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Occupational exposure to pesticides and risk of non-Hodgkin's lymphoma.
Am J Epidemiol 2005; 162(9):849-57AJ

Abstract

Pesticide exposure may be a risk factor for non-Hodgkin's lymphoma, but it is not certain which types of pesticides are involved. A population-based case-control study was undertaken in 2000-2001 using detailed methods of assessing occupational pesticide exposure. Cases with incident non-Hodgkin's lymphoma in two Australian states (n = 694) and controls (n = 694) were chosen from Australian electoral rolls. Logistic regression was used to estimate the risks of non-Hodgkin's lymphoma associated with exposure to subgroups of pesticides after adjustment for age, sex, ethnic origin, and residence. Approximately 10% of cases and controls had incurred pesticide exposure. Substantial exposure to any pesticide was associated with a trebling of the risk of non-Hodgkin's lymphoma (odds ratio = 3.09, 95% confidence interval: 1.42, 6.70). Subjects with substantial exposure to organochlorines, organophosphates, and "other pesticides" (all other pesticides excluding herbicides) and herbicides other than phenoxy herbicides had similarly increased risks, although the increase was statistically significant only for "other pesticides." None of the exposure metrics (probability, level, frequency, duration, or years of exposure) were associated with non-Hodgkin's lymphoma. Analyses of the major World Health Organization subtypes of non-Hodgkin's lymphoma suggested a stronger effect for follicular lymphoma. These increases in risk of non-Hodgkin's lymphoma with substantial occupational pesticide exposure are consistent with previous work.

Authors+Show Affiliations

Viertel Centre for Research, Queensland Cancer Fund, Brisbane, Queensland, Australia. lfritschi@qldcancer.com.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16177143

Citation

Fritschi, L, et al. "Occupational Exposure to Pesticides and Risk of non-Hodgkin's Lymphoma." American Journal of Epidemiology, vol. 162, no. 9, 2005, pp. 849-57.
Fritschi L, Benke G, Hughes AM, et al. Occupational exposure to pesticides and risk of non-Hodgkin's lymphoma. Am J Epidemiol. 2005;162(9):849-57.
Fritschi, L., Benke, G., Hughes, A. M., Kricker, A., Turner, J., Vajdic, C. M., ... Armstrong, B. K. (2005). Occupational exposure to pesticides and risk of non-Hodgkin's lymphoma. American Journal of Epidemiology, 162(9), pp. 849-57.
Fritschi L, et al. Occupational Exposure to Pesticides and Risk of non-Hodgkin's Lymphoma. Am J Epidemiol. 2005 Nov 1;162(9):849-57. PubMed PMID: 16177143.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Occupational exposure to pesticides and risk of non-Hodgkin's lymphoma. AU - Fritschi,L, AU - Benke,G, AU - Hughes,A M, AU - Kricker,A, AU - Turner,J, AU - Vajdic,C M, AU - Grulich,A, AU - Milliken,S, AU - Kaldor,J, AU - Armstrong,B K, Y1 - 2005/09/21/ PY - 2005/9/24/pubmed PY - 2005/12/13/medline PY - 2005/9/24/entrez SP - 849 EP - 57 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 162 IS - 9 N2 - Pesticide exposure may be a risk factor for non-Hodgkin's lymphoma, but it is not certain which types of pesticides are involved. A population-based case-control study was undertaken in 2000-2001 using detailed methods of assessing occupational pesticide exposure. Cases with incident non-Hodgkin's lymphoma in two Australian states (n = 694) and controls (n = 694) were chosen from Australian electoral rolls. Logistic regression was used to estimate the risks of non-Hodgkin's lymphoma associated with exposure to subgroups of pesticides after adjustment for age, sex, ethnic origin, and residence. Approximately 10% of cases and controls had incurred pesticide exposure. Substantial exposure to any pesticide was associated with a trebling of the risk of non-Hodgkin's lymphoma (odds ratio = 3.09, 95% confidence interval: 1.42, 6.70). Subjects with substantial exposure to organochlorines, organophosphates, and "other pesticides" (all other pesticides excluding herbicides) and herbicides other than phenoxy herbicides had similarly increased risks, although the increase was statistically significant only for "other pesticides." None of the exposure metrics (probability, level, frequency, duration, or years of exposure) were associated with non-Hodgkin's lymphoma. Analyses of the major World Health Organization subtypes of non-Hodgkin's lymphoma suggested a stronger effect for follicular lymphoma. These increases in risk of non-Hodgkin's lymphoma with substantial occupational pesticide exposure are consistent with previous work. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/16177143/Occupational_exposure_to_pesticides_and_risk_of_non_Hodgkin's_lymphoma_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwi292 DB - PRIME DP - Unbound Medicine ER -