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Variability of periodic leg movements in various sleep disorders: implications for clinical and pathophysiologic studies.
Sleep. 2005 Mar; 28(3):331-5.S

Abstract

STUDY OBJECTIVES

Periodic leg movements in sleep (PLMS) are a frequent phenomenon in various sleep disorders. The pathophysiology of PLMS is still not understood, but recent studies indicate a hypoactivity of the dopaminergic system in subjects with PLMS. In the present study, we investigated the intrasubject variance of PLMS from one night to the other because a fluctuation in the number of PLMS may influence the outcome of pharmacologic and pathophysiologic studies.

DESIGN

Retrospective observational study.

SETTING

Data collection occurred in the sleep disorders unit.

PATIENTS

Sleep electroencephalogram and PLMS data of 115 patients with PLMS monitoring over 2 consecutive nights were evaluated retrospectively. Patients were grouped into the following diagnostic categories: restless legs syndrome, insomnia secondary to a psychiatric disorder, primary insomnia, sleep apnea syndrome, and narcolepsy or idiopathic hypersomnia.

INTERVENTIONS

N/A.

RESULTS

In 27% of the entire patient population, we found a considerable variability of the PLMS index (difference between nights > 10/hour) and, in 19% of patients, variability of the PLMS arousal index (difference between nights > 5/hour) across the 2 investigated nights. The intraindividual variance occurred most frequently and to the highest extent in patients with RLS.

CONCLUSIONS

The variability of PLMS indexes should considered if the PLMS recording is performed in support of the clinical diagnosis or in the interpretation of studies investigating drug efficacy. Furthermore, the variability of PLMS may be an indicator of an instability of the dopaminergic system that should be taken into account in studies investigating central nervous system dopaminergic activity.

Authors+Show Affiliations

Sleep Disorders Unit, Department of Psychiatry and Psychotherapy, University Hospital, Freiburg, Germany. magdolna_hornyak@psyallg.ukl.uni-freiburg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16173654

Citation

Hornyak, Magdolna, et al. "Variability of Periodic Leg Movements in Various Sleep Disorders: Implications for Clinical and Pathophysiologic Studies." Sleep, vol. 28, no. 3, 2005, pp. 331-5.
Hornyak M, Kopasz M, Feige B, et al. Variability of periodic leg movements in various sleep disorders: implications for clinical and pathophysiologic studies. Sleep. 2005;28(3):331-5.
Hornyak, M., Kopasz, M., Feige, B., Riemann, D., & Voderholzer, U. (2005). Variability of periodic leg movements in various sleep disorders: implications for clinical and pathophysiologic studies. Sleep, 28(3), 331-5.
Hornyak M, et al. Variability of Periodic Leg Movements in Various Sleep Disorders: Implications for Clinical and Pathophysiologic Studies. Sleep. 2005;28(3):331-5. PubMed PMID: 16173654.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variability of periodic leg movements in various sleep disorders: implications for clinical and pathophysiologic studies. AU - Hornyak,Magdolna, AU - Kopasz,Marta, AU - Feige,Bernd, AU - Riemann,Dieter, AU - Voderholzer,Ulrich, PY - 2005/9/22/pubmed PY - 2005/12/16/medline PY - 2005/9/22/entrez SP - 331 EP - 5 JF - Sleep JO - Sleep VL - 28 IS - 3 N2 - STUDY OBJECTIVES: Periodic leg movements in sleep (PLMS) are a frequent phenomenon in various sleep disorders. The pathophysiology of PLMS is still not understood, but recent studies indicate a hypoactivity of the dopaminergic system in subjects with PLMS. In the present study, we investigated the intrasubject variance of PLMS from one night to the other because a fluctuation in the number of PLMS may influence the outcome of pharmacologic and pathophysiologic studies. DESIGN: Retrospective observational study. SETTING: Data collection occurred in the sleep disorders unit. PATIENTS: Sleep electroencephalogram and PLMS data of 115 patients with PLMS monitoring over 2 consecutive nights were evaluated retrospectively. Patients were grouped into the following diagnostic categories: restless legs syndrome, insomnia secondary to a psychiatric disorder, primary insomnia, sleep apnea syndrome, and narcolepsy or idiopathic hypersomnia. INTERVENTIONS: N/A. RESULTS: In 27% of the entire patient population, we found a considerable variability of the PLMS index (difference between nights > 10/hour) and, in 19% of patients, variability of the PLMS arousal index (difference between nights > 5/hour) across the 2 investigated nights. The intraindividual variance occurred most frequently and to the highest extent in patients with RLS. CONCLUSIONS: The variability of PLMS indexes should considered if the PLMS recording is performed in support of the clinical diagnosis or in the interpretation of studies investigating drug efficacy. Furthermore, the variability of PLMS may be an indicator of an instability of the dopaminergic system that should be taken into account in studies investigating central nervous system dopaminergic activity. SN - 0161-8105 UR - https://www.unboundmedicine.com/medline/citation/16173654/Variability_of_periodic_leg_movements_in_various_sleep_disorders:_implications_for_clinical_and_pathophysiologic_studies_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=16173654.ui DB - PRIME DP - Unbound Medicine ER -