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Introduction of HIV post-exposure prophylaxis for sexually abused children in Malawi.
Arch Dis Child. 2005 Dec; 90(12):1297-9.AD

Abstract

AIMS

To improve the care of children who are victims of child sexual abuse (CSA) by routinely assessing eligibility for HIV post-exposure prophylaxis (PEP) and to investigate the feasibility, safety, and efficacy of such treatment started in a paediatric emergency department in Malawi.

METHODS

Children presenting to the Queen Elizabeth Central Hospital, Blantyre between 1 January 2004 and 31 December 2004 with a history of alleged CSA were assessed for eligibility for HIV PEP and followed prospectively for six months.

RESULTS

A total of 64 children presented with a history of alleged CSA in the 12 month period; 17 were offered PEP. The remainder were not offered PEP because of absence of physical signs of abuse (n = 20), delay in presentation beyond 72 hours from assault (n = 11), repeated sexual abuse in the preceding six months (n = 15), and HIV infection found on initial testing (n = 1). No family refused an HIV test. No side effects due to antiretroviral therapy were reported. Of the 17 children commenced on PEP, 11 returned for review after one month, seven returned at three months, and two of 15 returned at six months post-assault. None have seroconverted.

CONCLUSIONS

In a resource-poor setting with a high HIV prevalence, HIV PEP following CSA is acceptable, safe, and feasible. HIV PEP should be incorporated in to national guidelines in countries with a high community prevalence of HIV infection.

Authors+Show Affiliations

Department of Paediatrics, College of Medicine, University of Malawi, Blantyre, Malawi. janeellis123@yahoo.co.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16174638

Citation

Ellis, J C., et al. "Introduction of HIV Post-exposure Prophylaxis for Sexually Abused Children in Malawi." Archives of Disease in Childhood, vol. 90, no. 12, 2005, pp. 1297-9.
Ellis JC, Ahmad S, Molyneux EM. Introduction of HIV post-exposure prophylaxis for sexually abused children in Malawi. Arch Dis Child. 2005;90(12):1297-9.
Ellis, J. C., Ahmad, S., & Molyneux, E. M. (2005). Introduction of HIV post-exposure prophylaxis for sexually abused children in Malawi. Archives of Disease in Childhood, 90(12), 1297-9.
Ellis JC, Ahmad S, Molyneux EM. Introduction of HIV Post-exposure Prophylaxis for Sexually Abused Children in Malawi. Arch Dis Child. 2005;90(12):1297-9. PubMed PMID: 16174638.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Introduction of HIV post-exposure prophylaxis for sexually abused children in Malawi. AU - Ellis,J C, AU - Ahmad,S, AU - Molyneux,E M, Y1 - 2005/09/20/ PY - 2005/9/22/pubmed PY - 2006/1/6/medline PY - 2005/9/22/entrez SP - 1297 EP - 9 JF - Archives of disease in childhood JO - Arch Dis Child VL - 90 IS - 12 N2 - AIMS: To improve the care of children who are victims of child sexual abuse (CSA) by routinely assessing eligibility for HIV post-exposure prophylaxis (PEP) and to investigate the feasibility, safety, and efficacy of such treatment started in a paediatric emergency department in Malawi. METHODS: Children presenting to the Queen Elizabeth Central Hospital, Blantyre between 1 January 2004 and 31 December 2004 with a history of alleged CSA were assessed for eligibility for HIV PEP and followed prospectively for six months. RESULTS: A total of 64 children presented with a history of alleged CSA in the 12 month period; 17 were offered PEP. The remainder were not offered PEP because of absence of physical signs of abuse (n = 20), delay in presentation beyond 72 hours from assault (n = 11), repeated sexual abuse in the preceding six months (n = 15), and HIV infection found on initial testing (n = 1). No family refused an HIV test. No side effects due to antiretroviral therapy were reported. Of the 17 children commenced on PEP, 11 returned for review after one month, seven returned at three months, and two of 15 returned at six months post-assault. None have seroconverted. CONCLUSIONS: In a resource-poor setting with a high HIV prevalence, HIV PEP following CSA is acceptable, safe, and feasible. HIV PEP should be incorporated in to national guidelines in countries with a high community prevalence of HIV infection. SN - 1468-2044 UR - https://www.unboundmedicine.com/medline/citation/16174638/Introduction_of_HIV_post_exposure_prophylaxis_for_sexually_abused_children_in_Malawi_ L2 - https://adc.bmj.com/lookup/pmidlookup?view=long&pmid=16174638 DB - PRIME DP - Unbound Medicine ER -