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The kallikrein-kinin system: current and future pharmacological targets.
J Pharmacol Sci. 2005 Sep; 99(1):6-38.JP

Abstract

The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). This complex system includes the precursors of kinins known as kininogens and mainly tissue and plasma kallikreins. The pharmacologically active kinins, which are often considered as either proinflammatory or cardioprotective, are implicated in many physiological and pathological processes. The interest of the various components of this multi-protein system is explained in part by the multiplicity of its pharmacological activities, mediated not only by kinins and their receptors, but also by their precursors and their activators and the metallopeptidases and the antiproteases that limit their activities. The regulation of this system by serpins and the wide distribution of the different constituents add to the complexity of this system, as well as its multiple relationships with other important metabolic pathways such as the renin-angiotensin, coagulation, or complement pathways. The purpose of this review is to summarize the main properties of this kallikrein-kinin system and to address the multiple pharmacological interventions that modulate the functions of this system, restraining its proinflammatory effects or potentiating its cardiovascular properties.

Authors+Show Affiliations

Faculty of Pharmacy, University of Montreal, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

16177542

Citation

Moreau, Marie Eve, et al. "The Kallikrein-kinin System: Current and Future Pharmacological Targets." Journal of Pharmacological Sciences, vol. 99, no. 1, 2005, pp. 6-38.
Moreau ME, Garbacki N, Molinaro G, et al. The kallikrein-kinin system: current and future pharmacological targets. J Pharmacol Sci. 2005;99(1):6-38.
Moreau, M. E., Garbacki, N., Molinaro, G., Brown, N. J., Marceau, F., & Adam, A. (2005). The kallikrein-kinin system: current and future pharmacological targets. Journal of Pharmacological Sciences, 99(1), 6-38.
Moreau ME, et al. The Kallikrein-kinin System: Current and Future Pharmacological Targets. J Pharmacol Sci. 2005;99(1):6-38. PubMed PMID: 16177542.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The kallikrein-kinin system: current and future pharmacological targets. AU - Moreau,Marie Eve, AU - Garbacki,Nancy, AU - Molinaro,Giuseppe, AU - Brown,Nancy J, AU - Marceau,François, AU - Adam,Albert, PY - 2005/9/24/pubmed PY - 2006/5/4/medline PY - 2005/9/24/entrez SP - 6 EP - 38 JF - Journal of pharmacological sciences JO - J. Pharmacol. Sci. VL - 99 IS - 1 N2 - The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). This complex system includes the precursors of kinins known as kininogens and mainly tissue and plasma kallikreins. The pharmacologically active kinins, which are often considered as either proinflammatory or cardioprotective, are implicated in many physiological and pathological processes. The interest of the various components of this multi-protein system is explained in part by the multiplicity of its pharmacological activities, mediated not only by kinins and their receptors, but also by their precursors and their activators and the metallopeptidases and the antiproteases that limit their activities. The regulation of this system by serpins and the wide distribution of the different constituents add to the complexity of this system, as well as its multiple relationships with other important metabolic pathways such as the renin-angiotensin, coagulation, or complement pathways. The purpose of this review is to summarize the main properties of this kallikrein-kinin system and to address the multiple pharmacological interventions that modulate the functions of this system, restraining its proinflammatory effects or potentiating its cardiovascular properties. SN - 1347-8613 UR - https://www.unboundmedicine.com/medline/citation/16177542/The_kallikrein_kinin_system:_current_and_future_pharmacological_targets_ L2 - https://linkinghub.elsevier.com/retrieve/pii/JST.JSTAGE/jphs/SRJ05001X DB - PRIME DP - Unbound Medicine ER -