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Effects of a fish oil supplement on blood pressure and serum lipids in patients treated for coronary artery disease.
Can J Cardiol. 1992 Jan-Feb; 8(1):41-6.CJ

Abstract

OBJECTIVE

The purpose of this study was to evaluate the effects of a concentrate of fish oil on blood pressure and serum lipids in patients treated for coronary artery disease.

DESIGN

One hundred and twenty-five patients were randomly assigned to receive 15 g/day MaxEPA (4.5 g eicosapentaenoic and docosahexaenoic acids) or olive oil. Blood pressure and serum lipids were measured at enrollment and six months thereafter.

MAIN RESULTS

As an important proportion of antihypertensive or antianginal drug users stopped their usual medication during the trial, blood pressure increased in both groups. The increase in systolic blood pressure was less in the fish oil group than in the control group (P = 0.002). Serum triglyceride levels decreased markedly in the fish oil group while they remained constant in the control group (P = 0.0001). Fish oil supplementation had no effect on total cholesterol and only marginal independent influence on high density lipoprotein and low density lipoprotein cholesterol levels.

CONCLUSIONS

In conclusion, fish oil supplementation has a beneficial effect on blood pressure and serum triglycerides in patients treated for coronary artery disease.

Authors+Show Affiliations

Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Ste-Foy, Quebec.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1617510

Citation

Bairati, I, et al. "Effects of a Fish Oil Supplement On Blood Pressure and Serum Lipids in Patients Treated for Coronary Artery Disease." The Canadian Journal of Cardiology, vol. 8, no. 1, 1992, pp. 41-6.
Bairati I, Roy L, Meyer F. Effects of a fish oil supplement on blood pressure and serum lipids in patients treated for coronary artery disease. Can J Cardiol. 1992;8(1):41-6.
Bairati, I., Roy, L., & Meyer, F. (1992). Effects of a fish oil supplement on blood pressure and serum lipids in patients treated for coronary artery disease. The Canadian Journal of Cardiology, 8(1), 41-6.
Bairati I, Roy L, Meyer F. Effects of a Fish Oil Supplement On Blood Pressure and Serum Lipids in Patients Treated for Coronary Artery Disease. Can J Cardiol. 1992;8(1):41-6. PubMed PMID: 1617510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a fish oil supplement on blood pressure and serum lipids in patients treated for coronary artery disease. AU - Bairati,I, AU - Roy,L, AU - Meyer,F, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 41 EP - 6 JF - The Canadian journal of cardiology JO - Can J Cardiol VL - 8 IS - 1 N2 - OBJECTIVE: The purpose of this study was to evaluate the effects of a concentrate of fish oil on blood pressure and serum lipids in patients treated for coronary artery disease. DESIGN: One hundred and twenty-five patients were randomly assigned to receive 15 g/day MaxEPA (4.5 g eicosapentaenoic and docosahexaenoic acids) or olive oil. Blood pressure and serum lipids were measured at enrollment and six months thereafter. MAIN RESULTS: As an important proportion of antihypertensive or antianginal drug users stopped their usual medication during the trial, blood pressure increased in both groups. The increase in systolic blood pressure was less in the fish oil group than in the control group (P = 0.002). Serum triglyceride levels decreased markedly in the fish oil group while they remained constant in the control group (P = 0.0001). Fish oil supplementation had no effect on total cholesterol and only marginal independent influence on high density lipoprotein and low density lipoprotein cholesterol levels. CONCLUSIONS: In conclusion, fish oil supplementation has a beneficial effect on blood pressure and serum triglycerides in patients treated for coronary artery disease. SN - 0828-282X UR - https://www.unboundmedicine.com/medline/citation/1617510/Effects_of_a_fish_oil_supplement_on_blood_pressure_and_serum_lipids_in_patients_treated_for_coronary_artery_disease_ L2 - https://medlineplus.gov/cholesterollevelswhatyouneedtoknow.html DB - PRIME DP - Unbound Medicine ER -