Abstract
OBJECTIVE
To compare the effects of cefdinir (14 mg/kg per day) and amoxicillin (90 mg/kg per day) antimicrobial therapy on the nasopharyngeal flora of children with acute otitis media.
DESIGN
Nasopharyngeal cultures for aerobic and facultative bacteria were obtained before therapy and 2 to 4 days after completion of therapy.
SETTING
Outpatient clinic.
PATIENTS
Fifty children, aged 7 months to 5 years 4 months.
MAIN OUTCOME MEASURES
After completion of therapy, 22 (88%) of the 25 patients treated with cefdinir and 16 (64%) of the 25 patients treated with amoxicillin were considered clinically cured (P<.05). A significant reduction in the number of all isolates occurred following therapy in those treated with cefdinir (36 vs 71, P<.01) or with amoxicillin (56 vs 73, P<.05). However, the total number of isolates recovered after therapy was significantly lower in those treated with cefdinir (36) compared with those treated with amoxicillin (56) (P<.01).
RESULTS
The recovery of potential pathogenic organisms (eg, Streptococcus pneumoniae, Staphylococcus aureus, beta-hemolytic streptococci, Haemophilus species, and Moraxella catarrhalis), as well as penicillin-resistant bacteria, was lower following completion of therapy in the cefdinir group (6 pathogens, including 5 that were penicillin resistant), compared with the amoxicillin group (27 pathogens, including 16 that were penicillin resistant) (P<.01).
CONCLUSION
This study illustrates the greater ability of cefdinir compared with amoxicillin to reduce the number of potential nasopharyngeal pathogens as well as penicillin-resistant bacteria in children with acute otitis media.
TY - JOUR
T1 - Effects of amoxicillin and cefdinir on nasopharyngeal bacterial flora.
AU - Brook,Itzhak,
AU - Gober,Alan E,
PY - 2005/9/21/pubmed
PY - 2005/10/14/medline
PY - 2005/9/21/entrez
SP - 785
EP - 7
JF - Archives of otolaryngology--head & neck surgery
JO - Arch Otolaryngol Head Neck Surg
VL - 131
IS - 9
N2 - OBJECTIVE: To compare the effects of cefdinir (14 mg/kg per day) and amoxicillin (90 mg/kg per day) antimicrobial therapy on the nasopharyngeal flora of children with acute otitis media. DESIGN: Nasopharyngeal cultures for aerobic and facultative bacteria were obtained before therapy and 2 to 4 days after completion of therapy. SETTING: Outpatient clinic. PATIENTS: Fifty children, aged 7 months to 5 years 4 months. MAIN OUTCOME MEASURES: After completion of therapy, 22 (88%) of the 25 patients treated with cefdinir and 16 (64%) of the 25 patients treated with amoxicillin were considered clinically cured (P<.05). A significant reduction in the number of all isolates occurred following therapy in those treated with cefdinir (36 vs 71, P<.01) or with amoxicillin (56 vs 73, P<.05). However, the total number of isolates recovered after therapy was significantly lower in those treated with cefdinir (36) compared with those treated with amoxicillin (56) (P<.01). RESULTS: The recovery of potential pathogenic organisms (eg, Streptococcus pneumoniae, Staphylococcus aureus, beta-hemolytic streptococci, Haemophilus species, and Moraxella catarrhalis), as well as penicillin-resistant bacteria, was lower following completion of therapy in the cefdinir group (6 pathogens, including 5 that were penicillin resistant), compared with the amoxicillin group (27 pathogens, including 16 that were penicillin resistant) (P<.01). CONCLUSION: This study illustrates the greater ability of cefdinir compared with amoxicillin to reduce the number of potential nasopharyngeal pathogens as well as penicillin-resistant bacteria in children with acute otitis media.
SN - 0886-4470
UR - https://www.unboundmedicine.com/medline/citation/16172355/Effects_of_amoxicillin_and_cefdinir_on_nasopharyngeal_bacterial_flora_
L2 - https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/10.1001/archotol.131.9.785
DB - PRIME
DP - Unbound Medicine
ER -
