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Effectiveness of the first district-wide programme for the prevention of mother-to-child transmission of HIV in South Africa.
Bull World Health Organ. 2005 Jul; 83(7):489-94.BW

Abstract

OBJECTIVE

The aim of this study was to estimate the field efficacy of the first routine programme for the prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV) initiated in South Africa, in the subdistrict of Khayelitsha.

METHODS

A consecutive sample of 658 mother-infant pairs, identified from the PMTCT register from 1 March to 30 November 2003, were identified for enrolment in this study. Details of the regimen received were established and HIV status of the infants at between 6 and 10 weeks of age was determined by qualitative DNA polymerase chain reaction. Zidovudine (AZT) was provided antenatally from week 34 of gestation and during labour. Infant formula milk was-offered to mothers who chose not to breastfeed. The protocol was amended in July 2003 such that women who had received < 2 weeks of treatment with AZT were given a single dose of nevirapine (NVP) at the onset of labour, and the infant received a weight-adjusted dose of NVP within 72 h of delivery.

RESULTS

Of the 535 mother-infant pairs (81%) eventually included in the study, 410 (77%) received an effective PMTCT intervention according to the protocol. The rate of transmission of HIV from mother to child was 8.8% (95% confidence interval (CI), 6.2-10.9). A maternal age of > 25 years was the only significant independent risk factor for transmission (odds ratio, 2.12; 95% CI, 1.14-4.07).

CONCLUSION

The results of this study demonstrate the feasibility and effectiveness of a large-scale PMTCT programme in an urban public-sector setting.

Authors+Show Affiliations

Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa. dcoetzee@phfm.uct.ac.zaNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16175822

Citation

Coetzee, David, et al. "Effectiveness of the First District-wide Programme for the Prevention of Mother-to-child Transmission of HIV in South Africa." Bulletin of the World Health Organization, vol. 83, no. 7, 2005, pp. 489-94.
Coetzee D, Hilderbrand K, Boulle A, et al. Effectiveness of the first district-wide programme for the prevention of mother-to-child transmission of HIV in South Africa. Bull World Health Organ. 2005;83(7):489-94.
Coetzee, D., Hilderbrand, K., Boulle, A., Draper, B., Abdullah, F., & Goemaere, E. (2005). Effectiveness of the first district-wide programme for the prevention of mother-to-child transmission of HIV in South Africa. Bulletin of the World Health Organization, 83(7), 489-94.
Coetzee D, et al. Effectiveness of the First District-wide Programme for the Prevention of Mother-to-child Transmission of HIV in South Africa. Bull World Health Organ. 2005;83(7):489-94. PubMed PMID: 16175822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of the first district-wide programme for the prevention of mother-to-child transmission of HIV in South Africa. AU - Coetzee,David, AU - Hilderbrand,Katherine, AU - Boulle,Andrew, AU - Draper,Beverley, AU - Abdullah,Fareed, AU - Goemaere,Eric, PY - 2005/9/24/pubmed PY - 2005/12/13/medline PY - 2005/9/24/entrez SP - 489 EP - 94 JF - Bulletin of the World Health Organization JO - Bull. World Health Organ. VL - 83 IS - 7 N2 - OBJECTIVE: The aim of this study was to estimate the field efficacy of the first routine programme for the prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV) initiated in South Africa, in the subdistrict of Khayelitsha. METHODS: A consecutive sample of 658 mother-infant pairs, identified from the PMTCT register from 1 March to 30 November 2003, were identified for enrolment in this study. Details of the regimen received were established and HIV status of the infants at between 6 and 10 weeks of age was determined by qualitative DNA polymerase chain reaction. Zidovudine (AZT) was provided antenatally from week 34 of gestation and during labour. Infant formula milk was-offered to mothers who chose not to breastfeed. The protocol was amended in July 2003 such that women who had received < 2 weeks of treatment with AZT were given a single dose of nevirapine (NVP) at the onset of labour, and the infant received a weight-adjusted dose of NVP within 72 h of delivery. RESULTS: Of the 535 mother-infant pairs (81%) eventually included in the study, 410 (77%) received an effective PMTCT intervention according to the protocol. The rate of transmission of HIV from mother to child was 8.8% (95% confidence interval (CI), 6.2-10.9). A maternal age of > 25 years was the only significant independent risk factor for transmission (odds ratio, 2.12; 95% CI, 1.14-4.07). CONCLUSION: The results of this study demonstrate the feasibility and effectiveness of a large-scale PMTCT programme in an urban public-sector setting. SN - 0042-9686 UR - https://www.unboundmedicine.com/medline/citation/16175822/Effectiveness_of_the_first_district_wide_programme_for_the_prevention_of_mother_to_child_transmission_of_HIV_in_South_Africa_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/16175822/ DB - PRIME DP - Unbound Medicine ER -