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Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24 h energy expenditure and fat oxidation in men.

Abstract

It has been reported that green tea has a thermogenic effect, due to its caffeine content and probably also to the catechin, epigallocatechin-3-gallate (EGCG). The main aim of the present study was to compare the effect of a mixture of green tea and Guarana extracts containing a fixed dose of caffeine and variable doses of EGCG on 24 h energy expenditure and fat oxidation. Fourteen subjects took part to this randomized, placebo-controlled, double-blind, cross-over study. Each subject was tested five times in a metabolic chamber to measure 24 h energy expenditure, substrate oxidation and blood pressure. During each stay, the subjects ingested a capsule of placebo or capsules containing 200 mg caffeine and a variable dose of EGCG (90, 200, 300 or 400 mg) three times daily, 30 min before standardized meals. Twenty-four hour energy expenditure increased significantly by about 750 kJ with all EGCG-caffeine mixtures compared with placebo. No effect of the EGCG-caffeine mixture was observed for lipid oxidation. Systolic and diastolic blood pressure increased by about 7 and 5 mmHg, respectively, with the EGCG-caffeine mixtures compared with placebo. This increase was significant only for 24 h diastolic blood pressure. The main finding of the study was the increase in 24 h energy expenditure with the EGCG-caffeine mixtures. However, this increase was similar with all doses of EGCG in the mixtures.

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  • Authors+Show Affiliations

    ,

    Division of Kinesiology, Laval University, Ste-Foy, Québec, Canada, G1K 7P4.

    , ,

    Source

    The British journal of nutrition 94:3 2005 Sep pg 432-6

    MeSH

    Adult
    Analysis of Variance
    Area Under Curve
    Beverages
    Caffeine
    Calorimetry, Indirect
    Catechin
    Central Nervous System Stimulants
    Cross-Over Studies
    Dose-Response Relationship, Drug
    Double-Blind Method
    Energy Metabolism
    Humans
    Male
    Middle Aged
    Oxidation-Reduction
    Paullinia
    Plant Extracts
    Tea
    Thermogenesis

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16176615

    Citation

    Bérubé-Parent, Sonia, et al. "Effects of Encapsulated Green Tea and Guarana Extracts Containing a Mixture of Epigallocatechin-3-gallate and Caffeine On 24 H Energy Expenditure and Fat Oxidation in Men." The British Journal of Nutrition, vol. 94, no. 3, 2005, pp. 432-6.
    Bérubé-Parent S, Pelletier C, Doré J, et al. Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24 h energy expenditure and fat oxidation in men. Br J Nutr. 2005;94(3):432-6.
    Bérubé-Parent, S., Pelletier, C., Doré, J., & Tremblay, A. (2005). Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24 h energy expenditure and fat oxidation in men. The British Journal of Nutrition, 94(3), pp. 432-6.
    Bérubé-Parent S, et al. Effects of Encapsulated Green Tea and Guarana Extracts Containing a Mixture of Epigallocatechin-3-gallate and Caffeine On 24 H Energy Expenditure and Fat Oxidation in Men. Br J Nutr. 2005;94(3):432-6. PubMed PMID: 16176615.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24 h energy expenditure and fat oxidation in men. AU - Bérubé-Parent,Sonia, AU - Pelletier,Catherine, AU - Doré,Jean, AU - Tremblay,Angelo, PY - 2005/9/24/pubmed PY - 2005/11/3/medline PY - 2005/9/24/entrez SP - 432 EP - 6 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 94 IS - 3 N2 - It has been reported that green tea has a thermogenic effect, due to its caffeine content and probably also to the catechin, epigallocatechin-3-gallate (EGCG). The main aim of the present study was to compare the effect of a mixture of green tea and Guarana extracts containing a fixed dose of caffeine and variable doses of EGCG on 24 h energy expenditure and fat oxidation. Fourteen subjects took part to this randomized, placebo-controlled, double-blind, cross-over study. Each subject was tested five times in a metabolic chamber to measure 24 h energy expenditure, substrate oxidation and blood pressure. During each stay, the subjects ingested a capsule of placebo or capsules containing 200 mg caffeine and a variable dose of EGCG (90, 200, 300 or 400 mg) three times daily, 30 min before standardized meals. Twenty-four hour energy expenditure increased significantly by about 750 kJ with all EGCG-caffeine mixtures compared with placebo. No effect of the EGCG-caffeine mixture was observed for lipid oxidation. Systolic and diastolic blood pressure increased by about 7 and 5 mmHg, respectively, with the EGCG-caffeine mixtures compared with placebo. This increase was significant only for 24 h diastolic blood pressure. The main finding of the study was the increase in 24 h energy expenditure with the EGCG-caffeine mixtures. However, this increase was similar with all doses of EGCG in the mixtures. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/16176615/Effects_of_encapsulated_green_tea_and_Guarana_extracts_containing_a_mixture_of_epigallocatechin_3_gallate_and_caffeine_on_24_h_energy_expenditure_and_fat_oxidation_in_men_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=16176615.ui DB - PRIME DP - Unbound Medicine ER -