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Dietary intake of heterocyclic amines and benzo(a)pyrene: associations with pancreatic cancer.

Abstract

OBJECTIVE

Heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons, formed in temperature- and time-dependent manners during the cooking of meat, are mutagens and carcinogens. We sought to assess the association between dietary intake of HCA and benzo(a)pyrene [B(a)P] and exocrine pancreatic cancer in a population-based case-control study.

METHODS

Subjects (193 cases and 674 controls) provided information on their usual meat intake and preparation method, e.g., stewed, fried, or grilled/barbecued, etc. Meat doneness preferences were measured using photographs that showed internal doneness and external brownness. We used a meat-derived HCA, B(a)P, and mutagen database with a questionnaire to estimate intake of PhIP, DiMeIQx, MeIQx, B(a)P, and mutagenic activity (revertants/g of daily meat intake). Data were analyzed with unconditional logistic regression.

RESULTS

In analyses adjusted for age, sex, smoking, education, race, and diabetes, the odds ratio and 95% confidence interval for the highest compared with the lowest quintile were as follows: PhIP, 1.8 (1.0-3.1); DiMeIQx, 2.0 (1.2-3.5); MeIQx, 1.5 (0.9-2.7); B(a)P, 2.2 (1.2-4.0); and mutagenic activity, 2.4 (1.3-4.3).

CONCLUSIONS

HCAs and B(a)P from well-done barbecued and pan-fried meats may be associated with increased risk for pancreatic cancer.

Authors+Show Affiliations

School of Public Health, University of Minnesota, Minneapolis, 55454, USA. anderson_k@epi.umn.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16172241

Citation

Anderson, Kristin E., et al. "Dietary Intake of Heterocyclic Amines and Benzo(a)pyrene: Associations With Pancreatic Cancer." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 14, no. 9, 2005, pp. 2261-5.
Anderson KE, Kadlubar FF, Kulldorff M, et al. Dietary intake of heterocyclic amines and benzo(a)pyrene: associations with pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2005;14(9):2261-5.
Anderson, K. E., Kadlubar, F. F., Kulldorff, M., Harnack, L., Gross, M., Lang, N. P., ... Sinha, R. (2005). Dietary intake of heterocyclic amines and benzo(a)pyrene: associations with pancreatic cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 14(9), pp. 2261-5.
Anderson KE, et al. Dietary Intake of Heterocyclic Amines and Benzo(a)pyrene: Associations With Pancreatic Cancer. Cancer Epidemiol Biomarkers Prev. 2005;14(9):2261-5. PubMed PMID: 16172241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of heterocyclic amines and benzo(a)pyrene: associations with pancreatic cancer. AU - Anderson,Kristin E, AU - Kadlubar,Fred F, AU - Kulldorff,Martin, AU - Harnack,Lisa, AU - Gross,Myron, AU - Lang,Nicholas P, AU - Barber,Cheryl, AU - Rothman,Nat, AU - Sinha,Rashmi, PY - 2005/9/21/pubmed PY - 2005/12/13/medline PY - 2005/9/21/entrez SP - 2261 EP - 5 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 14 IS - 9 N2 - OBJECTIVE: Heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons, formed in temperature- and time-dependent manners during the cooking of meat, are mutagens and carcinogens. We sought to assess the association between dietary intake of HCA and benzo(a)pyrene [B(a)P] and exocrine pancreatic cancer in a population-based case-control study. METHODS: Subjects (193 cases and 674 controls) provided information on their usual meat intake and preparation method, e.g., stewed, fried, or grilled/barbecued, etc. Meat doneness preferences were measured using photographs that showed internal doneness and external brownness. We used a meat-derived HCA, B(a)P, and mutagen database with a questionnaire to estimate intake of PhIP, DiMeIQx, MeIQx, B(a)P, and mutagenic activity (revertants/g of daily meat intake). Data were analyzed with unconditional logistic regression. RESULTS: In analyses adjusted for age, sex, smoking, education, race, and diabetes, the odds ratio and 95% confidence interval for the highest compared with the lowest quintile were as follows: PhIP, 1.8 (1.0-3.1); DiMeIQx, 2.0 (1.2-3.5); MeIQx, 1.5 (0.9-2.7); B(a)P, 2.2 (1.2-4.0); and mutagenic activity, 2.4 (1.3-4.3). CONCLUSIONS: HCAs and B(a)P from well-done barbecued and pan-fried meats may be associated with increased risk for pancreatic cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/16172241/Dietary_intake_of_heterocyclic_amines_and_benzo_a_pyrene:_associations_with_pancreatic_cancer_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=16172241 DB - PRIME DP - Unbound Medicine ER -