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Relationship between body mass index and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort (JACC) study.
J Obstet Gynaecol Res 2005; 31(5):452-8JO

Abstract

AIM

The incidence of ovarian cancer in Japan has increased since the 1970s. The many studies that have assessed the relationship between body mass index (BMI) and the risk of ovarian cancer have produced contradictory results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk, which was initiated in 1988.

METHODS

A self-administered questionnaire on dietary habits and other risk factors for cancer was completed by 36,456 Japanese women. After 7.6 years of follow up, 38 cases of ovarian cancer were available for analysis. Cox proportional-hazards models were used to compute relative risks and to adjust for confounders.

RESULTS

Compared to women with BMI of 18.5-24.9 kg/m2, the relative risk of ovarian cancer was 2.24 (95% CI = 1.10-4.21) for BMI of 25.0-29.9 and 1.78 (95% CI = 0.24-13.34) for BMI of > or = 30 kg/m2. A test for trend revealed that this finding was statistically significant (P = 0.014).

CONCLUSION

The results of this study suggest that being overweight is independently associated with a higher risk of developing ovarian cancer in the Japanese population.

Authors+Show Affiliations

Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan. niwa@aichi-cc.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

16176517

Citation

Niwa, Yoshimitsu, et al. "Relationship Between Body Mass Index and the Risk of Ovarian Cancer in the Japanese Population: Findings From the Japanese Collaborate Cohort (JACC) Study." The Journal of Obstetrics and Gynaecology Research, vol. 31, no. 5, 2005, pp. 452-8.
Niwa Y, Yatsuya H, Tamakoshi K, et al. Relationship between body mass index and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort (JACC) study. J Obstet Gynaecol Res. 2005;31(5):452-8.
Niwa, Y., Yatsuya, H., Tamakoshi, K., Nishio, K., Kondo, T., Lin, Y., ... Tamakoshi, A. (2005). Relationship between body mass index and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort (JACC) study. The Journal of Obstetrics and Gynaecology Research, 31(5), pp. 452-8.
Niwa Y, et al. Relationship Between Body Mass Index and the Risk of Ovarian Cancer in the Japanese Population: Findings From the Japanese Collaborate Cohort (JACC) Study. J Obstet Gynaecol Res. 2005;31(5):452-8. PubMed PMID: 16176517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between body mass index and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort (JACC) study. AU - Niwa,Yoshimitsu, AU - Yatsuya,Hiroshi, AU - Tamakoshi,Koji, AU - Nishio,Kazuko, AU - Kondo,Takaaki, AU - Lin,Yingsong, AU - Suzuki,Sadao, AU - Wakai,Kenji, AU - Tokudome,Shinkan, AU - Yamamoto,Akio, AU - Hamajima,Nobuyuki, AU - Toyoshima,Hideaki, AU - Tamakoshi,Akiko, AU - ,, PY - 2005/9/24/pubmed PY - 2005/12/15/medline PY - 2005/9/24/entrez SP - 452 EP - 8 JF - The journal of obstetrics and gynaecology research JO - J. Obstet. Gynaecol. Res. VL - 31 IS - 5 N2 - AIM: The incidence of ovarian cancer in Japan has increased since the 1970s. The many studies that have assessed the relationship between body mass index (BMI) and the risk of ovarian cancer have produced contradictory results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk, which was initiated in 1988. METHODS: A self-administered questionnaire on dietary habits and other risk factors for cancer was completed by 36,456 Japanese women. After 7.6 years of follow up, 38 cases of ovarian cancer were available for analysis. Cox proportional-hazards models were used to compute relative risks and to adjust for confounders. RESULTS: Compared to women with BMI of 18.5-24.9 kg/m2, the relative risk of ovarian cancer was 2.24 (95% CI = 1.10-4.21) for BMI of 25.0-29.9 and 1.78 (95% CI = 0.24-13.34) for BMI of > or = 30 kg/m2. A test for trend revealed that this finding was statistically significant (P = 0.014). CONCLUSION: The results of this study suggest that being overweight is independently associated with a higher risk of developing ovarian cancer in the Japanese population. SN - 1341-8076 UR - https://www.unboundmedicine.com/medline/citation/16176517/Relationship_between_body_mass_index_and_the_risk_of_ovarian_cancer_in_the_Japanese_population:_findings_from_the_Japanese_Collaborate_Cohort__JACC__study_ L2 - https://doi.org/10.1111/j.1447-0756.2005.00319.x DB - PRIME DP - Unbound Medicine ER -