Tags

Type your tag names separated by a space and hit enter

Lesional characteristics and histopathology in paucibacillary leprosy patients with 2 or 3 skin lesions: comparison between ROM and PB-MDT regimens.
Indian J Lepr. 2005 Jan-Mar; 77(1):19-25.IJ

Abstract

Paucibacillary (PB) patients form a large segment of newly diagnosed leprosy patients and those who present with only two or three skin lesions could have problems with compliance. With prolonged anti-leprosy drug regimens that last over six months. ROM therapy, a one-dose regimen, offers an attractive alternative in treating such patients. We conducted a longitudinal study of 51 such PB patients, placing them in two groups at random: one receiving the standard PB-MDT regimen, and the other the ROM regimen. Patients were followed up for 2 years, with a comprehensive clinical examination done every six months. 14 patients, 7 in each group, also had their skin biopsies evaluated histopathologically at recruitment, at 6 months and at the end of 2 years. There was a consistent improvement of lesions in both the groups over time. The fall in granuloma fraction and the clearance of the initial bacterial index were seen in the histopathology of both groups. Although the PB-MDT regimen is an effective and robust one, the operational convenience and drug compliance with ROM could make it an acceptable, parallel regimen for PB patients when the disease is localized to 2 or 3 skin lesions.

Authors+Show Affiliations

Senior Specialist, TLMI, Naini, Allahabad 211 008, Uttar Pradesh, India.No affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16173416

Citation

Emmanuel, M, and M D. Gupte. "Lesional Characteristics and Histopathology in Paucibacillary Leprosy Patients With 2 or 3 Skin Lesions: Comparison Between ROM and PB-MDT Regimens." Indian Journal of Leprosy, vol. 77, no. 1, 2005, pp. 19-25.
Emmanuel M, Gupte MD. Lesional characteristics and histopathology in paucibacillary leprosy patients with 2 or 3 skin lesions: comparison between ROM and PB-MDT regimens. Indian J Lepr. 2005;77(1):19-25.
Emmanuel, M., & Gupte, M. D. (2005). Lesional characteristics and histopathology in paucibacillary leprosy patients with 2 or 3 skin lesions: comparison between ROM and PB-MDT regimens. Indian Journal of Leprosy, 77(1), 19-25.
Emmanuel M, Gupte MD. Lesional Characteristics and Histopathology in Paucibacillary Leprosy Patients With 2 or 3 Skin Lesions: Comparison Between ROM and PB-MDT Regimens. Indian J Lepr. 2005 Jan-Mar;77(1):19-25. PubMed PMID: 16173416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lesional characteristics and histopathology in paucibacillary leprosy patients with 2 or 3 skin lesions: comparison between ROM and PB-MDT regimens. AU - Emmanuel,M, AU - Gupte,M D, PY - 2005/9/22/pubmed PY - 2005/10/6/medline PY - 2005/9/22/entrez SP - 19 EP - 25 JF - Indian journal of leprosy JO - Indian J Lepr VL - 77 IS - 1 N2 - Paucibacillary (PB) patients form a large segment of newly diagnosed leprosy patients and those who present with only two or three skin lesions could have problems with compliance. With prolonged anti-leprosy drug regimens that last over six months. ROM therapy, a one-dose regimen, offers an attractive alternative in treating such patients. We conducted a longitudinal study of 51 such PB patients, placing them in two groups at random: one receiving the standard PB-MDT regimen, and the other the ROM regimen. Patients were followed up for 2 years, with a comprehensive clinical examination done every six months. 14 patients, 7 in each group, also had their skin biopsies evaluated histopathologically at recruitment, at 6 months and at the end of 2 years. There was a consistent improvement of lesions in both the groups over time. The fall in granuloma fraction and the clearance of the initial bacterial index were seen in the histopathology of both groups. Although the PB-MDT regimen is an effective and robust one, the operational convenience and drug compliance with ROM could make it an acceptable, parallel regimen for PB patients when the disease is localized to 2 or 3 skin lesions. SN - 0254-9395 UR - https://www.unboundmedicine.com/medline/citation/16173416/Lesional_characteristics_and_histopathology_in_paucibacillary_leprosy_patients_with_2_or_3_skin_lesions:_comparison_between_ROM_and_PB_MDT_regimens_ L2 - https://www.diseaseinfosearch.org/result/8733 DB - PRIME DP - Unbound Medicine ER -