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Comparison of chloral hydrate, meperidine, and hydroxyzine to midazolam regimens for oral sedation of pediatric dental patients.
Pediatr Dent 2005 May-Jun; 27(3):191-7PD

Abstract

PURPOSE

The purpose of this retrospective study was to compare the effects of oral administration of a combination of chloral hydrate (CH) 25 mg/kg, hydroxyzine (H) 1 mg/kg, and meperidine (M) 1 mg/kg to midazolam 0.65 mg/kg using 50% nitrous oxide (N2O) on behavioral and physiological parameters of young children sedated for dental procedures. Factors associated with sedation effectiveness were identified, including age, preoperative behavior, and type of procedure.

METHODS

Records of 116 sedation sessions of 66 healthy, uncooperative children ages 24 to 60 months at The University of Iowa Centers for Disabilities and Development were reviewed. Patients received 1 of the 2 regimens. Intraoperative behavior was rated using a dichotomous scale. Physiological variables including heart rate and oxygen saturation were recorded at baseline and at 10-minute intervals of the session. Data were analyzed using SPSS Version 9.

RESULTS

Overall, 81 % of sessions were rated successful. Sedation sessions using CH+H+M combination had significantly higher success rate (P<.01, odds ratio=3.38, 95% confidence interval= 1.06 to 7.15) compared to sessions with midazolam. Sedation success was not associated with age, preoperative behavior, or type of dental procedure performed. Physiological variables were within the normal range for both regimens, although midazolam regimen recorded higher heart rates.

CONCLUSIONS

CH+H+M combination using 25 mg/kg CH resulted in significantly more effective sedation sessions compared to midazolam. Both regimens used 50% N2O and were found to be safe.

Authors+Show Affiliations

Pediatric Dentistry Program, The University of Iowa, College of Dentistry, Iowa City, Iowa, USA.No affiliation info available

Pub Type(s)

Comparative Study
Evaluation Studies
Journal Article

Language

eng

PubMed ID

16173222

Citation

Chowdhury, Jyoti, and Kaaren G. Vargas. "Comparison of Chloral Hydrate, Meperidine, and Hydroxyzine to Midazolam Regimens for Oral Sedation of Pediatric Dental Patients." Pediatric Dentistry, vol. 27, no. 3, 2005, pp. 191-7.
Chowdhury J, Vargas KG. Comparison of chloral hydrate, meperidine, and hydroxyzine to midazolam regimens for oral sedation of pediatric dental patients. Pediatr Dent. 2005;27(3):191-7.
Chowdhury, J., & Vargas, K. G. (2005). Comparison of chloral hydrate, meperidine, and hydroxyzine to midazolam regimens for oral sedation of pediatric dental patients. Pediatric Dentistry, 27(3), pp. 191-7.
Chowdhury J, Vargas KG. Comparison of Chloral Hydrate, Meperidine, and Hydroxyzine to Midazolam Regimens for Oral Sedation of Pediatric Dental Patients. Pediatr Dent. 2005;27(3):191-7. PubMed PMID: 16173222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of chloral hydrate, meperidine, and hydroxyzine to midazolam regimens for oral sedation of pediatric dental patients. AU - Chowdhury,Jyoti, AU - Vargas,Kaaren G, PY - 2005/9/22/pubmed PY - 2005/10/13/medline PY - 2005/9/22/entrez SP - 191 EP - 7 JF - Pediatric dentistry JO - Pediatr Dent VL - 27 IS - 3 N2 - PURPOSE: The purpose of this retrospective study was to compare the effects of oral administration of a combination of chloral hydrate (CH) 25 mg/kg, hydroxyzine (H) 1 mg/kg, and meperidine (M) 1 mg/kg to midazolam 0.65 mg/kg using 50% nitrous oxide (N2O) on behavioral and physiological parameters of young children sedated for dental procedures. Factors associated with sedation effectiveness were identified, including age, preoperative behavior, and type of procedure. METHODS: Records of 116 sedation sessions of 66 healthy, uncooperative children ages 24 to 60 months at The University of Iowa Centers for Disabilities and Development were reviewed. Patients received 1 of the 2 regimens. Intraoperative behavior was rated using a dichotomous scale. Physiological variables including heart rate and oxygen saturation were recorded at baseline and at 10-minute intervals of the session. Data were analyzed using SPSS Version 9. RESULTS: Overall, 81 % of sessions were rated successful. Sedation sessions using CH+H+M combination had significantly higher success rate (P<.01, odds ratio=3.38, 95% confidence interval= 1.06 to 7.15) compared to sessions with midazolam. Sedation success was not associated with age, preoperative behavior, or type of dental procedure performed. Physiological variables were within the normal range for both regimens, although midazolam regimen recorded higher heart rates. CONCLUSIONS: CH+H+M combination using 25 mg/kg CH resulted in significantly more effective sedation sessions compared to midazolam. Both regimens used 50% N2O and were found to be safe. SN - 0164-1263 UR - https://www.unboundmedicine.com/medline/citation/16173222/Comparison_of_chloral_hydrate_meperidine_and_hydroxyzine_to_midazolam_regimens_for_oral_sedation_of_pediatric_dental_patients_ L2 - https://www.ingentaconnect.com/openurl?genre=article&amp;issn=0164-1263&amp;volume=27&amp;issue=3&amp;spage=191&amp;aulast=Chowdhury DB - PRIME DP - Unbound Medicine ER -