Tags

Type your tag names separated by a space and hit enter

Prevention of oral mucositis due to 5-fluorouracil treatment with oral cryotherapy.
J Natl Med Assoc. 2005 Aug; 97(8):1161-4.JN

Abstract

INTRODUCTION

One of the most common and important side effects of 5-fluorouracil (5-FU) is mucositis with ulcerations in the oral cavity. We investigated the effects of local cryotherapy on mucositis incidence administrated durng 5-FU treatment.

METHODS

In a total of 99 courses, 5-FU and folinic acid combination chemotherapy was given to 40 patients. In our study, we considered every course as a single case, and cryotherapy was given to the same patient in one course but not given in the next.

RESULTS

While mucositis developed in 6.7% of the courses given with cryotherapy, this ratio was 38.9% in courses given without cryotherapy. In the logistic regression analysis, development of mucositis had been found to correlate only with cryotherapy. Odds ratio (OR) = 11.5; in the 95% confidence interval (CI) = 3.2 - 41.9; (p = 0.001).

DISCUSSION

Results of initial studies evaluating the effects of cryotherapy in preventing mucositis due to 5-FU based chemotherapy regimens were promising. We concluded that oral cooling prevents 5-FU induced mucositis. This effective prophylactic treatment should be used in patients who are at increased risk for developing 5-FU induced mucositis.

Authors+Show Affiliations

Inonu University, School of Medicine, Department of Hematology, Turgut Ozal Medical Center, Malatya, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16173332

Citation

Baydar, Mustafa, et al. "Prevention of Oral Mucositis Due to 5-fluorouracil Treatment With Oral Cryotherapy." Journal of the National Medical Association, vol. 97, no. 8, 2005, pp. 1161-4.
Baydar M, Dikilitas M, Sevinc A, et al. Prevention of oral mucositis due to 5-fluorouracil treatment with oral cryotherapy. J Natl Med Assoc. 2005;97(8):1161-4.
Baydar, M., Dikilitas, M., Sevinc, A., & Aydogdu, I. (2005). Prevention of oral mucositis due to 5-fluorouracil treatment with oral cryotherapy. Journal of the National Medical Association, 97(8), 1161-4.
Baydar M, et al. Prevention of Oral Mucositis Due to 5-fluorouracil Treatment With Oral Cryotherapy. J Natl Med Assoc. 2005;97(8):1161-4. PubMed PMID: 16173332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of oral mucositis due to 5-fluorouracil treatment with oral cryotherapy. AU - Baydar,Mustafa, AU - Dikilitas,Mustafa, AU - Sevinc,Alper, AU - Aydogdu,Ismet, PY - 2005/9/22/pubmed PY - 2005/10/22/medline PY - 2005/9/22/entrez SP - 1161 EP - 4 JF - Journal of the National Medical Association JO - J Natl Med Assoc VL - 97 IS - 8 N2 - INTRODUCTION: One of the most common and important side effects of 5-fluorouracil (5-FU) is mucositis with ulcerations in the oral cavity. We investigated the effects of local cryotherapy on mucositis incidence administrated durng 5-FU treatment. METHODS: In a total of 99 courses, 5-FU and folinic acid combination chemotherapy was given to 40 patients. In our study, we considered every course as a single case, and cryotherapy was given to the same patient in one course but not given in the next. RESULTS: While mucositis developed in 6.7% of the courses given with cryotherapy, this ratio was 38.9% in courses given without cryotherapy. In the logistic regression analysis, development of mucositis had been found to correlate only with cryotherapy. Odds ratio (OR) = 11.5; in the 95% confidence interval (CI) = 3.2 - 41.9; (p = 0.001). DISCUSSION: Results of initial studies evaluating the effects of cryotherapy in preventing mucositis due to 5-FU based chemotherapy regimens were promising. We concluded that oral cooling prevents 5-FU induced mucositis. This effective prophylactic treatment should be used in patients who are at increased risk for developing 5-FU induced mucositis. SN - 0027-9684 UR - https://www.unboundmedicine.com/medline/citation/16173332/Prevention_of_oral_mucositis_due_to_5_fluorouracil_treatment_with_oral_cryotherapy_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/16173332/ DB - PRIME DP - Unbound Medicine ER -