g of daily meat intake). Data were analyzed with unconditional logistic regression. RESULTS: In analyses adjusted for age, sex, smoking, education, race, and diabetes, the odds ratio and 95% confidence interval for the highest compared with the lowest quintile were as follows: PhIP, 1.8 (1.0-3.1); DiMeIQx, 2.0 (1.2-3.5); MeIQx, 1.5 (0.9-2.7); B(a)P, 2.2 (1.2-4.0); and mutagenic activity, 2.4 (1.3-4.3). CONCLUSIONS: HCAs and B(a)P from well-done barbecued and pan-fried meats may be associated with increased risk for pancreatic cancer.
SN - 1055-9965
UR - https://www.unboundmedicine.com/medline/citation/16172241/Dietary_intake_of_heterocyclic_amines_and_benzo_a_pyrene:_associations_with_pancreatic_cancer_
L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=16172241
DB - PRIME
DP - Unbound Medicine
ER -