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Hemodynamic effects of pumpless extracorporeal membrane oxygenation (ECMO) support for chronically pressure-overloaded right heart failure in a canine experimental model.
Surg Today. 2005; 35(10):861-8.ST

Abstract

PURPOSE

This study was done to evaluate the hemodynamic effects of a pumpless implantable extracorporeal membrane oxygenation (ECMO) circuit between the right ventricle (RV) and left atrium (LA) in a chronic canine model with an RV pressure overload.

METHOD

We created a model of right-sided heart failure by pulmonary artery banding in ten dogs for a duration of more than 3 months. After demonstrating that the RV pressure increased, a bypass circuit was created between the RV and LA with an in-line oxygenator. Both the hemodynamics and gas exchange were measured.

RESULTS

The effects of a pulmonary bypass in nine dogs were studied. Approximately half of the RV output was passively shunted through the bypass circuit, and a marked reduction in the RV pressure and recovery from right heart failure were observed. After a complete ligation of the main pulmonary artery, five of the nine dogs survived more than 6 h. The RV pressure did not change significantly, but the cardiac output and blood pressure gradually decreased. The blood gas state was sufficiently maintained throughout the experiment.

CONCLUSION

The present study indicates the hemodynamic benefit of a partial pumpless ECMO system in dogs with chronically pressure-overloaded right heart failure; however, the experimental preparation of the total pumpless ECMO circuit proved to be unstable.

Authors+Show Affiliations

Tamesue K
Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-0914, Japan.
Nawa S
No affiliation info available
Ichiba S
No affiliation info available
Aoe M
No affiliation info available
Date H
No affiliation info available
Shimizu N
No affiliation info available

MeSH

AnimalsAnimals, NewbornBlood Gas AnalysisChronic DiseaseDisease Models, AnimalDogsExtracorporeal Membrane OxygenationHeart FailureHemodynamicsPressureProbabilityRisk AssessmentSensitivity and SpecificityTreatment OutcomeVentricular Dysfunction, Right

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16175468

Citation

Tamesue, Kiyokazu, et al. "Hemodynamic Effects of Pumpless Extracorporeal Membrane Oxygenation (ECMO) Support for Chronically Pressure-overloaded Right Heart Failure in a Canine Experimental Model." Surgery Today, vol. 35, no. 10, 2005, pp. 861-8.
Tamesue K, Nawa S, Ichiba S, et al. Hemodynamic effects of pumpless extracorporeal membrane oxygenation (ECMO) support for chronically pressure-overloaded right heart failure in a canine experimental model. Surg Today. 2005;35(10):861-8.
Tamesue, K., Nawa, S., Ichiba, S., Aoe, M., Date, H., & Shimizu, N. (2005). Hemodynamic effects of pumpless extracorporeal membrane oxygenation (ECMO) support for chronically pressure-overloaded right heart failure in a canine experimental model. Surgery Today, 35(10), 861-8.
Tamesue K, et al. Hemodynamic Effects of Pumpless Extracorporeal Membrane Oxygenation (ECMO) Support for Chronically Pressure-overloaded Right Heart Failure in a Canine Experimental Model. Surg Today. 2005;35(10):861-8. PubMed PMID: 16175468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hemodynamic effects of pumpless extracorporeal membrane oxygenation (ECMO) support for chronically pressure-overloaded right heart failure in a canine experimental model. AU - Tamesue,Kiyokazu, AU - Nawa,Sugato, AU - Ichiba,Shingo, AU - Aoe,Motoi, AU - Date,Hiroshi, AU - Shimizu,Nobuyoshi, PY - 2004/06/22/received PY - 2005/01/18/accepted PY - 2005/9/22/pubmed PY - 2006/4/28/medline PY - 2005/9/22/entrez SP - 861 EP - 8 JF - Surgery today JO - Surg Today VL - 35 IS - 10 N2 - PURPOSE: This study was done to evaluate the hemodynamic effects of a pumpless implantable extracorporeal membrane oxygenation (ECMO) circuit between the right ventricle (RV) and left atrium (LA) in a chronic canine model with an RV pressure overload. METHOD: We created a model of right-sided heart failure by pulmonary artery banding in ten dogs for a duration of more than 3 months. After demonstrating that the RV pressure increased, a bypass circuit was created between the RV and LA with an in-line oxygenator. Both the hemodynamics and gas exchange were measured. RESULTS: The effects of a pulmonary bypass in nine dogs were studied. Approximately half of the RV output was passively shunted through the bypass circuit, and a marked reduction in the RV pressure and recovery from right heart failure were observed. After a complete ligation of the main pulmonary artery, five of the nine dogs survived more than 6 h. The RV pressure did not change significantly, but the cardiac output and blood pressure gradually decreased. The blood gas state was sufficiently maintained throughout the experiment. CONCLUSION: The present study indicates the hemodynamic benefit of a partial pumpless ECMO system in dogs with chronically pressure-overloaded right heart failure; however, the experimental preparation of the total pumpless ECMO circuit proved to be unstable. SN - 0941-1291 UR - https://www.unboundmedicine.com/medline/citation/16175468/Hemodynamic_effects_of_pumpless_extracorporeal_membrane_oxygenation__ECMO__support_for_chronically_pressure_overloaded_right_heart_failure_in_a_canine_experimental_model_ DB - PRIME DP - Unbound Medicine ER -