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Noninvasive assessment of the tension-time index of inspiratory muscles at rest in obese male subjects.
Int J Obes (Lond). 2005 Dec; 29(12):1478-83.IJ

Abstract

OBJECTIVE

The aim of this study was to investigate the effect of excessive mechanical load caused by obesity on the inspiratory muscle performance in obese men at rest.

METHODS

We therefore measure at rest spirometric flows and the noninvasive tension time index of inspiratory muscle (TTmus = PI/PImax x TI/TTOT) in eight obese male subjects (body mass index (BMI) > 30) and 10 controls.

RESULTS

Spirometric flow (FEV1% pred, FVC% pred) and maximal inspiratory pressure (PImax) were significantly lower in obese subjects compared to controls (P < 0.001). The mean TTmus was significantly higher in obese subjects than in controls (0.136 +/- 0.003 vs 0.045 +/- 0.01). The increase in TTmus was primarily due to an increase in the ratio of mean inspiratory pressure to maximal inspiratory pressure (PI/PImax) and the duty cycle (TI/TTOT). We found a significant negative relationship between PImax and BMI (r = -0.74, P < 0.001), a positive correlation between TTmus and BMI (r = 0.80, P < 0.001) and a negative correlation between TTmus and forced expiratory volume in 1 s (r = -0.85, P < 0.001).

CONCLUSION

Excessive mechanical load caused by obesity imposes a great burden on the inspiratory muscle, which may predispose such subjects to respiratory muscle weakness at rest.

Authors+Show Affiliations

EA 3300 APS and Motor Patterns: Adaptations-Rehabilitation, Sport Science Department, Picardie Jules Verne University, Amiens Cedex, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16172620

Citation

Chlif, M, et al. "Noninvasive Assessment of the Tension-time Index of Inspiratory Muscles at Rest in Obese Male Subjects." International Journal of Obesity (2005), vol. 29, no. 12, 2005, pp. 1478-83.
Chlif M, Keochkerian D, Mourlhon C, et al. Noninvasive assessment of the tension-time index of inspiratory muscles at rest in obese male subjects. Int J Obes (Lond). 2005;29(12):1478-83.
Chlif, M., Keochkerian, D., Mourlhon, C., Choquet, D., & Ahmaidi, S. (2005). Noninvasive assessment of the tension-time index of inspiratory muscles at rest in obese male subjects. International Journal of Obesity (2005), 29(12), 1478-83.
Chlif M, et al. Noninvasive Assessment of the Tension-time Index of Inspiratory Muscles at Rest in Obese Male Subjects. Int J Obes (Lond). 2005;29(12):1478-83. PubMed PMID: 16172620.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Noninvasive assessment of the tension-time index of inspiratory muscles at rest in obese male subjects. AU - Chlif,M, AU - Keochkerian,D, AU - Mourlhon,C, AU - Choquet,D, AU - Ahmaidi,S, PY - 2005/9/21/pubmed PY - 2006/6/10/medline PY - 2005/9/21/entrez SP - 1478 EP - 83 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 29 IS - 12 N2 - OBJECTIVE: The aim of this study was to investigate the effect of excessive mechanical load caused by obesity on the inspiratory muscle performance in obese men at rest. METHODS: We therefore measure at rest spirometric flows and the noninvasive tension time index of inspiratory muscle (TTmus = PI/PImax x TI/TTOT) in eight obese male subjects (body mass index (BMI) > 30) and 10 controls. RESULTS: Spirometric flow (FEV1% pred, FVC% pred) and maximal inspiratory pressure (PImax) were significantly lower in obese subjects compared to controls (P < 0.001). The mean TTmus was significantly higher in obese subjects than in controls (0.136 +/- 0.003 vs 0.045 +/- 0.01). The increase in TTmus was primarily due to an increase in the ratio of mean inspiratory pressure to maximal inspiratory pressure (PI/PImax) and the duty cycle (TI/TTOT). We found a significant negative relationship between PImax and BMI (r = -0.74, P < 0.001), a positive correlation between TTmus and BMI (r = 0.80, P < 0.001) and a negative correlation between TTmus and forced expiratory volume in 1 s (r = -0.85, P < 0.001). CONCLUSION: Excessive mechanical load caused by obesity imposes a great burden on the inspiratory muscle, which may predispose such subjects to respiratory muscle weakness at rest. SN - 0307-0565 UR - https://www.unboundmedicine.com/medline/citation/16172620/Noninvasive_assessment_of_the_tension_time_index_of_inspiratory_muscles_at_rest_in_obese_male_subjects_ L2 - http://dx.doi.org/10.1038/sj.ijo.0803030 DB - PRIME DP - Unbound Medicine ER -