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Readily tunable and bifunctional L-prolinamide derivatives: design and application in the direct enantioselective Aldol reactions.
Org Lett. 2005 Sep 29; 7(20):4543-5.OL

Abstract

[reaction: see text] Readily tunable and bifunctional L-prolinamides as novel organocatalysts have been developed, and their catalytic activities were evaluated in the direct asymmetric Aldol reactions of various aromatic aldehydes and cyclohexanone. High isolated yields (up to 94%), enantioselectivities (up to 99% ee), and anti-diastereoselectivities (up to 99:1) were obtained under the optimal conditions.

Authors+Show Affiliations

Chen JR
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China.
Lu HH
No affiliation info available
Li XY
No affiliation info available
Cheng L
No affiliation info available
Wan J
No affiliation info available
Xiao WJ
No affiliation info available

MeSH

AldehydesCatalysisCyclohexanonesDrug DesignMolecular StructureProlineStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16178579

Citation

Chen, Jia-Rong, et al. "Readily Tunable and Bifunctional L-prolinamide Derivatives: Design and Application in the Direct Enantioselective Aldol Reactions." Organic Letters, vol. 7, no. 20, 2005, pp. 4543-5.
Chen JR, Lu HH, Li XY, et al. Readily tunable and bifunctional L-prolinamide derivatives: design and application in the direct enantioselective Aldol reactions. Org Lett. 2005;7(20):4543-5.
Chen, J. R., Lu, H. H., Li, X. Y., Cheng, L., Wan, J., & Xiao, W. J. (2005). Readily tunable and bifunctional L-prolinamide derivatives: design and application in the direct enantioselective Aldol reactions. Organic Letters, 7(20), 4543-5.
Chen JR, et al. Readily Tunable and Bifunctional L-prolinamide Derivatives: Design and Application in the Direct Enantioselective Aldol Reactions. Org Lett. 2005 Sep 29;7(20):4543-5. PubMed PMID: 16178579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Readily tunable and bifunctional L-prolinamide derivatives: design and application in the direct enantioselective Aldol reactions. AU - Chen,Jia-Rong, AU - Lu,Hai-Hua, AU - Li,Xin-Yong, AU - Cheng,Lin, AU - Wan,Jian, AU - Xiao,Wen-Jing, PY - 2005/9/24/pubmed PY - 2006/8/5/medline PY - 2005/9/24/entrez SP - 4543 EP - 5 JF - Organic letters JO - Org Lett VL - 7 IS - 20 N2 - [reaction: see text] Readily tunable and bifunctional L-prolinamides as novel organocatalysts have been developed, and their catalytic activities were evaluated in the direct asymmetric Aldol reactions of various aromatic aldehydes and cyclohexanone. High isolated yields (up to 94%), enantioselectivities (up to 99% ee), and anti-diastereoselectivities (up to 99:1) were obtained under the optimal conditions. SN - 1523-7060 UR - https://www.unboundmedicine.com/medline/citation/16178579/Readily_tunable_and_bifunctional_L_prolinamide_derivatives:_design_and_application_in_the_direct_enantioselective_Aldol_reactions_ DB - PRIME DP - Unbound Medicine ER -