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Modifying effects of sulfotransferase 1A1 gene polymorphism on the association of breast cancer risk with body mass index or endogenous steroid hormones.
Breast Cancer Res Treat. 2005 Nov; 94(1):63-70.BC

Abstract

Sulfotransferase (SULT) 1A1 is involved in the inactivation and elimination of estrogens and catechol estrogens. A common functional polymorphism (Arg213His) has been linked in our previous study of postmenopausal Caucasian women to an elevated risk of breast cancer and the association appeared to be modified by factors related to high endogenous estrogen exposures. We further evaluated this polymorphism and levels of BMI and steroid hormones in association with breast cancer risk in a population-based case-control study of Chinese women, involving 1102 incident cases aged 25-64 years and 1147 age-matched population controls. The SULT1A1 genotype was not associated with overall breast cancer risk in this population. A possible association was suggested for postmenopausal breast cancer (adjusted odds ratio [OR] = 1.4, 95% CI = 0.9-2.1 for subject carrying the variant His allele). The SULT1A1 genotype was found to significantly modify postmenopausal breast cancer risk associated with a high BMI (>or=25 kg/m2) (p for interaction = 0.02), with an adjusted OR of 3.6 (95% CI = 1.5-8.7) for women with the Arg/His genotype compared with 1.1 (0.8-1.5) for women with the Arg/Arg genotype (no His/His genotype was identified in this study population). Similarly, the risk associated with a long duration (>or=30 years) of menstruation also substantially differed by the SULT1A1 genotype (p for interaction = 0.05), with an OR of 4.0 (95% CI = 1.3-12.8) for women with the Arg/His genotype and 1.4 (0.8-2.5) for women with the Arg/Arg genotype. Positive associations with blood levels of steroid hormones were also found generally to be more pronounced among women carrying the His allele. No similar effect modification was found for premenopausal breast cancer, however. These data suggest that the SULT1A1 Arg213His polymorphism may modify the effect of endogenous sex hormone exposures on postmenopausal breast cancer risk.

Authors+Show Affiliations

Department of Medicine, Center for Health Services Research and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232-8300, USA. Gong.Yang@vanderbilt.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16175316

Citation

Yang, Gong, et al. "Modifying Effects of Sulfotransferase 1A1 Gene Polymorphism On the Association of Breast Cancer Risk With Body Mass Index or Endogenous Steroid Hormones." Breast Cancer Research and Treatment, vol. 94, no. 1, 2005, pp. 63-70.
Yang G, Gao YT, Cai QY, et al. Modifying effects of sulfotransferase 1A1 gene polymorphism on the association of breast cancer risk with body mass index or endogenous steroid hormones. Breast Cancer Res Treat. 2005;94(1):63-70.
Yang, G., Gao, Y. T., Cai, Q. Y., Shu, X. O., Cheng, J. R., & Zheng, W. (2005). Modifying effects of sulfotransferase 1A1 gene polymorphism on the association of breast cancer risk with body mass index or endogenous steroid hormones. Breast Cancer Research and Treatment, 94(1), 63-70.
Yang G, et al. Modifying Effects of Sulfotransferase 1A1 Gene Polymorphism On the Association of Breast Cancer Risk With Body Mass Index or Endogenous Steroid Hormones. Breast Cancer Res Treat. 2005;94(1):63-70. PubMed PMID: 16175316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modifying effects of sulfotransferase 1A1 gene polymorphism on the association of breast cancer risk with body mass index or endogenous steroid hormones. AU - Yang,Gong, AU - Gao,Yu-Tang, AU - Cai,Qiu-Yin, AU - Shu,Xiao-Ou, AU - Cheng,Jia-Rong, AU - Zheng,Wei, PY - 2005/9/22/pubmed PY - 2006/1/28/medline PY - 2005/9/22/entrez SP - 63 EP - 70 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 94 IS - 1 N2 - Sulfotransferase (SULT) 1A1 is involved in the inactivation and elimination of estrogens and catechol estrogens. A common functional polymorphism (Arg213His) has been linked in our previous study of postmenopausal Caucasian women to an elevated risk of breast cancer and the association appeared to be modified by factors related to high endogenous estrogen exposures. We further evaluated this polymorphism and levels of BMI and steroid hormones in association with breast cancer risk in a population-based case-control study of Chinese women, involving 1102 incident cases aged 25-64 years and 1147 age-matched population controls. The SULT1A1 genotype was not associated with overall breast cancer risk in this population. A possible association was suggested for postmenopausal breast cancer (adjusted odds ratio [OR] = 1.4, 95% CI = 0.9-2.1 for subject carrying the variant His allele). The SULT1A1 genotype was found to significantly modify postmenopausal breast cancer risk associated with a high BMI (>or=25 kg/m2) (p for interaction = 0.02), with an adjusted OR of 3.6 (95% CI = 1.5-8.7) for women with the Arg/His genotype compared with 1.1 (0.8-1.5) for women with the Arg/Arg genotype (no His/His genotype was identified in this study population). Similarly, the risk associated with a long duration (>or=30 years) of menstruation also substantially differed by the SULT1A1 genotype (p for interaction = 0.05), with an OR of 4.0 (95% CI = 1.3-12.8) for women with the Arg/His genotype and 1.4 (0.8-2.5) for women with the Arg/Arg genotype. Positive associations with blood levels of steroid hormones were also found generally to be more pronounced among women carrying the His allele. No similar effect modification was found for premenopausal breast cancer, however. These data suggest that the SULT1A1 Arg213His polymorphism may modify the effect of endogenous sex hormone exposures on postmenopausal breast cancer risk. SN - 0167-6806 UR - https://www.unboundmedicine.com/medline/citation/16175316/Modifying_effects_of_sulfotransferase_1A1_gene_polymorphism_on_the_association_of_breast_cancer_risk_with_body_mass_index_or_endogenous_steroid_hormones_ L2 - https://doi.org/10.1007/s10549-005-7280-2 DB - PRIME DP - Unbound Medicine ER -