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Prevalence and severity of gait disorders in Alzheimer's and non-Alzheimer's dementias.
J Am Geriatr Soc. 2005 Oct; 53(10):1681-7.JA

Abstract

OBJECTIVES

To compare the prevalence, severity, and type of gait and balance disorders in Alzheimer's disease (AD), vascular dementia (VaD), Parkinson's disease with dementia (PDD), dementia with Lewy bodies (DLB), Parkinson's disease without dementia (PD), and age-matched controls.

DESIGN

Cross-sectional.

SETTING

Secondary care clinics in geriatric psychiatry, neurology, and geriatrics.

PARTICIPANTS

Two hundred forty-five participants aged 65 and older (AD, n=40; VaD, n=39; PDD, n=46; DLB, n=32; PD, n=46; and controls, n=42).

MEASUREMENTS

Prevalence and severity of gait and balance disorders were assessed using the Tinetti gait and balance scale. The types of gait disorders in each diagnostic group were classified using the Nutt et al. classification.

RESULTS

Gait and balance disorders were more common with PDD (93%), VaD (79%), and DLB (75%) than with PD (43%) and AD (25%) and in controls (7%). The risk of gait and balance disorder was higher in the non-Alzheimer's dementia groups (VaD, PDD, and DLB) than in the AD group (odds ratio=15 (95% confidence interval=6-37). If a gait disorder was present in mild dementia (Cambridge Examination for Mental Disorders of the Elderly cognitive subsection score >65), this was diagnostic of non-Alzheimer's dementia, with sensitivity of 78% and specificity of 100%. Non-Alzheimer's dementia groups had worse Tinetti gait and balance scores than the AD group (all P<.001). The types of gait disorders discriminated between non-Alzheimer's dementias.

CONCLUSION

The findings support the idea that gait and balance assessment may augment the diagnostic evaluation of dementia.

Authors+Show Affiliations

Institute for Aging and Health, University of Newcastle upon Tyne, United Kingdom. louise.allan@ncl.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16181166

Citation

Allan, Louise M., et al. "Prevalence and Severity of Gait Disorders in Alzheimer's and non-Alzheimer's Dementias." Journal of the American Geriatrics Society, vol. 53, no. 10, 2005, pp. 1681-7.
Allan LM, Ballard CG, Burn DJ, et al. Prevalence and severity of gait disorders in Alzheimer's and non-Alzheimer's dementias. J Am Geriatr Soc. 2005;53(10):1681-7.
Allan, L. M., Ballard, C. G., Burn, D. J., & Kenny, R. A. (2005). Prevalence and severity of gait disorders in Alzheimer's and non-Alzheimer's dementias. Journal of the American Geriatrics Society, 53(10), 1681-7.
Allan LM, et al. Prevalence and Severity of Gait Disorders in Alzheimer's and non-Alzheimer's Dementias. J Am Geriatr Soc. 2005;53(10):1681-7. PubMed PMID: 16181166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and severity of gait disorders in Alzheimer's and non-Alzheimer's dementias. AU - Allan,Louise M, AU - Ballard,Clive G, AU - Burn,David J, AU - Kenny,Rose Anne, PY - 2005/9/27/pubmed PY - 2006/1/13/medline PY - 2005/9/27/entrez SP - 1681 EP - 7 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 53 IS - 10 N2 - OBJECTIVES: To compare the prevalence, severity, and type of gait and balance disorders in Alzheimer's disease (AD), vascular dementia (VaD), Parkinson's disease with dementia (PDD), dementia with Lewy bodies (DLB), Parkinson's disease without dementia (PD), and age-matched controls. DESIGN: Cross-sectional. SETTING: Secondary care clinics in geriatric psychiatry, neurology, and geriatrics. PARTICIPANTS: Two hundred forty-five participants aged 65 and older (AD, n=40; VaD, n=39; PDD, n=46; DLB, n=32; PD, n=46; and controls, n=42). MEASUREMENTS: Prevalence and severity of gait and balance disorders were assessed using the Tinetti gait and balance scale. The types of gait disorders in each diagnostic group were classified using the Nutt et al. classification. RESULTS: Gait and balance disorders were more common with PDD (93%), VaD (79%), and DLB (75%) than with PD (43%) and AD (25%) and in controls (7%). The risk of gait and balance disorder was higher in the non-Alzheimer's dementia groups (VaD, PDD, and DLB) than in the AD group (odds ratio=15 (95% confidence interval=6-37). If a gait disorder was present in mild dementia (Cambridge Examination for Mental Disorders of the Elderly cognitive subsection score >65), this was diagnostic of non-Alzheimer's dementia, with sensitivity of 78% and specificity of 100%. Non-Alzheimer's dementia groups had worse Tinetti gait and balance scores than the AD group (all P<.001). The types of gait disorders discriminated between non-Alzheimer's dementias. CONCLUSION: The findings support the idea that gait and balance assessment may augment the diagnostic evaluation of dementia. SN - 0002-8614 UR - https://www.unboundmedicine.com/medline/citation/16181166/Prevalence_and_severity_of_gait_disorders_in_Alzheimer's_and_non_Alzheimer's_dementias_ L2 - https://doi.org/10.1111/j.1532-5415.2005.53552.x DB - PRIME DP - Unbound Medicine ER -