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[Simultaneous vaccination against influenza and invasive pneumococcal disease in chronic dialysis patients].
Epidemiol Mikrobiol Imunol. 2005 Aug; 54(3):123-8.EM

Abstract

STUDY OBJECTIVE

To evaluate the antibody response to simultaneous vaccination against influeza and pneumococcal disease in chronic dialysis patients.

METHODS

Fifty-four chronic dialysis patients were vaccinated with subunit influenza vaccine Influvac. Thirty-five of these patients were vaccinated with both influenza vaccine and Pneumo 23 vaccine while 19 patients received influenza vaccine alone. Antibodies against influenza vaccine antigens were determined in paired sera by the hemagglutination inhibition test. The geometric mean titre (GMT) of antibodies, protection level (PR), seroconversion (SC) and conversion factor (CF) were calculated. The levels of antibodies against pneumococcal vaccine antigens were detected by the EIA and the geometric mean concentrations of antibodies were calculated from the results.

RESULTS

Simultaneous vaccination did not induce adequate PR for antigens A H1N1 and A H3N2, SC and CF for A H3N2 and B. Influenza vaccination alone resulted in inadequate PR and SC for A H3N2, with CF being adequate for all of the antigens. The geometric mean titres of antibodies were higher in the patients vaccinated with influenza vaccine alone, the difference not being statistically significant. Good responsiveness to the pneumococcal vaccine was observed, with the geometric mean concentrations of antibodies increasing 4.8 times after vaccination but decreasing to 1/3 a year later.

CONCLUSION

The antibody response to influenza vaccine was negatively influenced by immunodeficiency due to underlying diseases in dialysis patients. Although poorer results were achieved in patients vaccinated with influenza vaccine alone compared to those vaccinated with the two vaccines, the difference was not significant. An adjuvant influenza vaccine is expected to be more promising.

Authors+Show Affiliations

Trmal J
Krajská hygienická stanice, Usteckého kraje se sídlem v Ustí n/L. sekretar@khsusti.cz
Havlícková M
No affiliation info available
Bícová R
No affiliation info available
Bitterová Z
No affiliation info available
Kelerová J
No affiliation info available

MeSH

Antibodies, BacterialAntibodies, ViralFemaleHumansInfluenza A virusInfluenza VaccinesInfluenza, HumanMaleMiddle AgedPneumococcal InfectionsPneumococcal VaccinesRenal DialysisStreptococcus pneumoniae

Pub Type(s)

English Abstract
Journal Article

Language

cze

PubMed ID

16173523

Citation

Trmal, J, et al. "[Simultaneous Vaccination Against Influenza and Invasive Pneumococcal Disease in Chronic Dialysis Patients]." Epidemiologie, Mikrobiologie, Imunologie : Casopis Spolecnosti Pro Epidemiologii a Mikrobiologii Ceske Lekarske Spolecnosti J.E. Purkyne, vol. 54, no. 3, 2005, pp. 123-8.
Trmal J, Havlícková M, Bícová R, et al. [Simultaneous vaccination against influenza and invasive pneumococcal disease in chronic dialysis patients]. Epidemiol Mikrobiol Imunol. 2005;54(3):123-8.
Trmal, J., Havlícková, M., Bícová, R., Bitterová, Z., & Kelerová, J. (2005). [Simultaneous vaccination against influenza and invasive pneumococcal disease in chronic dialysis patients]. Epidemiologie, Mikrobiologie, Imunologie : Casopis Spolecnosti Pro Epidemiologii a Mikrobiologii Ceske Lekarske Spolecnosti J.E. Purkyne, 54(3), 123-8.
Trmal J, et al. [Simultaneous Vaccination Against Influenza and Invasive Pneumococcal Disease in Chronic Dialysis Patients]. Epidemiol Mikrobiol Imunol. 2005;54(3):123-8. PubMed PMID: 16173523.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Simultaneous vaccination against influenza and invasive pneumococcal disease in chronic dialysis patients]. AU - Trmal,J, AU - Havlícková,M, AU - Bícová,R, AU - Bitterová,Z, AU - Kelerová,J, PY - 2005/9/22/pubmed PY - 2005/11/9/medline PY - 2005/9/22/entrez SP - 123 EP - 8 JF - Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne JO - Epidemiol Mikrobiol Imunol VL - 54 IS - 3 N2 - STUDY OBJECTIVE: To evaluate the antibody response to simultaneous vaccination against influeza and pneumococcal disease in chronic dialysis patients. METHODS: Fifty-four chronic dialysis patients were vaccinated with subunit influenza vaccine Influvac. Thirty-five of these patients were vaccinated with both influenza vaccine and Pneumo 23 vaccine while 19 patients received influenza vaccine alone. Antibodies against influenza vaccine antigens were determined in paired sera by the hemagglutination inhibition test. The geometric mean titre (GMT) of antibodies, protection level (PR), seroconversion (SC) and conversion factor (CF) were calculated. The levels of antibodies against pneumococcal vaccine antigens were detected by the EIA and the geometric mean concentrations of antibodies were calculated from the results. RESULTS: Simultaneous vaccination did not induce adequate PR for antigens A H1N1 and A H3N2, SC and CF for A H3N2 and B. Influenza vaccination alone resulted in inadequate PR and SC for A H3N2, with CF being adequate for all of the antigens. The geometric mean titres of antibodies were higher in the patients vaccinated with influenza vaccine alone, the difference not being statistically significant. Good responsiveness to the pneumococcal vaccine was observed, with the geometric mean concentrations of antibodies increasing 4.8 times after vaccination but decreasing to 1/3 a year later. CONCLUSION: The antibody response to influenza vaccine was negatively influenced by immunodeficiency due to underlying diseases in dialysis patients. Although poorer results were achieved in patients vaccinated with influenza vaccine alone compared to those vaccinated with the two vaccines, the difference was not significant. An adjuvant influenza vaccine is expected to be more promising. SN - 1210-7913 UR - https://www.unboundmedicine.com/medline/citation/16173523/[Simultaneous_vaccination_against_influenza_and_invasive_pneumococcal_disease_in_chronic_dialysis_patients]_ DB - PRIME DP - Unbound Medicine ER -