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Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis.
Mol Psychiatry 2006; 11(2):143-9MP

Abstract

Elevated plasma homocysteine concentration has been suggested as a risk factor for schizophrenia, but the results of epidemiological studies have been inconsistent. The most extensively studied genetic variant in the homocysteine metabolism is the 677C>T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, resulting in reduced enzyme activity and, subsequently, in elevated homocysteine. A meta-analysis of eight retrospective studies (812 cases and 2113 control subjects) was carried out to examine the association between homocysteine and schizophrenia. In addition, a meta-analysis of 10 studies (2265 cases and 2721 control subjects) on the homozygous (TT) genotype of the MTHFR 677C>T polymorphism was carried out to assess if this association is causal. A 5 micromol/l higher homocysteine level was associated with a 70% (95% confidence interval, CI: 27-129) higher risk of schizophrenia. The TT genotype was associated with a 36% (95% CI: 7-72) higher risk of schizophrenia compared to the CC genotype. The performed meta-analyses showed no evidence of publication bias or excessive influence attributable to any given study. In conclusion, our study provides evidence for an association of homocysteine with schizophrenia. The elevated risk of schizophrenia associated with the homozygous genotype of the MTHFR 677C>T polymorphism provides support for causality between a disturbed homocysteine metabolism and risk of schizophrenia.

Authors+Show Affiliations

GGz Nijmegen, Mental Health Institute Nijmegen, Nijmegen, and Department of Psychiatry, University Medical Center, Utrecht, The Netherlands. jmuntjewerff@ggznijmegen.nl

Pub Type(s)

Comparative Study
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16172608

Citation

Muntjewerff, J W., et al. "Homocysteine, Methylenetetrahydrofolate Reductase and Risk of Schizophrenia: a Meta-analysis." Molecular Psychiatry, vol. 11, no. 2, 2006, pp. 143-9.
Muntjewerff JW, Kahn RS, Blom HJ, et al. Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis. Mol Psychiatry. 2006;11(2):143-9.
Muntjewerff, J. W., Kahn, R. S., Blom, H. J., & den Heijer, M. (2006). Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis. Molecular Psychiatry, 11(2), pp. 143-9.
Muntjewerff JW, et al. Homocysteine, Methylenetetrahydrofolate Reductase and Risk of Schizophrenia: a Meta-analysis. Mol Psychiatry. 2006;11(2):143-9. PubMed PMID: 16172608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis. AU - Muntjewerff,J W, AU - Kahn,R S, AU - Blom,H J, AU - den Heijer,M, PY - 2005/9/21/pubmed PY - 2006/6/7/medline PY - 2005/9/21/entrez SP - 143 EP - 9 JF - Molecular psychiatry JO - Mol. Psychiatry VL - 11 IS - 2 N2 - Elevated plasma homocysteine concentration has been suggested as a risk factor for schizophrenia, but the results of epidemiological studies have been inconsistent. The most extensively studied genetic variant in the homocysteine metabolism is the 677C>T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, resulting in reduced enzyme activity and, subsequently, in elevated homocysteine. A meta-analysis of eight retrospective studies (812 cases and 2113 control subjects) was carried out to examine the association between homocysteine and schizophrenia. In addition, a meta-analysis of 10 studies (2265 cases and 2721 control subjects) on the homozygous (TT) genotype of the MTHFR 677C>T polymorphism was carried out to assess if this association is causal. A 5 micromol/l higher homocysteine level was associated with a 70% (95% confidence interval, CI: 27-129) higher risk of schizophrenia. The TT genotype was associated with a 36% (95% CI: 7-72) higher risk of schizophrenia compared to the CC genotype. The performed meta-analyses showed no evidence of publication bias or excessive influence attributable to any given study. In conclusion, our study provides evidence for an association of homocysteine with schizophrenia. The elevated risk of schizophrenia associated with the homozygous genotype of the MTHFR 677C>T polymorphism provides support for causality between a disturbed homocysteine metabolism and risk of schizophrenia. SN - 1359-4184 UR - https://www.unboundmedicine.com/medline/citation/16172608/Homocysteine_methylenetetrahydrofolate_reductase_and_risk_of_schizophrenia:_a_meta_analysis_ L2 - http://dx.doi.org/10.1038/sj.mp.4001746 DB - PRIME DP - Unbound Medicine ER -