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Dietary intake of heterocyclic amines and benzo(a)pyrene: associations with pancreatic cancer.
Cancer Epidemiol Biomarkers Prev 2005; 14(9):2261-5CE

Abstract

OBJECTIVE

Heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons, formed in temperature- and time-dependent manners during the cooking of meat, are mutagens and carcinogens. We sought to assess the association between dietary intake of HCA and benzo(a)pyrene [B(a)P] and exocrine pancreatic cancer in a population-based case-control study.

METHODS

Subjects (193 cases and 674 controls) provided information on their usual meat intake and preparation method, e.g., stewed, fried, or grilled/barbecued, etc. Meat doneness preferences were measured using photographs that showed internal doneness and external brownness. We used a meat-derived HCA, B(a)P, and mutagen database with a questionnaire to estimate intake of PhIP, DiMeIQx, MeIQx, B(a)P, and mutagenic activity (revertants/g of daily meat intake). Data were analyzed with unconditional logistic regression.

RESULTS

In analyses adjusted for age, sex, smoking, education, race, and diabetes, the odds ratio and 95% confidence interval for the highest compared with the lowest quintile were as follows: PhIP, 1.8 (1.0-3.1); DiMeIQx, 2.0 (1.2-3.5); MeIQx, 1.5 (0.9-2.7); B(a)P, 2.2 (1.2-4.0); and mutagenic activity, 2.4 (1.3-4.3).

CONCLUSIONS

HCAs and B(a)P from well-done barbecued and pan-fried meats may be associated with increased risk for pancreatic cancer.

Links

  • Publisher Full Text

    • Authors+Show Affiliations

    Anderson KE
    School of Public Health, University of Minnesota, Minneapolis, 55454, USA. anderson_k@epi.umn.edu
    Kadlubar FF
    No affiliation info available
    Kulldorff M
    No affiliation info available
    Harnack L
    No affiliation info available
    Gross M
    No affiliation info available
    Lang NP
    No affiliation info available
    Barber C
    No affiliation info available
    Rothman N
    No affiliation info available
    Sinha R
    No affiliation info available

    MeSH

    AgedBenzo(a)pyreneBiogenic AminesCase-Control StudiesCookingDietFemaleHeterocyclic CompoundsHumansMaleMeatMiddle AgedOdds RatioPancreatic NeoplasmsRisk Factors

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    16172241

    Citation

    Anderson, Kristin E., et al. "Dietary Intake of Heterocyclic Amines and Benzo(a)pyrene: Associations With Pancreatic Cancer." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 14, no. 9, 2005, pp. 2261-5.
    Anderson KE, Kadlubar FF, Kulldorff M, et al. Dietary intake of heterocyclic amines and benzo(a)pyrene: associations with pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2005;14(9):2261-5.
    Anderson, K. E., Kadlubar, F. F., Kulldorff, M., Harnack, L., Gross, M., Lang, N. P., ... Sinha, R. (2005). Dietary intake of heterocyclic amines and benzo(a)pyrene: associations with pancreatic cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 14(9), pp. 2261-5.
    Anderson KE, et al. Dietary Intake of Heterocyclic Amines and Benzo(a)pyrene: Associations With Pancreatic Cancer. Cancer Epidemiol Biomarkers Prev. 2005;14(9):2261-5. PubMed PMID: 16172241.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary intake of heterocyclic amines and benzo(a)pyrene: associations with pancreatic cancer. AU - Anderson,Kristin E, AU - Kadlubar,Fred F, AU - Kulldorff,Martin, AU - Harnack,Lisa, AU - Gross,Myron, AU - Lang,Nicholas P, AU - Barber,Cheryl, AU - Rothman,Nat, AU - Sinha,Rashmi, PY - 2005/9/21/pubmed PY - 2005/12/13/medline PY - 2005/9/21/entrez SP - 2261 EP - 5 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 14 IS - 9 N2 - OBJECTIVE: Heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons, formed in temperature- and time-dependent manners during the cooking of meat, are mutagens and carcinogens. We sought to assess the association between dietary intake of HCA and benzo(a)pyrene [B(a)P] and exocrine pancreatic cancer in a population-based case-control study. METHODS: Subjects (193 cases and 674 controls) provided information on their usual meat intake and preparation method, e.g., stewed, fried, or grilled/barbecued, etc. Meat doneness preferences were measured using photographs that showed internal doneness and external brownness. We used a meat-derived HCA, B(a)P, and mutagen database with a questionnaire to estimate intake of PhIP, DiMeIQx, MeIQx, B(a)P, and mutagenic activity (revertants/g of daily meat intake). Data were analyzed with unconditional logistic regression. RESULTS: In analyses adjusted for age, sex, smoking, education, race, and diabetes, the odds ratio and 95% confidence interval for the highest compared with the lowest quintile were as follows: PhIP, 1.8 (1.0-3.1); DiMeIQx, 2.0 (1.2-3.5); MeIQx, 1.5 (0.9-2.7); B(a)P, 2.2 (1.2-4.0); and mutagenic activity, 2.4 (1.3-4.3). CONCLUSIONS: HCAs and B(a)P from well-done barbecued and pan-fried meats may be associated with increased risk for pancreatic cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/16172241/Dietary_intake_of_heterocyclic_amines_and_benzo_a_pyrene:_associations_with_pancreatic_cancer_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=16172241 DB - PRIME DP - Unbound Medicine ER -