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Evaluation of periodic leg movements and associated transcranial magnetic stimulation parameters in restless legs syndrome.
Muscle Nerve. 2006 Jan; 33(1):133-7.MN

Abstract

Restless legs syndrome (RLS), a sensorimotor disorder characterized by unpleasant sensations commonly localized in the legs, is frequently associated with periodic limb movements (PLMs) during sleep. We investigated the role of transcranial magnetic stimulation (TMS) and cortical silent period (CSP) duration as diagnostic and monitoring tools in 20 patients with primary RLS before and after 1 month of treatment and also studied 15 normal age- and gender-matched subjects. Polysomnographic assessment was undertaken and the PLM index determined in 17 of the 20 patients. We also studied the correlation between sleep efficiency index and CSP duration because of the increasing severity of the sleep disturbance and PLMs in patients with RLS. Our results demonstrate that the duration of the CSP was reduced in patients with RLS, and that dopaminergic treatment normalized this duration. There was no correlation between the PLM index and CSP duration. It may be speculated that PLMs and the CSP are due to different inhibitory mechanisms and they may be used separately as diagnostic and monitoring tools in patients with primary RLS.

Authors+Show Affiliations

Department of Neurology, Gulhane Military Medical Academy, 06018 Etlik, Ankara, Turkey. ykutukcu@gata.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

16175624

Citation

Kutukcu, Yasar, et al. "Evaluation of Periodic Leg Movements and Associated Transcranial Magnetic Stimulation Parameters in Restless Legs Syndrome." Muscle & Nerve, vol. 33, no. 1, 2006, pp. 133-7.
Kutukcu Y, Dogruer E, Yetkin S, et al. Evaluation of periodic leg movements and associated transcranial magnetic stimulation parameters in restless legs syndrome. Muscle Nerve. 2006;33(1):133-7.
Kutukcu, Y., Dogruer, E., Yetkin, S., Ozgen, F., Vural, O., & Aydin, H. (2006). Evaluation of periodic leg movements and associated transcranial magnetic stimulation parameters in restless legs syndrome. Muscle & Nerve, 33(1), 133-7.
Kutukcu Y, et al. Evaluation of Periodic Leg Movements and Associated Transcranial Magnetic Stimulation Parameters in Restless Legs Syndrome. Muscle Nerve. 2006;33(1):133-7. PubMed PMID: 16175624.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of periodic leg movements and associated transcranial magnetic stimulation parameters in restless legs syndrome. AU - Kutukcu,Yasar, AU - Dogruer,Erhan, AU - Yetkin,Sinan, AU - Ozgen,Fuat, AU - Vural,Okay, AU - Aydin,Hamdullah, PY - 2005/9/22/pubmed PY - 2006/3/18/medline PY - 2005/9/22/entrez SP - 133 EP - 7 JF - Muscle & nerve JO - Muscle Nerve VL - 33 IS - 1 N2 - Restless legs syndrome (RLS), a sensorimotor disorder characterized by unpleasant sensations commonly localized in the legs, is frequently associated with periodic limb movements (PLMs) during sleep. We investigated the role of transcranial magnetic stimulation (TMS) and cortical silent period (CSP) duration as diagnostic and monitoring tools in 20 patients with primary RLS before and after 1 month of treatment and also studied 15 normal age- and gender-matched subjects. Polysomnographic assessment was undertaken and the PLM index determined in 17 of the 20 patients. We also studied the correlation between sleep efficiency index and CSP duration because of the increasing severity of the sleep disturbance and PLMs in patients with RLS. Our results demonstrate that the duration of the CSP was reduced in patients with RLS, and that dopaminergic treatment normalized this duration. There was no correlation between the PLM index and CSP duration. It may be speculated that PLMs and the CSP are due to different inhibitory mechanisms and they may be used separately as diagnostic and monitoring tools in patients with primary RLS. SN - 0148-639X UR - https://www.unboundmedicine.com/medline/citation/16175624/Evaluation_of_periodic_leg_movements_and_associated_transcranial_magnetic_stimulation_parameters_in_restless_legs_syndrome_ L2 - https://doi.org/10.1002/mus.20427 DB - PRIME DP - Unbound Medicine ER -