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Taurine prevents collagen abnormalities in high fructose-fed rats.
Indian J Med Res. 2005 Aug; 122(2):171-7.IJ

Abstract

BACKGROUND & OBJECTIVE

Accumulation of collagen and changes in its physiochemical properties contribute to the development of secondary complications of diabetes. We undertook this study to see the effects of taurine on the content and characteristics of collagen from tail tendon of rats fed with high fructose diet.

METHODS

The rats were divided into four groups of six each: control group (CON), taurine-supplemented control group (CON+TAU), taurine supplemented (FRU+TAU) and not supplemented fructose-fed group (FRU). The physico-chemical properties of collagen isolated from the tail tendon were studied.

RESULTS

Fructose administration caused accumulation of collagen in tail tendon. Enhanced glycation and advanced glycation end products (AGE)-linked fluorescence together with alterations in aldehyde content, solubility pattern, susceptibility to denaturing agents and shrinkage temperature were observed in fructose-fed rats. Elevated b component of type I collagen was evidenced from the SDS gel pattern of collagen from the fructose-fed rats. Simultaneous administration of taurine alleviated these changes.

INTERPRETATION & CONCLUSION

Taurine administration to fructose-rats had a positive influence on both quantitative and qualitative properties of collagen. The results of the present study suggested a role for the action of taurine in delaying diabetic complications and the possible use of taurine as an adjuvant therapeutic measure in the management of diabetes and its complications.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar 608-002, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16177476

Citation

Nandhini, A T Anitha, et al. "Taurine Prevents Collagen Abnormalities in High Fructose-fed Rats." The Indian Journal of Medical Research, vol. 122, no. 2, 2005, pp. 171-7.
Nandhini AT, Thirunavukkarasu V, Anuradha CV. Taurine prevents collagen abnormalities in high fructose-fed rats. Indian J Med Res. 2005;122(2):171-7.
Nandhini, A. T., Thirunavukkarasu, V., & Anuradha, C. V. (2005). Taurine prevents collagen abnormalities in high fructose-fed rats. The Indian Journal of Medical Research, 122(2), 171-7.
Nandhini AT, Thirunavukkarasu V, Anuradha CV. Taurine Prevents Collagen Abnormalities in High Fructose-fed Rats. Indian J Med Res. 2005;122(2):171-7. PubMed PMID: 16177476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Taurine prevents collagen abnormalities in high fructose-fed rats. AU - Nandhini,A T Anitha, AU - Thirunavukkarasu,V, AU - Anuradha,C V, PY - 2005/9/24/pubmed PY - 2005/12/24/medline PY - 2005/9/24/entrez SP - 171 EP - 7 JF - The Indian journal of medical research JO - Indian J Med Res VL - 122 IS - 2 N2 - BACKGROUND & OBJECTIVE: Accumulation of collagen and changes in its physiochemical properties contribute to the development of secondary complications of diabetes. We undertook this study to see the effects of taurine on the content and characteristics of collagen from tail tendon of rats fed with high fructose diet. METHODS: The rats were divided into four groups of six each: control group (CON), taurine-supplemented control group (CON+TAU), taurine supplemented (FRU+TAU) and not supplemented fructose-fed group (FRU). The physico-chemical properties of collagen isolated from the tail tendon were studied. RESULTS: Fructose administration caused accumulation of collagen in tail tendon. Enhanced glycation and advanced glycation end products (AGE)-linked fluorescence together with alterations in aldehyde content, solubility pattern, susceptibility to denaturing agents and shrinkage temperature were observed in fructose-fed rats. Elevated b component of type I collagen was evidenced from the SDS gel pattern of collagen from the fructose-fed rats. Simultaneous administration of taurine alleviated these changes. INTERPRETATION & CONCLUSION: Taurine administration to fructose-rats had a positive influence on both quantitative and qualitative properties of collagen. The results of the present study suggested a role for the action of taurine in delaying diabetic complications and the possible use of taurine as an adjuvant therapeutic measure in the management of diabetes and its complications. SN - 0971-5916 UR - https://www.unboundmedicine.com/medline/citation/16177476/Taurine_prevents_collagen_abnormalities_in_high_fructose_fed_rats_ DB - PRIME DP - Unbound Medicine ER -