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Effects of amoxicillin and cefdinir on nasopharyngeal bacterial flora.
Arch Otolaryngol Head Neck Surg. 2005 Sep; 131(9):785-7.AO

Abstract

OBJECTIVE

To compare the effects of cefdinir (14 mg/kg per day) and amoxicillin (90 mg/kg per day) antimicrobial therapy on the nasopharyngeal flora of children with acute otitis media.

DESIGN

Nasopharyngeal cultures for aerobic and facultative bacteria were obtained before therapy and 2 to 4 days after completion of therapy.

SETTING

Outpatient clinic.

PATIENTS

Fifty children, aged 7 months to 5 years 4 months.

MAIN OUTCOME MEASURES

After completion of therapy, 22 (88%) of the 25 patients treated with cefdinir and 16 (64%) of the 25 patients treated with amoxicillin were considered clinically cured (P<.05). A significant reduction in the number of all isolates occurred following therapy in those treated with cefdinir (36 vs 71, P<.01) or with amoxicillin (56 vs 73, P<.05). However, the total number of isolates recovered after therapy was significantly lower in those treated with cefdinir (36) compared with those treated with amoxicillin (56) (P<.01).

RESULTS

The recovery of potential pathogenic organisms (eg, Streptococcus pneumoniae, Staphylococcus aureus, beta-hemolytic streptococci, Haemophilus species, and Moraxella catarrhalis), as well as penicillin-resistant bacteria, was lower following completion of therapy in the cefdinir group (6 pathogens, including 5 that were penicillin resistant), compared with the amoxicillin group (27 pathogens, including 16 that were penicillin resistant) (P<.01).

CONCLUSION

This study illustrates the greater ability of cefdinir compared with amoxicillin to reduce the number of potential nasopharyngeal pathogens as well as penicillin-resistant bacteria in children with acute otitis media.

Authors+Show Affiliations

Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA. ib6@georgetown.eduNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16172355

Citation

Brook, Itzhak, and Alan E. Gober. "Effects of Amoxicillin and Cefdinir On Nasopharyngeal Bacterial Flora." Archives of Otolaryngology--head & Neck Surgery, vol. 131, no. 9, 2005, pp. 785-7.
Brook I, Gober AE. Effects of amoxicillin and cefdinir on nasopharyngeal bacterial flora. Arch Otolaryngol Head Neck Surg. 2005;131(9):785-7.
Brook, I., & Gober, A. E. (2005). Effects of amoxicillin and cefdinir on nasopharyngeal bacterial flora. Archives of Otolaryngology--head & Neck Surgery, 131(9), 785-7.
Brook I, Gober AE. Effects of Amoxicillin and Cefdinir On Nasopharyngeal Bacterial Flora. Arch Otolaryngol Head Neck Surg. 2005;131(9):785-7. PubMed PMID: 16172355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of amoxicillin and cefdinir on nasopharyngeal bacterial flora. AU - Brook,Itzhak, AU - Gober,Alan E, PY - 2005/9/21/pubmed PY - 2005/10/14/medline PY - 2005/9/21/entrez SP - 785 EP - 7 JF - Archives of otolaryngology--head & neck surgery JO - Arch Otolaryngol Head Neck Surg VL - 131 IS - 9 N2 - OBJECTIVE: To compare the effects of cefdinir (14 mg/kg per day) and amoxicillin (90 mg/kg per day) antimicrobial therapy on the nasopharyngeal flora of children with acute otitis media. DESIGN: Nasopharyngeal cultures for aerobic and facultative bacteria were obtained before therapy and 2 to 4 days after completion of therapy. SETTING: Outpatient clinic. PATIENTS: Fifty children, aged 7 months to 5 years 4 months. MAIN OUTCOME MEASURES: After completion of therapy, 22 (88%) of the 25 patients treated with cefdinir and 16 (64%) of the 25 patients treated with amoxicillin were considered clinically cured (P<.05). A significant reduction in the number of all isolates occurred following therapy in those treated with cefdinir (36 vs 71, P<.01) or with amoxicillin (56 vs 73, P<.05). However, the total number of isolates recovered after therapy was significantly lower in those treated with cefdinir (36) compared with those treated with amoxicillin (56) (P<.01). RESULTS: The recovery of potential pathogenic organisms (eg, Streptococcus pneumoniae, Staphylococcus aureus, beta-hemolytic streptococci, Haemophilus species, and Moraxella catarrhalis), as well as penicillin-resistant bacteria, was lower following completion of therapy in the cefdinir group (6 pathogens, including 5 that were penicillin resistant), compared with the amoxicillin group (27 pathogens, including 16 that were penicillin resistant) (P<.01). CONCLUSION: This study illustrates the greater ability of cefdinir compared with amoxicillin to reduce the number of potential nasopharyngeal pathogens as well as penicillin-resistant bacteria in children with acute otitis media. SN - 0886-4470 UR - https://www.unboundmedicine.com/medline/citation/16172355/Effects_of_amoxicillin_and_cefdinir_on_nasopharyngeal_bacterial_flora_ L2 - https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/10.1001/archotol.131.9.785 DB - PRIME DP - Unbound Medicine ER -